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- W320454093 abstract "The production of both interleukin-2 (IL-2) and gamma interferon (IFN-{gamma}) was determined in lymphocyte preparations from spleens of copper-deficient ({minus}Cu) and copper adequate control (+Cu) mice. Swiss albino mice were fed a diet low in copper. The +Cu mice drank water with copper added, while {minus}Cu mice drank deionized water. Compared to +Cu controls, {minus}Cu mice had lower hematocrits, reduced levels of liver Cu, low plasma ceruloplasmin activity, and higher levels of liver iron. Production of IL-2 was assessed by the response of an IL-2-dependent cell line (CTLL) to serial dilutions of Con A-stimulated splenic lymphocyte culture supernatants. IFN-{gamma} levels were determined in these same supernatants by an enzyme-linked immunosorbant assay. Analysis indicated that IL-2 production by splenic lymphocytes from {minus}Cu mice was only 62% of the mean +Cu value. IFN-{gamma} levels of {minus}Cu and +Cu splenic lymphocytes, on the other hand, were equivalent. These data indicate differential effects of copper deficiency on two distinct lymphokines elaborated by the same murine T-help subpopulation, T{sub H}1." @default.
- W320454093 created "2016-06-24" @default.
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- W320454093 date "1991-03-15" @default.
- W320454093 modified "2023-09-23" @default.
- W320454093 title "Normal gamma interferon (IFN-. gamma. ) and decreased interleukin-2 (IL-2) production by copper-deficient mice" @default.
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