Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204497499> ?p ?o ?g. }
- W3204497499 endingPage "e08106" @default.
- W3204497499 startingPage "e08106" @default.
- W3204497499 abstract "High salt diet (HSD) has been implicated in the etiopathogenesis of immune derangement, cardiovascular disorders and, metabolic syndromes. This study investigated the protective effect of ethanol extract of Phyllanthus amarus (EEPA) against high salt diet (HSD) induced biochemical and metabolic derangement in male Wistar rats. The rats were divided into 5 groups of 6 animals each as follows; control group fed with normal rat chow, negative control group, fed HSD only, animals on HSD treated orally with 75 mg/kg, 100 mg/kg, and, 150 mg/kg EEPA once daily. At the end of 8 weeks treatment, lipid profile (TG, TC, LDL, and VLDL), oxidative stress (catalase, reduced glutathione, and malondialdehyde), inflammatory (TNF-a, interleukins 2, 6, and 8), cardiac (lactate dehydrogenase, creatine kinase) and kidney function markers (urea, uric acid, creatinine) were assessed. Serum TG, TC, LDL, and VLDL content were significantly (p < 0.05) elevated in HSD-only fed rats, while HDL was significantly elevated in a concentration-dependent manner in EEPA treated animals. The extract produced a significant (p < 0.05) and dose-dependent increase in the antioxidant enzymes activities and a significant reduction in the malondialdehyde level. A significant (p < 0.05) dose-dependent reduction in serum TNF-alpha, IL-2, 6, and 8 of EEPA treated rats compared with HSD-fed rats was observed. More so, reduction in serum LDH, creatine kinase, creatinine, urea, and uric acid activity of extract-treated animals were noted. EEPA attenuated high salt diet-induced oxidative stress, inflammation, and dyslipidemia in rats." @default.
- W3204497499 created "2021-10-11" @default.
- W3204497499 creator A5009837605 @default.
- W3204497499 creator A5026066745 @default.
- W3204497499 creator A5029054688 @default.
- W3204497499 creator A5055857031 @default.
- W3204497499 creator A5066267821 @default.
- W3204497499 creator A5070642782 @default.
- W3204497499 date "2021-10-01" @default.
- W3204497499 modified "2023-09-24" @default.
- W3204497499 title "Phyllanthus amarus attenuated derangement in renal-cardiac function, redox status, lipid profile and reduced TNF-α, interleukins-2, 6 and 8 in high salt diet fed rats" @default.
- W3204497499 cites W194822541 @default.
- W3204497499 cites W1983310681 @default.
- W3204497499 cites W2005930301 @default.
- W3204497499 cites W2015414831 @default.
- W3204497499 cites W2021280090 @default.
- W3204497499 cites W2023662170 @default.
- W3204497499 cites W2034357128 @default.
- W3204497499 cites W2036541538 @default.
- W3204497499 cites W2045585480 @default.
- W3204497499 cites W2047705840 @default.
- W3204497499 cites W2048629418 @default.
- W3204497499 cites W2049627411 @default.
- W3204497499 cites W2052698249 @default.
- W3204497499 cites W2058451140 @default.
- W3204497499 cites W2059684897 @default.
- W3204497499 cites W2063576996 @default.
- W3204497499 cites W2063700634 @default.
- W3204497499 cites W2076120749 @default.
- W3204497499 cites W2098559633 @default.
- W3204497499 cites W2116404316 @default.
- W3204497499 cites W2122560536 @default.
- W3204497499 cites W2139654366 @default.
- W3204497499 cites W2149366307 @default.
- W3204497499 cites W2149681111 @default.
- W3204497499 cites W2154055479 @default.
- W3204497499 cites W2154461351 @default.
- W3204497499 cites W2228783918 @default.
- W3204497499 cites W2280892707 @default.
- W3204497499 cites W2315595098 @default.
- W3204497499 cites W2330769412 @default.
- W3204497499 cites W2331258196 @default.
- W3204497499 cites W2508300379 @default.
- W3204497499 cites W2520168155 @default.
- W3204497499 cites W2595930401 @default.
- W3204497499 cites W2612544850 @default.
- W3204497499 cites W2670991862 @default.
- W3204497499 cites W2734432184 @default.
- W3204497499 cites W2758186890 @default.
- W3204497499 cites W2772210971 @default.
- W3204497499 cites W2791759492 @default.
- W3204497499 cites W2805729978 @default.
- W3204497499 cites W2932274093 @default.
- W3204497499 cites W2944467213 @default.
- W3204497499 cites W3080602626 @default.
- W3204497499 cites W3154426821 @default.
- W3204497499 cites W3157942784 @default.
- W3204497499 cites W69255949 @default.
- W3204497499 doi "https://doi.org/10.1016/j.heliyon.2021.e08106" @default.
- W3204497499 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8502905" @default.
- W3204497499 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34660924" @default.
- W3204497499 hasPublicationYear "2021" @default.
- W3204497499 type Work @default.
- W3204497499 sameAs 3204497499 @default.
- W3204497499 citedByCount "1" @default.
- W3204497499 countsByYear W32044974992022 @default.
- W3204497499 crossrefType "journal-article" @default.
- W3204497499 hasAuthorship W3204497499A5009837605 @default.
- W3204497499 hasAuthorship W3204497499A5026066745 @default.
- W3204497499 hasAuthorship W3204497499A5029054688 @default.
- W3204497499 hasAuthorship W3204497499A5055857031 @default.
- W3204497499 hasAuthorship W3204497499A5066267821 @default.
- W3204497499 hasAuthorship W3204497499A5070642782 @default.
- W3204497499 hasBestOaLocation W32044974991 @default.
- W3204497499 hasConcept C126322002 @default.
- W3204497499 hasConcept C134018914 @default.
- W3204497499 hasConcept C159641895 @default.
- W3204497499 hasConcept C181199279 @default.
- W3204497499 hasConcept C185592680 @default.
- W3204497499 hasConcept C2776151105 @default.
- W3204497499 hasConcept C2777318727 @default.
- W3204497499 hasConcept C2778163477 @default.
- W3204497499 hasConcept C2778270857 @default.
- W3204497499 hasConcept C2778401633 @default.
- W3204497499 hasConcept C2779881121 @default.
- W3204497499 hasConcept C2780306776 @default.
- W3204497499 hasConcept C36880943 @default.
- W3204497499 hasConcept C55493867 @default.
- W3204497499 hasConcept C71924100 @default.
- W3204497499 hasConceptScore W3204497499C126322002 @default.
- W3204497499 hasConceptScore W3204497499C134018914 @default.
- W3204497499 hasConceptScore W3204497499C159641895 @default.
- W3204497499 hasConceptScore W3204497499C181199279 @default.
- W3204497499 hasConceptScore W3204497499C185592680 @default.
- W3204497499 hasConceptScore W3204497499C2776151105 @default.
- W3204497499 hasConceptScore W3204497499C2777318727 @default.
- W3204497499 hasConceptScore W3204497499C2778163477 @default.
- W3204497499 hasConceptScore W3204497499C2778270857 @default.