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• W3204609501 abstract "A history of childhood adversity is associated with psychotic disorder, with an increase in risk according to the number of exposures. However, it is not known why only some exposed individuals go on to develop psychosis. One possibility is pre-existing polygenic vulnerability. Here, we investigated, in the largest sample of first-episode psychosis (FEP) cases to date, whether childhood adversity and high polygenic risk scores for schizophrenia (SZ-PRS) combine synergistically to increase the risk of psychosis, over and above the effect of each alone.We assigned a schizophrenia-polygenic risk score (SZ-PRS), calculated from the Psychiatric Genomics Consortium (PGC2), to all participants in a sample of 384 FEP patients and 690 controls from the case-control component of the EU-GEI study. Only participants of European ancestry were included in the study. A history of childhood adversity was collected using the Childhood Trauma Questionnaire (CTQ). Synergistic effects were estimated using the interaction contrast ratio (ICR) [odds ratio (OR)exposure and PRS - ORexposure - ORPRS + 1] with adjustment for potential confounders.There was some evidence that the combined effect of childhood adversities and polygenic risk was greater than the sum of each alone, as indicated by an ICR greater than zero [i.e. ICR 1.28, 95% confidence interval (CI) -1.29 to 3.85]. Examining subtypes of childhood adversities, the strongest synergetic effect was observed for physical abuse (ICR 6.25, 95% CI -6.25 to 20.88).Our findings suggest possible synergistic effects of genetic liability and childhood adversity experiences in the onset of FEP, but larger samples are needed to increase precision of estimates." @default.
• W3204609501 created "2021-10-11" @default.
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• W3204609501 date "2021-09-29" @default.
• W3204609501 modified "2023-10-13" @default.
• W3204609501 title "Synergistic effects of childhood adversity and polygenic risk in first-episode psychosis: the EU-GEI study" @default.
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• W3204609501 cites W1826521770 @default.
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• W3204609501 cites W1973487575 @default.
• W3204609501 cites W1997338841 @default.
• W3204609501 cites W2019910485 @default.
• W3204609501 cites W2025272189 @default.
• W3204609501 cites W2035309865 @default.
• W3204609501 cites W2041474029 @default.
• W3204609501 cites W2047670069 @default.
• W3204609501 cites W2066629760 @default.
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• W3204609501 cites W2097940171 @default.
• W3204609501 cites W2098597355 @default.
• W3204609501 cites W2101357408 @default.
• W3204609501 cites W2102148853 @default.
• W3204609501 cites W2114552460 @default.
• W3204609501 cites W2114647004 @default.
• W3204609501 cites W2120902970 @default.
• W3204609501 cites W2146733388 @default.
• W3204609501 cites W2146809691 @default.
• W3204609501 cites W2149016179 @default.
• W3204609501 cites W2153876142 @default.
• W3204609501 cites W2233480823 @default.
• W3204609501 cites W2471573433 @default.
• W3204609501 cites W2486515975 @default.
• W3204609501 cites W2513402838 @default.
• W3204609501 cites W2522475603 @default.
• W3204609501 cites W2562716042 @default.
• W3204609501 cites W2569771892 @default.
• W3204609501 cites W2747461421 @default.
• W3204609501 cites W2751739125 @default.
• W3204609501 cites W2758725377 @default.
• W3204609501 cites W2760657291 @default.
• W3204609501 cites W2769997711 @default.
• W3204609501 cites W2775459139 @default.
• W3204609501 cites W2797255280 @default.
• W3204609501 cites W2801704870 @default.
• W3204609501 cites W2803640778 @default.
• W3204609501 cites W2890093470 @default.
• W3204609501 cites W2895512008 @default.
• W3204609501 cites W2908699123 @default.
• W3204609501 cites W2922855419 @default.
• W3204609501 cites W2923015624 @default.
• W3204609501 cites W2944746345 @default.
• W3204609501 cites W2948943625 @default.
• W3204609501 cites W2967343033 @default.
• W3204609501 cites W2981044875 @default.
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• W3204609501 doi "https://doi.org/10.1017/s0033291721003664" @default.
• W3204609501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37310339" @default.

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