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- W3204647816 abstract "We thank Dr. Rossi and Dr. Rossitto for their interest in our recent publication (1, 2). The main finding of our study is that mineralocorticoid receptor antagonists (MRAs) strongly interfere with the aldosterone-to-renin ratio (ARR), leading to a high rate of false negative results in a time- and dose-dependent manner, resulting in 72.5% of missed PA diagnosis after 7 to 12 months of canrenone treatment. Dr. Rossi and Dr. Rossitto suggest a different interpretation of our findings, focusing only on the “short term MRA treatment cohort,” since the “long term cohort,” composed mainly of patients with the bilateral subtype or undetermined primary aldosteronism (PA), is, in their view, not worth diagnosing because it is not amendable to surgical correction. This assumption is against recent evidence showing that patients with bilateral PA carry an increased risk of cardio- and cerebrovascular events compared with patients with essential hypertension..." @default.
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- W3204647816 date "2021-10-05" @default.
- W3204647816 modified "2023-09-27" @default.
- W3204647816 title "Response to Letter to the Editor from Gian Paolo Rossi: ‘Mineralocorticoid receptor antagonist effect on aldosterone to renin ratio in patients with primary aldosteronism’" @default.
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- W3204647816 doi "https://doi.org/10.1210/clinem/dgab719" @default.
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