Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204522102> ?p ?o ?g. }
- W3204522102 abstract "Tamoxifen (TMX) is used as adjuvant therapy for estrogen receptor-positive (ER+) breast cancer cases due to its affinity and inhibitory effects. However, about 30% of cases show drug resistance, resulting in recurrence and metastasis, the leading causes of death. A literature review can help to elucidate the main cellular processes involved in TMX resistance. A scoping review was performed to find clinical studies investigating the association of expression of molecular markers profiles with long-term outcomes in ER+ patients treated with TMX. In silico analysis was performed to assess the interrelationship among the selected markers, evaluating the joint involvement with the biological processes. Forty-five studies were selected according to the inclusion and exclusion criteria. After clustering and gene ontology analysis, 23 molecular markers were significantly associated, forming three clusters of strong correlation with cell cycle regulation, signal transduction of proliferative stimuli, and hormone response involved in morphogenesis and differentiation of mammary gland. Also, it was found that overexpression of markers in selected clusters is a significant indicator of poor overall survival. The proposed review offered a better understanding of independent data from the literature, revealing an integrative network of markers involved in cellular processes that could modulate the response of TMX. Analysis of these mechanisms and their molecular components could improve the effectiveness of TMX." @default.
- W3204522102 created "2021-10-11" @default.
- W3204522102 creator A5005648318 @default.
- W3204522102 creator A5012992019 @default.
- W3204522102 creator A5013377875 @default.
- W3204522102 creator A5014768293 @default.
- W3204522102 creator A5015889658 @default.
- W3204522102 creator A5025058347 @default.
- W3204522102 creator A5032442154 @default.
- W3204522102 creator A5058578612 @default.
- W3204522102 creator A5064026498 @default.
- W3204522102 date "2021-10-01" @default.
- W3204522102 modified "2023-10-18" @default.
- W3204522102 title "Molecular markers associated with the outcome of tamoxifen treatment in estrogen receptor-positive breast cancer patients: scoping review and in silico analysis" @default.
- W3204522102 cites W1219777200 @default.
- W3204522102 cites W1757407923 @default.
- W3204522102 cites W1778033632 @default.
- W3204522102 cites W1786110777 @default.
- W3204522102 cites W1898471415 @default.
- W3204522102 cites W1955010715 @default.
- W3204522102 cites W1963505593 @default.
- W3204522102 cites W1964251242 @default.
- W3204522102 cites W1967997862 @default.
- W3204522102 cites W1980150890 @default.
- W3204522102 cites W1980357874 @default.
- W3204522102 cites W1980680120 @default.
- W3204522102 cites W1984519260 @default.
- W3204522102 cites W1990542495 @default.
- W3204522102 cites W1992635305 @default.
- W3204522102 cites W1994552886 @default.
- W3204522102 cites W1999691617 @default.
- W3204522102 cites W2000266878 @default.
- W3204522102 cites W2013643357 @default.
- W3204522102 cites W2013956549 @default.
- W3204522102 cites W2016964184 @default.
- W3204522102 cites W2019942595 @default.
- W3204522102 cites W2023906705 @default.
- W3204522102 cites W2035322382 @default.
- W3204522102 cites W2040548599 @default.
- W3204522102 cites W2047932287 @default.
- W3204522102 cites W2053639830 @default.
- W3204522102 cites W2054822521 @default.
- W3204522102 cites W2055861869 @default.
- W3204522102 cites W2060345758 @default.
- W3204522102 cites W2064038767 @default.
- W3204522102 cites W2067330762 @default.
- W3204522102 cites W2074956467 @default.
- W3204522102 cites W2080407374 @default.
- W3204522102 cites W2081562657 @default.
- W3204522102 cites W2082565035 @default.
- W3204522102 cites W2085934079 @default.
- W3204522102 cites W2094437621 @default.
- W3204522102 cites W2102803803 @default.
- W3204522102 cites W2105882193 @default.
- W3204522102 cites W2106787323 @default.
- W3204522102 cites W2109838603 @default.
- W3204522102 cites W2117053852 @default.
- W3204522102 cites W2117357260 @default.
- W3204522102 cites W2117692326 @default.
- W3204522102 cites W2131184855 @default.
- W3204522102 cites W2134148782 @default.
- W3204522102 cites W2134168579 @default.
- W3204522102 cites W2137028370 @default.
- W3204522102 cites W2139461139 @default.
- W3204522102 cites W2141606491 @default.
- W3204522102 cites W2159089268 @default.
- W3204522102 cites W2159640574 @default.
- W3204522102 cites W2160064770 @default.
- W3204522102 cites W2161696602 @default.
- W3204522102 cites W2167100085 @default.
- W3204522102 cites W2172012098 @default.
- W3204522102 cites W2279779120 @default.
- W3204522102 cites W2288742872 @default.
- W3204522102 cites W2309855341 @default.
- W3204522102 cites W2326348097 @default.
- W3204522102 cites W2339728525 @default.
- W3204522102 cites W2400265361 @default.
- W3204522102 cites W2438542125 @default.
- W3204522102 cites W2474700794 @default.
- W3204522102 cites W2517331792 @default.
- W3204522102 cites W2599358225 @default.
- W3204522102 cites W2601621556 @default.
- W3204522102 cites W2606402996 @default.
- W3204522102 cites W2656455856 @default.
- W3204522102 cites W2731529958 @default.
- W3204522102 cites W2741277091 @default.
- W3204522102 cites W2742281710 @default.
- W3204522102 cites W2757468660 @default.
- W3204522102 cites W2762963706 @default.
- W3204522102 cites W2777824604 @default.
- W3204522102 cites W2793765341 @default.
- W3204522102 cites W2804574021 @default.
- W3204522102 cites W2885171918 @default.
- W3204522102 cites W2891378911 @default.
- W3204522102 cites W2891645259 @default.
- W3204522102 cites W2896809552 @default.
- W3204522102 cites W2931711728 @default.
- W3204522102 cites W2944068509 @default.
- W3204522102 cites W2944164476 @default.
- W3204522102 cites W4229780490 @default.