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- W3204558303 abstract "Tetracyclines (TCs) are the main antibiotics applied to livestock; their excessive use can lead to the appearance of their residues in milk. Therefore, regulatory entities established maximum residue limits (MRLs) to ensure food safety. However, the impacts of TCs on milk proteins are unknown. We evaluated in vitro carbonylation of caseins and whey proteins induced by four TCs at their MRLs and their effects on solubility and digestibility of these proteins, which exhibited irreversible carbonylation in most of the spiked samples, showing significantly greater carbonyl indexes than the blank (P < 0.05). Chlortetracycline and tetracycline at their MRLs induced the greatest carbonylation on caseins and whey proteins. TC-induced carbonylation promoted a significant loss of solubility for both protein fractions and reduced gastric and intestinal β-lactoglobulin digestion in whey (P < 0.05), suggesting that TC-induced carbonylation can affect the nutritional value of milk and challenge the real innocuity of MRLs for these substances." @default.
- W3204558303 created "2021-10-11" @default.
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- W3204558303 date "2022-02-01" @default.
- W3204558303 modified "2023-10-01" @default.
- W3204558303 title "Tetracycline residues induce carbonylation of milk proteins and alter their solubility and digestibility" @default.
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- W3204558303 doi "https://doi.org/10.1016/j.idairyj.2021.105226" @default.
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