FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204560242> ?p ?o ?g. }

• W3204560242 abstract "As a prevalent type of cryptogenic fibrotic disease with high mortality, idiopathic pulmonary fibrosis (IPF) still lacks effective therapeutic drugs. The compounds extracted from buds and flowers of Chrysanthemum indicum Linné with supercritical-carbon dioxide fluid (CISCFE) has been confirmed to have antioxidant, anti-inflammatory, and lung-protective effects. This paper aimed to clarify whether CISCFE could treat IPF induced by bleomycin (BLM) and elucidate the related mechanisms.Rats (Sprague-Dawley, male) were separated into the following groups: normal, model, pirfenidone (50 mg/kg), CISCFE-L, -M, and -H (240, 360, and 480 mg/kg/d, i.g., respectively, for 4 weeks). Rats were given BLM (5 mg/kg) via intratracheal installation to establish the IPF model. A549 and MRC-5 cells were stimulated by Wnt-1 to establish a cell model and then treated with CISCFE. Haematoxylin-eosin (H&E) and Masson staining were employed to observe lesions in the lung tissues. Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot (WB) were performed to observe changes in genes and proteins connected with the Wnt/β-catenin pathway.CISCFE inhibited the proliferation of MRC-5 cells (IC50: 2.723 ± 0.488 μg/mL) and A549 cells (IC50: 2.235 ± 0.229 μg/mL). In rats, A549 cells, and MRC-5 cells, BLM and Wnt-1 obviously induced the protein expression of α-smooth muscle actin (α-SMA), vimentin, type I collagen (collagen-I), and Nu-β-catenin. The mRNA levels of matrix metalloproteinase-3 (MMP-3) and - 9 (MMP-9), two enzymes that degrade and reshape the extracellular matrix (ECM) were also increased while those of tissue inhibitor of metalloproteinase 1 (TIMP-1) were decreased. However, CISCFE reversed the effects of BLM and Wnt-1 on the expression pattern of these proteins and genes.These findings showed that CISCFE could inhibit IPF development by activating the Wnt/β-catenin pathway and may serve as a treatment for IPF after further investigation." @default.
• W3204560242 created "2021-10-11" @default.
• W3204560242 creator A5002975495 @default.
• W3204560242 creator A5006693533 @default.
• W3204560242 creator A5037434096 @default.
• W3204560242 creator A5041499457 @default.
• W3204560242 creator A5046991060 @default.
• W3204560242 creator A5053559346 @default.
• W3204560242 creator A5067016617 @default.
• W3204560242 creator A5078206008 @default.
• W3204560242 creator A5083410699 @default.
• W3204560242 creator A5083702074 @default.
• W3204560242 creator A5091572919 @default.
• W3204560242 date "2021-09-25" @default.
• W3204560242 modified "2023-10-08" @default.
• W3204560242 title "Effect of supercritical carbon dioxide fluid extract from Chrysanthemum indicum Linné on bleomycin-induced pulmonary fibrosis" @default.
• W3204560242 cites W1598988227 @default.
• W3204560242 cites W1688167125 @default.
• W3204560242 cites W1813434155 @default.
• W3204560242 cites W1911139352 @default.
• W3204560242 cites W1981160918 @default.
• W3204560242 cites W1991782361 @default.
• W3204560242 cites W1992388324 @default.
• W3204560242 cites W1996757076 @default.
• W3204560242 cites W2006419043 @default.
• W3204560242 cites W2006718453 @default.
• W3204560242 cites W2007214988 @default.
• W3204560242 cites W2011604666 @default.
• W3204560242 cites W2013891209 @default.
• W3204560242 cites W2032194353 @default.
• W3204560242 cites W2032454442 @default.
• W3204560242 cites W2043051328 @default.
• W3204560242 cites W2050189717 @default.
• W3204560242 cites W2055271659 @default.
• W3204560242 cites W2061084931 @default.
• W3204560242 cites W2073865733 @default.
• W3204560242 cites W2075759194 @default.
• W3204560242 cites W2076996939 @default.
• W3204560242 cites W2077462602 @default.
• W3204560242 cites W2077875665 @default.
• W3204560242 cites W2084821463 @default.
• W3204560242 cites W2103170336 @default.
• W3204560242 cites W2107648723 @default.
• W3204560242 cites W2109052128 @default.
• W3204560242 cites W2116896036 @default.
• W3204560242 cites W2155937799 @default.
• W3204560242 cites W2157693596 @default.
• W3204560242 cites W2160410315 @default.
• W3204560242 cites W2171636247 @default.
• W3204560242 cites W2171696659 @default.
• W3204560242 cites W2347160894 @default.
• W3204560242 cites W2414895309 @default.
• W3204560242 cites W2465304206 @default.
• W3204560242 cites W2591313075 @default.
• W3204560242 cites W2606799292 @default.
• W3204560242 cites W2607147921 @default.
• W3204560242 cites W2613174768 @default.
• W3204560242 cites W2613915331 @default.
• W3204560242 cites W2671981991 @default.
• W3204560242 cites W2725796137 @default.
• W3204560242 cites W2726733357 @default.
• W3204560242 cites W2735265951 @default.
• W3204560242 cites W2749383244 @default.
• W3204560242 cites W2753866383 @default.
• W3204560242 cites W2791936667 @default.
• W3204560242 cites W2794071733 @default.
• W3204560242 cites W2801120540 @default.
• W3204560242 cites W2889646745 @default.
• W3204560242 cites W2923399113 @default.
• W3204560242 cites W2989923102 @default.
• W3204560242 cites W2107179563 @default.
• W3204560242 doi "https://doi.org/10.1186/s12906-021-03409-9" @default.
• W3204560242 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8464116" @default.
• W3204560242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34563177" @default.
• W3204560242 hasPublicationYear "2021" @default.
• W3204560242 type Work @default.
• W3204560242 sameAs 3204560242 @default.
• W3204560242 citedByCount "2" @default.
• W3204560242 countsByYear W32045602422022 @default.
• W3204560242 crossrefType "journal-article" @default.
• W3204560242 hasAuthorship W3204560242A5002975495 @default.
• W3204560242 hasAuthorship W3204560242A5006693533 @default.
• W3204560242 hasAuthorship W3204560242A5037434096 @default.
• W3204560242 hasAuthorship W3204560242A5041499457 @default.
• W3204560242 hasAuthorship W3204560242A5046991060 @default.
• W3204560242 hasAuthorship W3204560242A5053559346 @default.
• W3204560242 hasAuthorship W3204560242A5067016617 @default.
• W3204560242 hasAuthorship W3204560242A5078206008 @default.
• W3204560242 hasAuthorship W3204560242A5083410699 @default.
• W3204560242 hasAuthorship W3204560242A5083702074 @default.
• W3204560242 hasAuthorship W3204560242A5091572919 @default.
• W3204560242 hasBestOaLocation W32045602421 @default.
• W3204560242 hasConcept C104317684 @default.
• W3204560242 hasConcept C126322002 @default.
• W3204560242 hasConcept C137620995 @default.
• W3204560242 hasConcept C142724271 @default.
• W3204560242 hasConcept C153911025 @default.
• W3204560242 hasConcept C185592680 @default.
• W3204560242 hasConcept C190283241 @default.
• W3204560242 hasConcept C2776232574 @default.

• next