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- W3204593931 abstract "The role of childhood trauma in the development of borderline personality disorder (BPD) in young age has long been studied. The most accurate theoretical models are multifactorial, taking into account a range of factors, including early trauma, to explain evolutionary pathways of BPD. We reviewed studies published on PubMed in the last 20 years to evaluate whether different types of childhood trauma, like sexual and physical abuse and neglect, increase the risk and shape the clinical picture of BPD. BPD as a sequela of childhood traumas often occurs with multiple comorbidities (e.g. mood, anxiety, obsessive-compulsive, eating, dissociative, addictive, psychotic, and somatoform disorders). In such cases it tends to have a prolonged course, to be severe, and treatment-refractory. In comparison with subjects who suffer from other personality disorders, patients with BPD experience childhood abuse more frequently. Adverse childhood experiences affect different biological systems (HPA axis, neurotransmission mechanisms, endogenous opioid systems, gray matter volume, white matter connectivity), with changes persisting into adulthood. A growing body of evidence is emerging about interaction between genes (e.g. FKBP5 polymorphisms and CRHR2 variants) and environment (physical and sexual abuse, emotional neglect)." @default.
- W3204593931 created "2021-10-11" @default.
- W3204593931 creator A5008390178 @default.
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- W3204593931 creator A5076709952 @default.
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- W3204593931 creator A5090363856 @default.
- W3204593931 date "2021-09-23" @default.
- W3204593931 modified "2023-09-30" @default.
- W3204593931 title "The Role of Trauma in Early Onset Borderline Personality Disorder: A Biopsychosocial Perspective" @default.
- W3204593931 cites W1538189973 @default.
- W3204593931 cites W1904207183 @default.
- W3204593931 cites W1967702107 @default.
- W3204593931 cites W1974054231 @default.
- W3204593931 cites W1976555196 @default.
- W3204593931 cites W1979030611 @default.
- W3204593931 cites W1989319447 @default.
- W3204593931 cites W1989844817 @default.
- W3204593931 cites W1992632762 @default.
- W3204593931 cites W1993725892 @default.
- W3204593931 cites W1995838502 @default.
- W3204593931 cites W1997589318 @default.
- W3204593931 cites W1998099908 @default.
- W3204593931 cites W2003822680 @default.
- W3204593931 cites W2003835284 @default.
- W3204593931 cites W2004458660 @default.
- W3204593931 cites W2010523062 @default.
- W3204593931 cites W2011811675 @default.
- W3204593931 cites W2021365730 @default.
- W3204593931 cites W2030248272 @default.
- W3204593931 cites W2033201884 @default.
- W3204593931 cites W2034405710 @default.
- W3204593931 cites W2038682984 @default.
- W3204593931 cites W2042181913 @default.
- W3204593931 cites W2043800213 @default.
- W3204593931 cites W2044109612 @default.
- W3204593931 cites W2045217506 @default.
- W3204593931 cites W2046136208 @default.
- W3204593931 cites W2046398833 @default.
- W3204593931 cites W2046612400 @default.
- W3204593931 cites W2053559881 @default.
- W3204593931 cites W2054282651 @default.
- W3204593931 cites W2056086615 @default.
- W3204593931 cites W2056872447 @default.
- W3204593931 cites W2058589840 @default.
- W3204593931 cites W2062922778 @default.
- W3204593931 cites W2064212981 @default.
- W3204593931 cites W2064970989 @default.
- W3204593931 cites W2068221498 @default.
- W3204593931 cites W2068470537 @default.
- W3204593931 cites W2073287346 @default.
- W3204593931 cites W2073408209 @default.
- W3204593931 cites W2088842558 @default.
- W3204593931 cites W2089974511 @default.
- W3204593931 cites W2090745865 @default.
- W3204593931 cites W2099508914 @default.
- W3204593931 cites W2101472312 @default.
- W3204593931 cites W2105409252 @default.
- W3204593931 cites W2106344090 @default.
- W3204593931 cites W2117230740 @default.
- W3204593931 cites W2120406854 @default.
- W3204593931 cites W2123988240 @default.
- W3204593931 cites W2128198106 @default.
- W3204593931 cites W2128537971 @default.
- W3204593931 cites W2133995746 @default.
- W3204593931 cites W2134697757 @default.
- W3204593931 cites W2135221443 @default.
- W3204593931 cites W2145289591 @default.
- W3204593931 cites W2145916886 @default.
- W3204593931 cites W2149094789 @default.
- W3204593931 cites W2150042510 @default.
- W3204593931 cites W2153328345 @default.
- W3204593931 cites W2154835685 @default.
- W3204593931 cites W2154870167 @default.
- W3204593931 cites W2154991689 @default.
- W3204593931 cites W2159103071 @default.
- W3204593931 cites W2159438744 @default.
- W3204593931 cites W2161813267 @default.
- W3204593931 cites W2164039729 @default.
- W3204593931 cites W2168979894 @default.
- W3204593931 cites W2266025763 @default.
- W3204593931 cites W2342081828 @default.
- W3204593931 cites W2515101995 @default.
- W3204593931 cites W2625994392 @default.
- W3204593931 cites W2626022253 @default.
- W3204593931 cites W2746214418 @default.
- W3204593931 cites W2751434469 @default.
- W3204593931 cites W2792928199 @default.
- W3204593931 cites W2885924996 @default.
- W3204593931 cites W2889588615 @default.
- W3204593931 cites W2907616080 @default.
- W3204593931 cites W2914655535 @default.
- W3204593931 cites W2971491266 @default.
- W3204593931 cites W2981044062 @default.
- W3204593931 cites W3023956662 @default.
- W3204593931 cites W3046520130 @default.
- W3204593931 cites W3082778670 @default.
- W3204593931 cites W3087373544 @default.
- W3204593931 cites W3097670913 @default.
- W3204593931 cites W4241953388 @default.