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• W3204499867 endingPage "H1041" @default.
• W3204499867 startingPage "H1030" @default.
• W3204499867 abstract "The no reflow phenomenon, where the coronary artery is patent after treatment of acute myocardial infarction (AMI) but tissue perfusion is not restored, is associated with worse outcome. The mechanism of no reflow is unknown. We hypothesized that pericytes contraction, in an attempt to maintain a constant capillary hydrostatic pressure during reduced coronary perfusion pressure, causes capillary constriction leading to no reflow and that this effect is mediated through the orphan receptor, GPR39, present in pericytes. We created AMI (coronary occlusion followed by reperfusion) in GPR39 knock out mice and littermate controls. In a separate set of experiments, we treated wild-type mice undergoing coronary occlusion with vehicle or VC43, a specific inhibitor of GPR39, before reperfusion. We found that no reflow zones were significantly smaller in the GPR39 knockouts compared with controls. Both no reflow and infarct size were also markedly smaller in animals treated with VC43 compared with vehicle. Immunohistochemistry revealed greater capillary density and larger capillary diameter at pericyte locations in the GPR39-knockout and VC43-treated mice compared with controls. We conclude that GPR39-mediated pericyte contraction during reduced coronary perfusion pressure causes capillary constriction resulting in no reflow during AMI and that smaller no reflow zones in GPR39-knockout and VC43-treated animals are associated with smaller infarct sizes. These results elucidate the mechanism of no reflow in AMI, as well as providing a therapeutic pathway for the condition.NEW & NOTEWORTHY The mechanism of no reflow phenomenon, where the coronary artery is patent after treatment of acute myocardial infarction but tissue perfusion is not restored, is unknown. This condition is associated with worse outcome. Here, we show that GPR39-mediated pericyte contraction during reduced coronary perfusion pressure causes capillary constriction resulting in no reflow. Smaller no-reflow zones in GPR39-knockout animals and those treated with a GPR39 inhibitor are associated with smaller infarct size. These results could have important therapeutic implications." @default.
• W3204499867 created "2021-10-11" @default.
• W3204499867 creator A5031938939 @default.
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• W3204499867 creator A5056499233 @default.
• W3204499867 creator A5063537486 @default.
• W3204499867 date "2021-12-01" @default.
• W3204499867 modified "2023-10-18" @default.
• W3204499867 title "Mechanism and potential treatment of the “no reflow” phenomenon after acute myocardial infarction: role of pericytes and GPR39" @default.
• W3204499867 cites W143757162 @default.
• W3204499867 cites W1968310513 @default.
• W3204499867 cites W1970124330 @default.
• W3204499867 cites W1976319817 @default.
• W3204499867 cites W1983567586 @default.
• W3204499867 cites W1990624455 @default.
• W3204499867 cites W1991117742 @default.
• W3204499867 cites W2001552996 @default.
• W3204499867 cites W2010055509 @default.
• W3204499867 cites W2013800949 @default.
• W3204499867 cites W2016998148 @default.
• W3204499867 cites W2018303185 @default.
• W3204499867 cites W2021253052 @default.
• W3204499867 cites W2023890635 @default.
• W3204499867 cites W2033269131 @default.
• W3204499867 cites W2036024297 @default.
• W3204499867 cites W2036636563 @default.
• W3204499867 cites W2048158572 @default.
• W3204499867 cites W2048902590 @default.
• W3204499867 cites W2051030085 @default.
• W3204499867 cites W2051547321 @default.
• W3204499867 cites W2051732586 @default.
• W3204499867 cites W2053259657 @default.
• W3204499867 cites W2054418390 @default.
• W3204499867 cites W2064778528 @default.
• W3204499867 cites W2067191075 @default.
• W3204499867 cites W2068734467 @default.
• W3204499867 cites W2069929255 @default.
• W3204499867 cites W2070713204 @default.
• W3204499867 cites W2071819457 @default.
• W3204499867 cites W2073165844 @default.
• W3204499867 cites W2074131116 @default.
• W3204499867 cites W2074912415 @default.
• W3204499867 cites W2075173075 @default.
• W3204499867 cites W2075499032 @default.
• W3204499867 cites W2079542361 @default.
• W3204499867 cites W2082339204 @default.
• W3204499867 cites W2083585508 @default.
• W3204499867 cites W2085500137 @default.
• W3204499867 cites W2087535057 @default.
• W3204499867 cites W2088087008 @default.
• W3204499867 cites W2090466864 @default.
• W3204499867 cites W2094145779 @default.
• W3204499867 cites W2096751472 @default.
• W3204499867 cites W2099796990 @default.
• W3204499867 cites W2102964484 @default.
• W3204499867 cites W2108082043 @default.
• W3204499867 cites W2113350818 @default.
• W3204499867 cites W2114611409 @default.
• W3204499867 cites W2119396182 @default.
• W3204499867 cites W2121316464 @default.
• W3204499867 cites W2125006453 @default.
• W3204499867 cites W2125048739 @default.
• W3204499867 cites W2128605706 @default.
• W3204499867 cites W2130501478 @default.
• W3204499867 cites W2133190533 @default.
• W3204499867 cites W2136009429 @default.
• W3204499867 cites W2140233303 @default.
• W3204499867 cites W2144176357 @default.
• W3204499867 cites W2148706034 @default.
• W3204499867 cites W2159689462 @default.
• W3204499867 cites W2162795567 @default.
• W3204499867 cites W2164823158 @default.
• W3204499867 cites W2320961849 @default.
• W3204499867 cites W2414233652 @default.
• W3204499867 cites W2516254780 @default.
• W3204499867 cites W2517136081 @default.
• W3204499867 cites W2536398251 @default.
• W3204499867 cites W2727133529 @default.
• W3204499867 cites W2767351904 @default.
• W3204499867 cites W2792281792 @default.
• W3204499867 cites W2888034265 @default.
• W3204499867 cites W2945745934 @default.
• W3204499867 cites W3091832293 @default.
• W3204499867 cites W3207842273 @default.
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• W3204499867 doi "https://doi.org/10.1152/ajpheart.00312.2021" @default.
• W3204499867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34623177" @default.
• W3204499867 hasPublicationYear "2021" @default.
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