FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204478051> ?p ?o ?g. }

• W3204478051 endingPage "2009" @default.
• W3204478051 startingPage "2001" @default.
• W3204478051 abstract "Abstract Background False positivity may hinder the utility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serological tests in sub-Saharan Africa. Methods From 312 Malian samples collected before 2020, we measured antibodies to the commonly tested SARS-CoV-2 antigens and 4 other betacoronaviruses by enzyme-linked immunosorbent assay (ELISA). In a subset of samples, we assessed antibodies to a panel of Plasmodium falciparum antigens by suspension bead array and functional antiviral activity by SARS-CoV-2 pseudovirus neutralization assay. We then evaluated the performance of an ELISA using SARS-CoV-2 spike protein and receptor-binding domain developed in the United States using Malian positive and negative control samples. To optimize test performance, we compared single- and 2-antigen approaches using existing assay cutoffs and population-specific cutoffs. Results Background reactivity to SARS-CoV-2 antigens was common in prepandemic Malian samples. The SARS-CoV-2 reactivity varied between communities, increased with age, and correlated negligibly/weakly with other betacoronavirus and P falciparum antibodies. No prepandemic samples demonstrated functional activity. Regardless of the cutoffs applied, test specificity improved using a 2-antigen approach. Test performance was optimal using a 2-antigen assay with population-specific cutoffs (sensitivity, 73.9% [95% confidence interval {CI}, 51.6–89.8]; specificity, 99.4% [95% CI, 97.7–99.9]). Conclusions We have addressed the problem of SARS-CoV-2 seroassay performance in Africa by using a 2-antigen assay with cutoffs defined by performance in the target population." @default.
• W3204478051 created "2021-10-11" @default.
• W3204478051 creator A5002252186 @default.
• W3204478051 creator A5006684163 @default.
• W3204478051 creator A5016446812 @default.
• W3204478051 creator A5016702194 @default.
• W3204478051 creator A5028327649 @default.
• W3204478051 creator A5030635221 @default.
• W3204478051 creator A5034122767 @default.
• W3204478051 creator A5035805252 @default.
• W3204478051 creator A5041698229 @default.
• W3204478051 creator A5049967604 @default.
• W3204478051 creator A5050112210 @default.
• W3204478051 creator A5054063398 @default.
• W3204478051 creator A5061862122 @default.
• W3204478051 creator A5062591099 @default.
• W3204478051 creator A5070319506 @default.
• W3204478051 creator A5077580996 @default.
• W3204478051 creator A5091242339 @default.
• W3204478051 date "2021-10-06" @default.
• W3204478051 modified "2023-10-17" @default.
• W3204478051 title "Severe Acute Respiratory Syndrome Coronavirus 2 Seroassay Performance and Optimization in a Population With High Background Reactivity in Mali" @default.
• W3204478051 cites W1531237901 @default.
• W3204478051 cites W2045999568 @default.
• W3204478051 cites W2152575748 @default.
• W3204478051 cites W2594912959 @default.
• W3204478051 cites W2911817059 @default.
• W3204478051 cites W2967532977 @default.
• W3204478051 cites W3024178701 @default.
• W3204478051 cites W3026406444 @default.
• W3204478051 cites W3032255042 @default.
• W3204478051 cites W3033029188 @default.
• W3204478051 cites W3034680516 @default.
• W3204478051 cites W3049192460 @default.
• W3204478051 cites W3087128437 @default.
• W3204478051 cites W3089823558 @default.
• W3204478051 cites W3094898198 @default.
• W3204478051 cites W3099989333 @default.
• W3204478051 cites W3107323637 @default.
• W3204478051 cites W3110578956 @default.
• W3204478051 cites W3112356527 @default.
• W3204478051 cites W3120636457 @default.
• W3204478051 cites W3133467376 @default.
• W3204478051 cites W3137163680 @default.
• W3204478051 cites W3156230686 @default.
• W3204478051 cites W3173594962 @default.
• W3204478051 cites W3173785513 @default.
• W3204478051 cites W3177069673 @default.
• W3204478051 cites W4248183909 @default.
• W3204478051 doi "https://doi.org/10.1093/infdis/jiab498" @default.
• W3204478051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8522418" @default.
• W3204478051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34612499" @default.
• W3204478051 hasPublicationYear "2021" @default.
• W3204478051 type Work @default.
• W3204478051 sameAs 3204478051 @default.
• W3204478051 citedByCount "29" @default.
• W3204478051 countsByYear W32044780512021 @default.
• W3204478051 countsByYear W32044780512022 @default.
• W3204478051 countsByYear W32044780512023 @default.
• W3204478051 crossrefType "journal-article" @default.
• W3204478051 hasAuthorship W3204478051A5002252186 @default.
• W3204478051 hasAuthorship W3204478051A5006684163 @default.
• W3204478051 hasAuthorship W3204478051A5016446812 @default.
• W3204478051 hasAuthorship W3204478051A5016702194 @default.
• W3204478051 hasAuthorship W3204478051A5028327649 @default.
• W3204478051 hasAuthorship W3204478051A5030635221 @default.
• W3204478051 hasAuthorship W3204478051A5034122767 @default.
• W3204478051 hasAuthorship W3204478051A5035805252 @default.
• W3204478051 hasAuthorship W3204478051A5041698229 @default.
• W3204478051 hasAuthorship W3204478051A5049967604 @default.
• W3204478051 hasAuthorship W3204478051A5050112210 @default.
• W3204478051 hasAuthorship W3204478051A5054063398 @default.
• W3204478051 hasAuthorship W3204478051A5061862122 @default.
• W3204478051 hasAuthorship W3204478051A5062591099 @default.
• W3204478051 hasAuthorship W3204478051A5070319506 @default.
• W3204478051 hasAuthorship W3204478051A5077580996 @default.
• W3204478051 hasAuthorship W3204478051A5091242339 @default.
• W3204478051 hasBestOaLocation W32044780512 @default.
• W3204478051 hasConcept C126322002 @default.
• W3204478051 hasConcept C147483822 @default.
• W3204478051 hasConcept C159047783 @default.
• W3204478051 hasConcept C159654299 @default.
• W3204478051 hasConcept C203014093 @default.
• W3204478051 hasConcept C2777648638 @default.
• W3204478051 hasConcept C2778137277 @default.
• W3204478051 hasConcept C2779134260 @default.
• W3204478051 hasConcept C2908647359 @default.
• W3204478051 hasConcept C3008058167 @default.
• W3204478051 hasConcept C44249647 @default.
• W3204478051 hasConcept C45189115 @default.
• W3204478051 hasConcept C524204448 @default.
• W3204478051 hasConcept C71924100 @default.
• W3204478051 hasConcept C86803240 @default.
• W3204478051 hasConcept C99454951 @default.
• W3204478051 hasConceptScore W3204478051C126322002 @default.
• W3204478051 hasConceptScore W3204478051C147483822 @default.
• W3204478051 hasConceptScore W3204478051C159047783 @default.
• W3204478051 hasConceptScore W3204478051C159654299 @default.

• next