Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204607842> ?p ?o ?g. }
- W3204607842 abstract "Glucosyltransferases (Gtfs) play critical roles in the etiology and pathogenesis of Streptococcus mutans (S. mutans)- mediated dental caries including early childhood caries. Gtfs enhance the biofilm formation and promotes colonization of cariogenic bacteria by generating biofilm extracellular polysaccharides (EPSs), the key virulence property in the cariogenic process. Therefore, Gtfs have become an appealing target for effective therapeutic interventions that inhibit cariogenic biofilms. Importantly, targeting Gtfs selectively impairs the S. mutans virulence without affecting S. mutans existence or the existence of other species in the oral cavity. Over the past decade, numerous Gtfs inhibitory molecules have been identified, mainly including natural and synthetic compounds and their derivatives, antibodies, and metal ions. These therapeutic agents exert their inhibitory role in inhibiting the expression gtf genes and the activities and secretion of Gtfs enzymes with a wide range of sensitivity and effectiveness. Understanding molecular mechanisms of inhibiting Gtfs will contribute to instructing drug combination strategies, which is more effective for inhibiting Gtfs than one drug or class of drugs. This review highlights our current understanding of Gtfs activities and their potential utility, and discusses challenges and opportunities for future exploration of Gtfs as a therapeutic target." @default.
- W3204607842 created "2021-10-11" @default.
- W3204607842 creator A5003642180 @default.
- W3204607842 creator A5010357586 @default.
- W3204607842 creator A5041326552 @default.
- W3204607842 creator A5056002024 @default.
- W3204607842 creator A5065673727 @default.
- W3204607842 date "2021-09-30" @default.
- W3204607842 modified "2023-10-17" @default.
- W3204607842 title "Molecular mechanisms of inhibiting glucosyltransferases for biofilm formation in Streptococcus mutans" @default.
- W3204607842 cites W1584024908 @default.
- W3204607842 cites W1587553111 @default.
- W3204607842 cites W1752036286 @default.
- W3204607842 cites W1875897665 @default.
- W3204607842 cites W1879354382 @default.
- W3204607842 cites W1915401960 @default.
- W3204607842 cites W1917350117 @default.
- W3204607842 cites W1924241709 @default.
- W3204607842 cites W1938288206 @default.
- W3204607842 cites W1960657227 @default.
- W3204607842 cites W1965946877 @default.
- W3204607842 cites W1965983886 @default.
- W3204607842 cites W1968029926 @default.
- W3204607842 cites W1969854186 @default.
- W3204607842 cites W1973268693 @default.
- W3204607842 cites W1982337286 @default.
- W3204607842 cites W1982558712 @default.
- W3204607842 cites W1986893127 @default.
- W3204607842 cites W1990475454 @default.
- W3204607842 cites W1994847255 @default.
- W3204607842 cites W1997533762 @default.
- W3204607842 cites W2001061324 @default.
- W3204607842 cites W2004042217 @default.
- W3204607842 cites W2004297748 @default.
- W3204607842 cites W2004864684 @default.
- W3204607842 cites W2006609711 @default.
- W3204607842 cites W2010509896 @default.
- W3204607842 cites W2011393844 @default.
- W3204607842 cites W2013207623 @default.
- W3204607842 cites W2015167950 @default.
- W3204607842 cites W2028501958 @default.
- W3204607842 cites W2039372752 @default.
- W3204607842 cites W2047419279 @default.
- W3204607842 cites W2049438093 @default.
- W3204607842 cites W2050394160 @default.
- W3204607842 cites W2051681344 @default.
- W3204607842 cites W2054074495 @default.
- W3204607842 cites W2054108742 @default.
- W3204607842 cites W2055328189 @default.
- W3204607842 cites W2055955829 @default.
- W3204607842 cites W2058946554 @default.
- W3204607842 cites W2065007986 @default.
- W3204607842 cites W2071283757 @default.
- W3204607842 cites W2079495556 @default.
- W3204607842 cites W2079505151 @default.
- W3204607842 cites W2085154839 @default.
- W3204607842 cites W2085416031 @default.
- W3204607842 cites W2093766619 @default.
- W3204607842 cites W2095298897 @default.
- W3204607842 cites W2095421689 @default.
- W3204607842 cites W2098337498 @default.
- W3204607842 cites W2098976315 @default.
- W3204607842 cites W2099640653 @default.
- W3204607842 cites W2102483361 @default.
- W3204607842 cites W2106761599 @default.
- W3204607842 cites W2108559568 @default.
- W3204607842 cites W2108585852 @default.
- W3204607842 cites W2110294754 @default.
- W3204607842 cites W2111051779 @default.
- W3204607842 cites W2112385136 @default.
- W3204607842 cites W2112421184 @default.
- W3204607842 cites W2116893396 @default.
- W3204607842 cites W2118767295 @default.
- W3204607842 cites W2123884956 @default.
- W3204607842 cites W2128294176 @default.
- W3204607842 cites W2130394726 @default.
- W3204607842 cites W2131019161 @default.
- W3204607842 cites W2134686516 @default.
- W3204607842 cites W2136323272 @default.
- W3204607842 cites W2138307476 @default.
- W3204607842 cites W2139317209 @default.
- W3204607842 cites W2140372066 @default.
- W3204607842 cites W2144689411 @default.
- W3204607842 cites W2149628120 @default.
- W3204607842 cites W2150791944 @default.
- W3204607842 cites W2151001863 @default.
- W3204607842 cites W2154029327 @default.
- W3204607842 cites W2155050787 @default.
- W3204607842 cites W2155440710 @default.
- W3204607842 cites W2157470555 @default.
- W3204607842 cites W2162340160 @default.
- W3204607842 cites W2167484742 @default.
- W3204607842 cites W2169324675 @default.
- W3204607842 cites W2169470968 @default.
- W3204607842 cites W2169589212 @default.
- W3204607842 cites W2232427626 @default.
- W3204607842 cites W2340245337 @default.
- W3204607842 cites W2340761255 @default.
- W3204607842 cites W2349128164 @default.
- W3204607842 cites W2373229548 @default.