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• W3204629042 abstract "Broadly protective vaccines against SARS-related coronaviruses that may cause future outbreaks are urgently needed. The SARS-CoV-2 spike receptor-binding domain (RBD) comprises two regions, the core-RBD and the receptor-binding motif (RBM); the former is structurally conserved between SARS-CoV-2 and SARS-CoV. Here, in order to elicit humoral responses to the more conserved core-RBD, we introduced N-linked glycans onto RBM surfaces of the SARS-CoV-2 RBD and used them as immunogens in a mouse model. We found that glycan addition elicited higher proportions of the core-RBD-specific germinal center (GC) B cells and antibody responses, thereby manifesting significant neutralizing activity for SARS-CoV, SARS-CoV-2, and the bat WIV1-CoV. These results have implications for the design of SARS-like virus vaccines." @default.
• W3204629042 created "2021-10-11" @default.
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• W3204629042 date "2021-10-08" @default.
• W3204629042 modified "2023-10-15" @default.
• W3204629042 title "Glycan engineering of the SARS-CoV-2 receptor-binding domain elicits cross-neutralizing antibodies for SARS-related viruses" @default.
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• W3204629042 doi "https://doi.org/10.1084/jem.20211003" @default.
• W3204629042 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8641255" @default.
• W3204629042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34623376" @default.
• W3204629042 hasPublicationYear "2021" @default.
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