FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204648332> ?p ?o ?g. }

• W3204648332 abstract "Objective: To evaluate the efficacy and safety of different doses of sildenafil for persistent pulmonary hypertension of the newborn (PPHN) with Bayesian random effects network meta-analysis. Methods: We searched Chinese and English databases for randomized controlled trials (RCTs) concerning sildenafil in newborns with persistent pulmonary hypertension from 1998 to December 2020. Results: Twenty-two RCTs including over 2131 patients were included. Sildenafil was administered by nasal feeding at 0.3–2 mg/kg every 4–6 h. The network meta-analysis revealed that 1.5 mg/kg of sildenafil led to a significant decrease in pulmonary artery systolic pressure (PASP) compared with 0.3 and 0.6 mg/kg ( p &lt; 0.05); 1.5 mg/kg was better than 0.3, 0.5, and 1.0 mg/kg at increasing the partial pressure of oxygen (PaO 2 ) ( p &lt; 0.05); 1.5 mg/kg was better than 0.5, 0.6 and 1.0 mg/kg at reducing the partial pressure of carbon dioxide (PaCO 2 ) ( p &lt; 0.05); and 1.2 mg/kg was better than 0.3, 0.5 and 1.0 mg/kg at increasing the arterial oxygen saturation (SaO 2 ) ( p &lt; 0.05). The surface under the cumulative ranking analysis (SUCRA) results showed that 1.5 mg/kg had the best effect in reducing PASP (SUCRA = 92.0%, moderate certainty evidence) and PaCO 2 (91.1%) and increasing PaO 2 (SUCRA = 79.3%, moderate certainty evidence), 2.0 mg/kg had the best effect in increasing SaO 2 (SUCRA = 88.6%, moderate certainty evidence) and total effective rate (SUCRA = 93.5%, low certainty of evidence)). No severe adverse effects were observed with the different doses of sildenafil. Conclusion: Different doses of sildenafil can significantly improve PPHN, and 1.5 mg/kg of sildenafil has better clinical efficacy and does not increase the probability of adverse reactions." @default.
• W3204648332 created "2021-10-11" @default.
• W3204648332 creator A5039704650 @default.
• W3204648332 creator A5040158379 @default.
• W3204648332 creator A5052132687 @default.
• W3204648332 creator A5073735090 @default.
• W3204648332 creator A5087404619 @default.
• W3204648332 date "2021-09-24" @default.
• W3204648332 modified "2023-10-01" @default.
• W3204648332 title "Clinical Efficacy and Safety of Different Doses of Sildenafil in the Treatment of Persistent Pulmonary Hypertension of the Newborn: A Network Meta-analysis" @default.
• W3204648332 cites W1606855926 @default.
• W3204648332 cites W1977935902 @default.
• W3204648332 cites W2010909013 @default.
• W3204648332 cites W2023084326 @default.
• W3204648332 cites W2035563047 @default.
• W3204648332 cites W2063646125 @default.
• W3204648332 cites W2094051192 @default.
• W3204648332 cites W2125534535 @default.
• W3204648332 cites W2150376725 @default.
• W3204648332 cites W2150889420 @default.
• W3204648332 cites W2164783721 @default.
• W3204648332 cites W2178108213 @default.
• W3204648332 cites W2340008871 @default.
• W3204648332 cites W2558616340 @default.
• W3204648332 cites W2726814448 @default.
• W3204648332 cites W2895991279 @default.
• W3204648332 cites W2949111199 @default.
• W3204648332 cites W3029125641 @default.
• W3204648332 doi "https://doi.org/10.3389/fphar.2021.697287" @default.
• W3204648332 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8497971" @default.
• W3204648332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34630080" @default.
• W3204648332 hasPublicationYear "2021" @default.
• W3204648332 type Work @default.
• W3204648332 sameAs 3204648332 @default.
• W3204648332 citedByCount "3" @default.
• W3204648332 countsByYear W32046483322022 @default.
• W3204648332 countsByYear W32046483322023 @default.
• W3204648332 crossrefType "journal-article" @default.
• W3204648332 hasAuthorship W3204648332A5039704650 @default.
• W3204648332 hasAuthorship W3204648332A5040158379 @default.
• W3204648332 hasAuthorship W3204648332A5052132687 @default.
• W3204648332 hasAuthorship W3204648332A5073735090 @default.
• W3204648332 hasAuthorship W3204648332A5087404619 @default.
• W3204648332 hasBestOaLocation W32046483321 @default.
• W3204648332 hasConcept C126322002 @default.
• W3204648332 hasConcept C168563851 @default.
• W3204648332 hasConcept C2776768464 @default.
• W3204648332 hasConcept C2780930700 @default.
• W3204648332 hasConcept C2780940725 @default.
• W3204648332 hasConcept C42219234 @default.
• W3204648332 hasConcept C71924100 @default.
• W3204648332 hasConcept C84393581 @default.
• W3204648332 hasConcept C95190672 @default.
• W3204648332 hasConceptScore W3204648332C126322002 @default.
• W3204648332 hasConceptScore W3204648332C168563851 @default.
• W3204648332 hasConceptScore W3204648332C2776768464 @default.
• W3204648332 hasConceptScore W3204648332C2780930700 @default.
• W3204648332 hasConceptScore W3204648332C2780940725 @default.
• W3204648332 hasConceptScore W3204648332C42219234 @default.
• W3204648332 hasConceptScore W3204648332C71924100 @default.
• W3204648332 hasConceptScore W3204648332C84393581 @default.
• W3204648332 hasConceptScore W3204648332C95190672 @default.
• W3204648332 hasFunder F4320330206 @default.
• W3204648332 hasLocation W32046483321 @default.
• W3204648332 hasLocation W32046483322 @default.
• W3204648332 hasLocation W32046483323 @default.
• W3204648332 hasOpenAccess W3204648332 @default.
• W3204648332 hasPrimaryLocation W32046483321 @default.
• W3204648332 hasRelatedWork W139966569 @default.
• W3204648332 hasRelatedWork W1558132769 @default.
• W3204648332 hasRelatedWork W1982601738 @default.
• W3204648332 hasRelatedWork W1989870400 @default.
• W3204648332 hasRelatedWork W2016115951 @default.
• W3204648332 hasRelatedWork W2619514588 @default.
• W3204648332 hasRelatedWork W2889529591 @default.
• W3204648332 hasRelatedWork W3082514971 @default.
• W3204648332 hasRelatedWork W4232428403 @default.
• W3204648332 hasRelatedWork W2142297081 @default.
• W3204648332 hasVolume "12" @default.
• W3204648332 isParatext "false" @default.
• W3204648332 isRetracted "false" @default.
• W3204648332 magId "3204648332" @default.
• W3204648332 workType "article" @default.