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- W3204605304 abstract "Recent data show that parasites manipulate the physiology of mosquitoes and human hosts to increase the probability of transmission. Here, we investigate phagostimulant activity of Plasmodium-metabolite, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), in the primary vectors of multiple human diseases, Anopheles coluzzii, An. arabiensis, An. gambiae s.s., Aedes aegypti, and Culex pipiens/Culex torrentium complex species. The addition of 10 µM HMBPP to blood meals significantly increased feeding in all the species investigated. Moreover, HMBPP also exhibited a phagostimulant property in plant-based-artificial-feeding-solution made of beetroot juice adjusted to neutral pH similar to that of blood. The addition of AlbuMAXTM as a lipid/protein source significantly improved the feeding rate of An. gambiae s.l. females providing optimised plant-based-artificial-feeding-solution for delivery toxins to control vector populations. Among natural and synthetic toxins tested, only fipronil sulfone did not reduce feeding. Overall, the toxic-plant-based-artificial-feeding-solution showed potential as an effector in environmentally friendly vector-control strategies." @default.
- W3204605304 created "2021-10-11" @default.
- W3204605304 creator A5006701486 @default.
- W3204605304 creator A5025779244 @default.
- W3204605304 creator A5061835232 @default.
- W3204605304 creator A5081574699 @default.
- W3204605304 creator A5084012365 @default.
- W3204605304 date "2021-10-07" @default.
- W3204605304 modified "2023-10-16" @default.
- W3204605304 title "Plasmodium metabolite HMBPP stimulates feeding of main mosquito vectors on blood and artificial toxic sources" @default.
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- W3204605304 doi "https://doi.org/10.1038/s42003-021-02689-8" @default.
- W3204605304 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8497504" @default.
- W3204605304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34620990" @default.
- W3204605304 hasPublicationYear "2021" @default.
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