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- W3204641882 endingPage "2588" @default.
- W3204641882 startingPage "2588" @default.
- W3204641882 abstract "Mesenchymal stem cells (MSCs) are multipotent adult stem cells present in virtually all tissues; they have a potent self-renewal capacity and can differentiate into multiple cell types. They also affect the ambient tissue by the paracrine secretion of numerous factors in vivo, including the induction of other stem cells' differentiation. In vitro, the culture media supernatant is named secretome and contains soluble molecules and extracellular vesicles that retain potent biological function in tissue regeneration. MSCs are considered safe for human treatment; their use does not involve ethical issues, as embryonic stem cells do not require genetic manipulation as induced pluripotent stem cells, and after intravenous injection, they are mainly found in the lugs. Therefore, these cells are currently being tested in various preclinical and clinical trials for several diseases, including COVID-19. Several affected COVID-19 patients develop induced acute respiratory distress syndrome (ARDS) associated with an uncontrolled inflammatory response. This condition causes extensive damage to the lungs and may leave serious post-COVID-19 sequelae. As the disease may cause systemic alterations, such as thromboembolism and compromised renal and cardiac function, the intravenous injection of MSCs may be a therapeutic alternative against multiple pathological manifestations. In this work, we reviewed the literature about MSCs biology, focusing on their function in pulmonary regeneration and their use in COVID-19 treatment." @default.
- W3204641882 created "2021-10-11" @default.
- W3204641882 creator A5010909275 @default.
- W3204641882 creator A5054699135 @default.
- W3204641882 creator A5080310506 @default.
- W3204641882 date "2021-09-29" @default.
- W3204641882 modified "2023-10-17" @default.
- W3204641882 title "Mesenchymal Stem Cells in the Treatment of COVID-19, a Promising Future" @default.
- W3204641882 cites W1555995655 @default.
- W3204641882 cites W1564862190 @default.
- W3204641882 cites W1604538830 @default.
- W3204641882 cites W1651832009 @default.
- W3204641882 cites W1779998146 @default.
- W3204641882 cites W1963501822 @default.
- W3204641882 cites W1963573444 @default.
- W3204641882 cites W1965727192 @default.
- W3204641882 cites W1965926911 @default.
- W3204641882 cites W1967524272 @default.
- W3204641882 cites W1968705499 @default.
- W3204641882 cites W1971533405 @default.
- W3204641882 cites W1974012180 @default.
- W3204641882 cites W1974911818 @default.
- W3204641882 cites W1980111231 @default.
- W3204641882 cites W1980309647 @default.
- W3204641882 cites W1983122990 @default.
- W3204641882 cites W1984807833 @default.
- W3204641882 cites W1991889240 @default.
- W3204641882 cites W1992330092 @default.
- W3204641882 cites W1995864374 @default.
- W3204641882 cites W1996482730 @default.
- W3204641882 cites W1998066488 @default.
- W3204641882 cites W1999705683 @default.
- W3204641882 cites W2001127699 @default.
- W3204641882 cites W2002325129 @default.
- W3204641882 cites W2002620928 @default.
- W3204641882 cites W2005477804 @default.
- W3204641882 cites W2009891045 @default.
- W3204641882 cites W2010096412 @default.
- W3204641882 cites W2011358857 @default.
- W3204641882 cites W2011525167 @default.
- W3204641882 cites W2014603632 @default.
- W3204641882 cites W2021474483 @default.
- W3204641882 cites W2022855248 @default.
- W3204641882 cites W2024971445 @default.
- W3204641882 cites W2025371271 @default.
- W3204641882 cites W2031790029 @default.
- W3204641882 cites W2034706779 @default.
- W3204641882 cites W2035472836 @default.
- W3204641882 cites W2036061724 @default.
- W3204641882 cites W2036348189 @default.
- W3204641882 cites W2036475825 @default.
- W3204641882 cites W2036932644 @default.
- W3204641882 cites W2037155465 @default.
- W3204641882 cites W2050100365 @default.
- W3204641882 cites W2055424631 @default.
- W3204641882 cites W2056510698 @default.
- W3204641882 cites W2059066863 @default.
- W3204641882 cites W2061560867 @default.
- W3204641882 cites W2064735925 @default.
- W3204641882 cites W2071536607 @default.
- W3204641882 cites W2071904806 @default.
- W3204641882 cites W2080554447 @default.
- W3204641882 cites W2084264980 @default.
- W3204641882 cites W2085030928 @default.
- W3204641882 cites W2093191361 @default.
- W3204641882 cites W2094024512 @default.
- W3204641882 cites W2094173082 @default.
- W3204641882 cites W2101661147 @default.
- W3204641882 cites W2106072740 @default.
- W3204641882 cites W2107503723 @default.
- W3204641882 cites W2109179710 @default.
- W3204641882 cites W2111727066 @default.
- W3204641882 cites W2112271653 @default.
- W3204641882 cites W2114066412 @default.
- W3204641882 cites W2114651025 @default.
- W3204641882 cites W2116500923 @default.
- W3204641882 cites W2122174032 @default.
- W3204641882 cites W2124056092 @default.
- W3204641882 cites W2126134953 @default.
- W3204641882 cites W2127190481 @default.
- W3204641882 cites W2133375451 @default.
- W3204641882 cites W2139390930 @default.
- W3204641882 cites W2140239301 @default.
- W3204641882 cites W2141720233 @default.
- W3204641882 cites W2144268541 @default.
- W3204641882 cites W2144795369 @default.
- W3204641882 cites W2146701605 @default.
- W3204641882 cites W2146906484 @default.
- W3204641882 cites W2147061961 @default.
- W3204641882 cites W2147156629 @default.
- W3204641882 cites W2147387850 @default.
- W3204641882 cites W2155044423 @default.
- W3204641882 cites W2158780936 @default.
- W3204641882 cites W2159400425 @default.
- W3204641882 cites W2159999899 @default.
- W3204641882 cites W2160330354 @default.
- W3204641882 cites W2161497340 @default.
- W3204641882 cites W2161704645 @default.