FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204577112> ?p ?o ?g. }

• W3204577112 endingPage "e2127806" @default.
• W3204577112 startingPage "e2127806" @default.
• W3204577112 abstract "The use of acellular dermal matrix (ADM) in implant-based breast reconstructions (IBBRs) is established practice. Existing evidence validating ADMs proposed advantages, including improved cosmetics and more single-stage IBBRs, is lacking.To evaluate whether IBBR with ADM results in fewer reoperations and increased health-related quality of life (HRQoL) compared with conventional IBBR without ADM.This was an open-label, multicenter, randomized clinical trial of women with primary breast cancer who planned for mastectomy and immediate IBBR, with a 2-year follow-up for all participants. Participants were enrolled at 5 breast cancer units in Sweden and the United Kingdom between 2014 and May 2017. Exclusion criteria included previous radiotherapy and neo-adjuvant chemotherapy. Data were analyzed until August 2017.Participants were allocated to immediate IBBR with or without ADM.The primary trial end point was number of reoperations at 2 years. HRQoL, a secondary end point, was measured as patient-reported outcome measures using 3 instruments from the European Organization for Research and Treatment of Cancer Quality of life Questionnaire.From start of enrollment on April 24, 2014, to close of trial on May 10, 2017, a total of 135 women were enrolled (mean [SD] age, 50.4 [9.5] years); 64 were assigned to have an IBBR procedure with ADM and 65 to the control group who had IBBR without ADM. There was no statistically significant difference between groups for the primary outcome. Of 129 patients analyzed at 2-year follow-up, 44 of 64 (69%) had at least 1 surgical event in the ADM group vs 43 of 65 (66%) in the control group. In the ADM group, 31 patients (48%) had at least 1 reoperation on the ipsilateral side vs 35 (54%) in the control group. The overall number of reoperations on the ipsilateral side were 42 and 43 respectively. Within the follow-up time of 24 months, 9 patients (14%) in the ADM group had the implant removed compared with 7 (11%) in the control group. We found no significant mean differences in postoperative patient-reported HRQoL domains, including perception of body image (mean difference, 3; 99% CI, -11 to 17; P = .57) and satisfaction with cosmetic outcome (mean difference, 8; 99% CI, -6 to 20; P = .11).Immediate IBBR with ADM did not yield fewer reoperations compared with conventional IBBR without ADM, nor was IBBR with ADM superior in terms of HRQoL or patient-reported cosmetic outcomes. Patients treated for breast cancer contemplating ADM-supported IBBR should be informed about the lack of evidence validating ADM's suggested benefits.ClinicalTrials.gov Identifier: NCT02061527." @default.
• W3204577112 created "2021-10-11" @default.
• W3204577112 creator A5017627575 @default.
• W3204577112 creator A5025336524 @default.
• W3204577112 creator A5045953017 @default.
• W3204577112 creator A5048355893 @default.
• W3204577112 creator A5067879166 @default.
• W3204577112 creator A5075557023 @default.
• W3204577112 date "2021-10-01" @default.
• W3204577112 modified "2023-10-02" @default.
• W3204577112 title "Effect of Immediate Implant-Based Breast Reconstruction After Mastectomy With and Without Acellular Dermal Matrix Among Women With Breast Cancer" @default.
• W3204577112 cites W1900354372 @default.
• W3204577112 cites W1947168884 @default.
• W3204577112 cites W1972062827 @default.
• W3204577112 cites W1976799363 @default.
• W3204577112 cites W2010127350 @default.
• W3204577112 cites W2021073559 @default.
• W3204577112 cites W2029217326 @default.
• W3204577112 cites W2034389991 @default.
• W3204577112 cites W2049451927 @default.
• W3204577112 cites W2064113110 @default.
• W3204577112 cites W2074261473 @default.
• W3204577112 cites W2078570470 @default.
• W3204577112 cites W2084552620 @default.
• W3204577112 cites W2087149769 @default.
• W3204577112 cites W2137473134 @default.
• W3204577112 cites W2167571044 @default.
• W3204577112 cites W2315477862 @default.
• W3204577112 cites W2331915349 @default.
• W3204577112 cites W2400201319 @default.
• W3204577112 cites W2563226059 @default.
• W3204577112 cites W2620682915 @default.
• W3204577112 cites W2744467731 @default.
• W3204577112 cites W2767889231 @default.
• W3204577112 cites W2887333496 @default.
• W3204577112 cites W2896814255 @default.
• W3204577112 cites W2990784957 @default.
• W3204577112 cites W3047032963 @default.
• W3204577112 cites W3084694838 @default.
• W3204577112 cites W3094474187 @default.
• W3204577112 cites W4213248922 @default.
• W3204577112 cites W4236302795 @default.
• W3204577112 cites W4247983054 @default.
• W3204577112 cites W4292528167 @default.
• W3204577112 cites W980279331 @default.
• W3204577112 doi "https://doi.org/10.1001/jamanetworkopen.2021.27806" @default.
• W3204577112 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8486981" @default.
• W3204577112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34596671" @default.
• W3204577112 hasPublicationYear "2021" @default.
• W3204577112 type Work @default.
• W3204577112 sameAs 3204577112 @default.
• W3204577112 citedByCount "18" @default.
• W3204577112 countsByYear W32045771122021 @default.
• W3204577112 countsByYear W32045771122022 @default.
• W3204577112 countsByYear W32045771122023 @default.
• W3204577112 crossrefType "journal-article" @default.
• W3204577112 hasAuthorship W3204577112A5017627575 @default.
• W3204577112 hasAuthorship W3204577112A5025336524 @default.
• W3204577112 hasAuthorship W3204577112A5045953017 @default.
• W3204577112 hasAuthorship W3204577112A5048355893 @default.
• W3204577112 hasAuthorship W3204577112A5067879166 @default.
• W3204577112 hasAuthorship W3204577112A5075557023 @default.
• W3204577112 hasBestOaLocation W32045771121 @default.
• W3204577112 hasConcept C121608353 @default.
• W3204577112 hasConcept C126322002 @default.
• W3204577112 hasConcept C141071460 @default.
• W3204577112 hasConcept C159110408 @default.
• W3204577112 hasConcept C168563851 @default.
• W3204577112 hasConcept C203092338 @default.
• W3204577112 hasConcept C2777757722 @default.
• W3204577112 hasConcept C2779951463 @default.
• W3204577112 hasConcept C2781001896 @default.
• W3204577112 hasConcept C2781411149 @default.
• W3204577112 hasConcept C530470458 @default.
• W3204577112 hasConcept C535046627 @default.
• W3204577112 hasConcept C71924100 @default.
• W3204577112 hasConceptScore W3204577112C121608353 @default.
• W3204577112 hasConceptScore W3204577112C126322002 @default.
• W3204577112 hasConceptScore W3204577112C141071460 @default.
• W3204577112 hasConceptScore W3204577112C159110408 @default.
• W3204577112 hasConceptScore W3204577112C168563851 @default.
• W3204577112 hasConceptScore W3204577112C203092338 @default.
• W3204577112 hasConceptScore W3204577112C2777757722 @default.
• W3204577112 hasConceptScore W3204577112C2779951463 @default.
• W3204577112 hasConceptScore W3204577112C2781001896 @default.
• W3204577112 hasConceptScore W3204577112C2781411149 @default.
• W3204577112 hasConceptScore W3204577112C530470458 @default.
• W3204577112 hasConceptScore W3204577112C535046627 @default.
• W3204577112 hasConceptScore W3204577112C71924100 @default.
• W3204577112 hasIssue "10" @default.
• W3204577112 hasLocation W32045771121 @default.
• W3204577112 hasLocation W32045771122 @default.
• W3204577112 hasLocation W32045771123 @default.
• W3204577112 hasLocation W32045771124 @default.
• W3204577112 hasOpenAccess W3204577112 @default.
• W3204577112 hasPrimaryLocation W32045771121 @default.
• W3204577112 hasRelatedWork W1984230225 @default.
• W3204577112 hasRelatedWork W1997493124 @default.

• next