FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204650063> ?p ?o ?g. }

• W3204650063 abstract "Chitosan is a polysaccharide polymer which was found abundant in marine crustacean outer skeleton. This compromising polymer was popularly used in drug delivery development and some medical applications. However, this polymer still has some imperfection such as fast release, hydrophobic surface and limited self-life properties which needs to be modified. Layer by layer (LBL) chitosan-gelatin was applied to improve some properties such as degradation rate, the contact angle of chitosan film and especially the drug leasing rate. This technique is a method which used the replication coating of chitosan and the gelatin layer by layer on top of each other. The modification provides a significant improvement. The result of analysis revealed that the contact angle of surface of modified chitosan film was improved 6% lower than chitosan film. The modification also reduced the swelling ratio of the film, which also leads to reduce around 68.8% of degradation rate of chitosan film. LBL also improves the strength 2.73 times stronger compare to single chitosan layer film. Moreover, the result from the drug releasing also confirm that the modification also reduces the releasing rate of drug releasing. By increasing the number of layers, the modification could reduce around 3% lower than rate of drug releasing of chitosan film. Furthermore, the increasing of concentration of chitosan also reduced rate of drug releasing around 40 times smaller than the rate of release of chitosan film. However, there are some adverse effects which were found during the experiment. There are reducing drug releasing efficiency significantly after increasing the number of layer and concentration. By the way, the releasing rate also define by the pH of the PBS solution in which the drug was released. These results show that LBL chitosan modification could improve significantly on degradation, contact angle and drug releasing rate. This improvement shows a promising sign for further study to improve this development.Chitosan is a polysaccharide polymer which was found abundant in marine crustacean outer skeleton. This compromising polymer was popularly used in drug delivery development and some medical applications. However, this polymer still has some imperfection such as fast release, hydrophobic surface and limited self-life properties which needs to be modified. Layer by layer (LBL) chitosan-gelatin was applied to improve some properties such as degradation rate, the contact angle of chitosan film and especially the drug leasing rate. This technique is a method which used the replication coating of chitosan and the gelatin layer by layer on top of each other. The modification provides a significant improvement. The result of analysis revealed that the contact angle of surface of modified chitosan film was improved 6% lower than chitosan film. The modification also reduced the swelling ratio of the film, which also leads to reduce around 68.8% of degradation rate of chitosan film. LBL also improves the strength 2.73 times stronger compare to single chitosan layer film. Moreover, the result from the drug releasing also confirm that the modification also reduces the releasing rate of drug releasing. By increasing the number of layers, the modification could reduce around 3% lower than rate of drug releasing of chitosan film. Furthermore, the increasing of concentration of chitosan also reduced rate of drug releasing around 40 times smaller than the rate of release of chitosan film. However, there are some adverse effects which were found during the experiment. There are reducing drug releasing efficiency significantly after increasing the number of layer and concentration. By the way, the releasing rate also define by the pH of the PBS solution in which the drug was released. These results show that LBL chitosan modification could improve significantly on degradation, contact angle and drug releasing rate. This improvement shows a promising sign for further study to improve this development." @default.
• W3204650063 created "2021-10-11" @default.
• W3204650063 creator A5025337043 @default.
• W3204650063 creator A5051554579 @default.
• W3204650063 creator A5058633836 @default.
• W3204650063 date "2018-01-01" @default.
• W3204650063 modified "2023-09-26" @default.
• W3204650063 title "Effect of layer-by-layer chitosan-gelatin modification on physical properties and drug-controlled release properties" @default.
• W3204650063 hasPublicationYear "2018" @default.
• W3204650063 type Work @default.
• W3204650063 sameAs 3204650063 @default.
• W3204650063 citedByCount "0" @default.
• W3204650063 crossrefType "journal-article" @default.
• W3204650063 hasAuthorship W3204650063A5025337043 @default.
• W3204650063 hasAuthorship W3204650063A5051554579 @default.
• W3204650063 hasAuthorship W3204650063A5058633836 @default.
• W3204650063 hasConcept C115537861 @default.
• W3204650063 hasConcept C127413603 @default.
• W3204650063 hasConcept C159985019 @default.
• W3204650063 hasConcept C171250308 @default.
• W3204650063 hasConcept C178790620 @default.
• W3204650063 hasConcept C185592680 @default.
• W3204650063 hasConcept C192562407 @default.
• W3204650063 hasConcept C2778540859 @default.
• W3204650063 hasConcept C2778823387 @default.
• W3204650063 hasConcept C2779227376 @default.
• W3204650063 hasConcept C2779732960 @default.
• W3204650063 hasConcept C2779820397 @default.
• W3204650063 hasConcept C2781448156 @default.
• W3204650063 hasConcept C42360764 @default.
• W3204650063 hasConcept C521977710 @default.
• W3204650063 hasConcept C62960913 @default.
• W3204650063 hasConcept C6556556 @default.
• W3204650063 hasConceptScore W3204650063C115537861 @default.
• W3204650063 hasConceptScore W3204650063C127413603 @default.
• W3204650063 hasConceptScore W3204650063C159985019 @default.
• W3204650063 hasConceptScore W3204650063C171250308 @default.
• W3204650063 hasConceptScore W3204650063C178790620 @default.
• W3204650063 hasConceptScore W3204650063C185592680 @default.
• W3204650063 hasConceptScore W3204650063C192562407 @default.
• W3204650063 hasConceptScore W3204650063C2778540859 @default.
• W3204650063 hasConceptScore W3204650063C2778823387 @default.
• W3204650063 hasConceptScore W3204650063C2779227376 @default.
• W3204650063 hasConceptScore W3204650063C2779732960 @default.
• W3204650063 hasConceptScore W3204650063C2779820397 @default.
• W3204650063 hasConceptScore W3204650063C2781448156 @default.
• W3204650063 hasConceptScore W3204650063C42360764 @default.
• W3204650063 hasConceptScore W3204650063C521977710 @default.
• W3204650063 hasConceptScore W3204650063C62960913 @default.
• W3204650063 hasConceptScore W3204650063C6556556 @default.
• W3204650063 hasLocation W32046500631 @default.
• W3204650063 hasOpenAccess W3204650063 @default.
• W3204650063 hasPrimaryLocation W32046500631 @default.
• W3204650063 hasRelatedWork W1971094772 @default.
• W3204650063 hasRelatedWork W1986395478 @default.
• W3204650063 hasRelatedWork W2070071981 @default.
• W3204650063 hasRelatedWork W2124697965 @default.
• W3204650063 hasRelatedWork W2188373476 @default.
• W3204650063 hasRelatedWork W2360278119 @default.
• W3204650063 hasRelatedWork W2372257448 @default.
• W3204650063 hasRelatedWork W2426786089 @default.
• W3204650063 hasRelatedWork W2802183313 @default.
• W3204650063 hasRelatedWork W2963353573 @default.
• W3204650063 hasRelatedWork W3093715622 @default.
• W3204650063 hasRelatedWork W3193441583 @default.
• W3204650063 hasRelatedWork W3204736385 @default.
• W3204650063 hasRelatedWork W2181703567 @default.
• W3204650063 hasRelatedWork W2182638518 @default.
• W3204650063 hasRelatedWork W2182809140 @default.
• W3204650063 hasRelatedWork W2188055391 @default.
• W3204650063 hasRelatedWork W2847459322 @default.
• W3204650063 hasRelatedWork W2869877306 @default.
• W3204650063 hasRelatedWork W2879201344 @default.
• W3204650063 isParatext "false" @default.
• W3204650063 isRetracted "false" @default.
• W3204650063 magId "3204650063" @default.
• W3204650063 workType "article" @default.