Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204604052> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W3204604052 abstract "Neutrophils are significant players in both acute and chronic inflammatory conditions, and function in infectious and autoimmune ailments. MicroRNAs regulate homeostasis in health and disease by fine tuning the expression of a network of genes through post transcriptional regulation. Many microRNAs are expressed in restricted tissues, regulated by physiological conditions such as stress and disease, and are emerging as mediators for intercellular communication that shape the tissue environments. MicroRNA profiles have been recently utilized as biomarkers for diagnosis and prognostic purposes for their stability in plasma and significant correlation with the disease progress. In addition, several microRNAs are in clinical trials for infectious diseases, cardiovascular disorders and cancer. As for neutrophil biology, microRNAs that regulate hematopoiesis and neutrophil development are well known. However, only a few microRNAs are characterized in the context of neutrophil migration and activation by loss of function studies either in mice or in cell culture. In this work we characterize the role of total microRNA regulation on neutrophil function through whole body and neutrophil specific Dicer1 knockout, and identify a microRNA regulator of neutrophil motility. MiR-722 downregulates the transcript level of rac2 through binding to a seed match in the rac2 3'UTR. Furthermore, miR-722 over-expressing larvae display improved outcomes in both sterile and bacterial systemic models. Finally, the miR-722 mimics protect zebrafish from lethal LPS challenge, providing evidence and mechanism of an anti-inflammatory microRNA that restrains detrimental systemic inflammation. We further investigated the role of the inflammatory response in an ischemia-reperfusion model. Extensive future work is required, especially in animal models, to illustrate the pivotal and complex microRNA mediated regulatory network in neutrophils, which is expected to provide the foundation for highly selective microRNA based therapy to control neutrophil behavior in infection and inflammatory disorders." @default.
- W3204604052 created "2021-10-11" @default.
- W3204604052 creator A5084726349 @default.
- W3204604052 date "2019-01-16" @default.
- W3204604052 modified "2023-09-27" @default.
- W3204604052 title "MicroRNA Regulation of Neutrophil Function" @default.
- W3204604052 doi "https://doi.org/10.25394/pgs.7437728.v1" @default.
- W3204604052 hasPublicationYear "2019" @default.
- W3204604052 type Work @default.
- W3204604052 sameAs 3204604052 @default.
- W3204604052 citedByCount "0" @default.
- W3204604052 crossrefType "dissertation" @default.
- W3204604052 hasAuthorship W3204604052A5084726349 @default.
- W3204604052 hasConcept C104317684 @default.
- W3204604052 hasConcept C119056186 @default.
- W3204604052 hasConcept C145059251 @default.
- W3204604052 hasConcept C151730666 @default.
- W3204604052 hasConcept C203014093 @default.
- W3204604052 hasConcept C2776914184 @default.
- W3204604052 hasConcept C2779343474 @default.
- W3204604052 hasConcept C502942594 @default.
- W3204604052 hasConcept C54355233 @default.
- W3204604052 hasConcept C86803240 @default.
- W3204604052 hasConcept C95444343 @default.
- W3204604052 hasConceptScore W3204604052C104317684 @default.
- W3204604052 hasConceptScore W3204604052C119056186 @default.
- W3204604052 hasConceptScore W3204604052C145059251 @default.
- W3204604052 hasConceptScore W3204604052C151730666 @default.
- W3204604052 hasConceptScore W3204604052C203014093 @default.
- W3204604052 hasConceptScore W3204604052C2776914184 @default.
- W3204604052 hasConceptScore W3204604052C2779343474 @default.
- W3204604052 hasConceptScore W3204604052C502942594 @default.
- W3204604052 hasConceptScore W3204604052C54355233 @default.
- W3204604052 hasConceptScore W3204604052C86803240 @default.
- W3204604052 hasConceptScore W3204604052C95444343 @default.
- W3204604052 hasLocation W32046040521 @default.
- W3204604052 hasOpenAccess W3204604052 @default.
- W3204604052 hasPrimaryLocation W32046040521 @default.
- W3204604052 hasRelatedWork W1495492151 @default.
- W3204604052 hasRelatedWork W1912150073 @default.
- W3204604052 hasRelatedWork W1966787692 @default.
- W3204604052 hasRelatedWork W1993329572 @default.
- W3204604052 hasRelatedWork W2012409954 @default.
- W3204604052 hasRelatedWork W2038032358 @default.
- W3204604052 hasRelatedWork W2078704378 @default.
- W3204604052 hasRelatedWork W20927463 @default.
- W3204604052 hasRelatedWork W2103193559 @default.
- W3204604052 hasRelatedWork W2123772410 @default.
- W3204604052 hasRelatedWork W2399138914 @default.
- W3204604052 hasRelatedWork W2405920214 @default.
- W3204604052 hasRelatedWork W2501008789 @default.
- W3204604052 hasRelatedWork W2587877698 @default.
- W3204604052 hasRelatedWork W2876684077 @default.
- W3204604052 hasRelatedWork W2970645924 @default.
- W3204604052 hasRelatedWork W3029410913 @default.
- W3204604052 hasRelatedWork W3082706973 @default.
- W3204604052 hasRelatedWork W3180489560 @default.
- W3204604052 hasRelatedWork W345327722 @default.
- W3204604052 isParatext "false" @default.
- W3204604052 isRetracted "false" @default.
- W3204604052 magId "3204604052" @default.
- W3204604052 workType "dissertation" @default.