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• W3204472017 abstract "Sorghum is one of the most important food and feed cereal crops and has been gaining industrial importance in recent years for its biofuel, nutraceutical and antioxidant values. A genetic profile variation study was undertaken for the accumulation of phytochemicals in 61 diverse sorghum accessions differing in their growth habitat and grain color through non-targeted Gas Chromatography-Mass Spectrometry (GC-MS/MS) analysis. Mass Spectrometry-Data Independent AnaLysis (MS-DIAL) and MetaboAnalyst identified 221 metabolites belonging to 27 different phytochemicals. Tropical and temperate sorghums were distinct in their metabolic profiles with minimum overlaps, and 51 different metabolites were crucial in differentiating the two groups. Temperate sorghums had the ability to accumulate more of phenolic acids, phytosterols, flavonoids, carotenoids, and tropical sorghums for stress-related amino acids, sugars and fatty acids. Grain-color-based Partial Least Square-Discriminant Analysis (PLS-DA) analysis identified 94 Variable Importance in Projections (VIP) metabolites containing majority of flavonoids, phenylpropanoids and phytosterols. This study identified two sorghum lines (IS 7748 and IS 14861) with rich amounts of antioxidants (catechins and epicatechins) belonging to the group of condensed tannins that otherwise do not accumulate commonly in sorghum. Out of 13 metabolic pathways identified, flavonoid biosynthesis showed the highest expression. This study provided new opportunities for developing biofortified sorghum with enhanced nutraceutical and therapeutics through molecular breeding and metabolic engineering." @default.
• W3204472017 created "2021-10-11" @default.
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• W3204472017 date "2021-09-23" @default.
• W3204472017 modified "2023-10-02" @default.
• W3204472017 title "Large-Scale Non-Targeted Metabolomics Reveals Antioxidant, Nutraceutical and Therapeutic Potentials of Sorghum" @default.
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• W3204472017 doi "https://doi.org/10.3390/antiox10101511" @default.
• W3204472017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8532915" @default.
• W3204472017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34679645" @default.
• W3204472017 hasPublicationYear "2021" @default.
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