Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204604931> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W3204604931 abstract "Abstract Acute pancreatitis is the most common iatrogenic dilemma of endoscopic retrograde cholangiopancreatography, and it is associated with significant morbidity and mortality. Several factors have been implicated in the pathogenesis of post-endoscopic retrograde cholangiopancreatography pancreatitis, and preventive measures were practiced accordingly. This study aims to refine the potential mechanisms that trigger post-endoscopic retrograde cholangiopancreatography pancreatitis and define the role of enteropeptidase in the pathogenesis of post-endoscopic retrograde cholangiopancreatography pancreatitis. Furthermore, address the role of a new novel medication known as SCO-792, a potent enteropeptidase inhibitor, in the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. Post-endoscopic retrograde cholangiopancreatography pancreatitis is caused by premature activation of the pancreatic enzymes within the pancreatic parenchyma. This activation is either an autoactivation due to direct provocation of intra-acinar enzymes as a result of the procedure or due to activation by enterpeptidase, a rate-limiting enzyme. Endoscopic retrograde cholangiopancreatography interjects duodenal juice that is rich in enterokinase into the pancreatic-biliary tract, which in turn leads to intra-ductal activation of trypsinogen and subsequent enzymes. Given the vital role of enterokinase in initiating the pathogenesis of pancreatitis, enteropeptidase inhibition may prevent and reduce the severity of post-endoscopic retrograde cholangiopancreatography pancreatitis. SCO-792, a novel enteropeptidase inhibitor, is developed by SCOHIA Pharma, and pre-clinical trials confirmed its efficacy in inhibiting enteropeptidase. Studies are needed to confirm the efficacy of enteropeptidase inhibitors in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis." @default.
- W3204604931 created "2021-10-11" @default.
- W3204604931 creator A5003565920 @default.
- W3204604931 creator A5007512843 @default.
- W3204604931 date "2021-10-06" @default.
- W3204604931 modified "2023-09-26" @default.
- W3204604931 title "Role of SCO-792, A Novel Enteropeptidase Inhibitor, In the Prevention of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis" @default.
- W3204604931 cites W1558814513 @default.
- W3204604931 cites W1786647014 @default.
- W3204604931 cites W1843329329 @default.
- W3204604931 cites W1967246198 @default.
- W3204604931 cites W1972036508 @default.
- W3204604931 cites W2005426660 @default.
- W3204604931 cites W2008780832 @default.
- W3204604931 cites W2014028746 @default.
- W3204604931 cites W2017906988 @default.
- W3204604931 cites W2018498377 @default.
- W3204604931 cites W2024902854 @default.
- W3204604931 cites W2024974112 @default.
- W3204604931 cites W2037929984 @default.
- W3204604931 cites W2047320764 @default.
- W3204604931 cites W2101748226 @default.
- W3204604931 cites W2102762329 @default.
- W3204604931 cites W2164069984 @default.
- W3204604931 cites W2168046530 @default.
- W3204604931 cites W2280503798 @default.
- W3204604931 cites W2320210611 @default.
- W3204604931 cites W2328583969 @default.
- W3204604931 cites W2909344377 @default.
- W3204604931 cites W2972277754 @default.
- W3204604931 cites W2996900754 @default.
- W3204604931 cites W3117004391 @default.
- W3204604931 cites W4230057285 @default.
- W3204604931 cites W4232230702 @default.
- W3204604931 cites W1996092373 @default.
- W3204604931 doi "https://doi.org/10.1055/s-0041-1736411" @default.
- W3204604931 hasPublicationYear "2021" @default.
- W3204604931 type Work @default.
- W3204604931 sameAs 3204604931 @default.
- W3204604931 citedByCount "0" @default.
- W3204604931 crossrefType "journal-article" @default.
- W3204604931 hasAuthorship W3204604931A5003565920 @default.
- W3204604931 hasAuthorship W3204604931A5007512843 @default.
- W3204604931 hasConcept C104317684 @default.
- W3204604931 hasConcept C123894998 @default.
- W3204604931 hasConcept C126322002 @default.
- W3204604931 hasConcept C145508813 @default.
- W3204604931 hasConcept C181199279 @default.
- W3204604931 hasConcept C2775967933 @default.
- W3204604931 hasConcept C2776670229 @default.
- W3204604931 hasConcept C2778444009 @default.
- W3204604931 hasConcept C2780340462 @default.
- W3204604931 hasConcept C2781286802 @default.
- W3204604931 hasConcept C40767141 @default.
- W3204604931 hasConcept C55493867 @default.
- W3204604931 hasConcept C71924100 @default.
- W3204604931 hasConcept C86803240 @default.
- W3204604931 hasConcept C90924648 @default.
- W3204604931 hasConceptScore W3204604931C104317684 @default.
- W3204604931 hasConceptScore W3204604931C123894998 @default.
- W3204604931 hasConceptScore W3204604931C126322002 @default.
- W3204604931 hasConceptScore W3204604931C145508813 @default.
- W3204604931 hasConceptScore W3204604931C181199279 @default.
- W3204604931 hasConceptScore W3204604931C2775967933 @default.
- W3204604931 hasConceptScore W3204604931C2776670229 @default.
- W3204604931 hasConceptScore W3204604931C2778444009 @default.
- W3204604931 hasConceptScore W3204604931C2780340462 @default.
- W3204604931 hasConceptScore W3204604931C2781286802 @default.
- W3204604931 hasConceptScore W3204604931C40767141 @default.
- W3204604931 hasConceptScore W3204604931C55493867 @default.
- W3204604931 hasConceptScore W3204604931C71924100 @default.
- W3204604931 hasConceptScore W3204604931C86803240 @default.
- W3204604931 hasConceptScore W3204604931C90924648 @default.
- W3204604931 hasLocation W32046049311 @default.
- W3204604931 hasOpenAccess W3204604931 @default.
- W3204604931 hasPrimaryLocation W32046049311 @default.
- W3204604931 hasRelatedWork W10733417 @default.
- W3204604931 hasRelatedWork W16630176 @default.
- W3204604931 hasRelatedWork W1679483 @default.
- W3204604931 hasRelatedWork W16865391 @default.
- W3204604931 hasRelatedWork W17556305 @default.
- W3204604931 hasRelatedWork W17999610 @default.
- W3204604931 hasRelatedWork W18403195 @default.
- W3204604931 hasRelatedWork W19387621 @default.
- W3204604931 hasRelatedWork W3598928 @default.
- W3204604931 hasRelatedWork W4314310 @default.
- W3204604931 isParatext "false" @default.
- W3204604931 isRetracted "false" @default.
- W3204604931 magId "3204604931" @default.
- W3204604931 workType "article" @default.