Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204654219> ?p ?o ?g. }
- W3204654219 abstract "Atherosclerosis (AS) is the main pathological cause of acute cardiovascular and cerebrovascular diseases, such as acute myocardial infarction and cerebral apoplexy. As an immune-mediated inflammatory disease, the pathogenesis of AS involves endothelial cell dysfunction, lipid accumulation, foam cell formation, vascular smooth muscle cell (VSMC) migration, and inflammatory factor infiltration. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) plays an important role in lipid metabolism, inflammation, and apoptosis by antagonizing the Wnt/β-catenin pathway and regulating cholesterol efflux and inflammatory factors. Importantly, PPARγ-dependant fatty acid uptake is critical for metabolic programming. Activated PPARγ can exert an anti-atherosclerotic effect by inhibiting the expression of various inflammatory factors, improving endothelial cell function, and restraining the proliferation and migration of VSMCs. Regulatory T cells (Tregs) are the only subset of T lymphocytes that have a completely negative regulatory effect on the autoimmune response. They play a critical role in suppressing excessive immune responses and inflammatory reactions and widely affect AS-associated foam cell formation, plaque rupture, and other processes. Recent studies have shown that PPARγ activation promotes the recruitment of Tregs to reduce inflammation, thereby exerting its anti-atherosclerotic effect. In this review, we provide an overview of the anti-AS roles of PPARγ and Tregs by discussing their pathological mechanisms from the perspective of AS and immune-mediated inflammation, with a focus on basic research and clinical trials of their efficacies alone or in combination in inhibiting atherosclerotic inflammation. Additionally, we explore new ideas for AS treatment and plaque stabilization and establish a foundation for the development of natural PPARγ agonists with Treg recruitment capability." @default.
- W3204654219 created "2021-10-11" @default.
- W3204654219 creator A5001817205 @default.
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- W3204654219 creator A5075392356 @default.
- W3204654219 creator A5079949674 @default.
- W3204654219 date "2021-09-29" @default.
- W3204654219 modified "2023-10-14" @default.
- W3204654219 title "Mechanistic Insight into PPARγ and Tregs in Atherosclerotic Immune Inflammation" @default.
- W3204654219 cites W119107369 @default.
- W3204654219 cites W1548584275 @default.
- W3204654219 cites W1560892967 @default.
- W3204654219 cites W1602100985 @default.
- W3204654219 cites W1914851639 @default.
- W3204654219 cites W1976444920 @default.
- W3204654219 cites W1977818265 @default.
- W3204654219 cites W1983484216 @default.
- W3204654219 cites W1996050364 @default.
- W3204654219 cites W1997208476 @default.
- W3204654219 cites W1997416444 @default.
- W3204654219 cites W1999035751 @default.
- W3204654219 cites W2006774451 @default.
- W3204654219 cites W2008960002 @default.
- W3204654219 cites W2010579141 @default.
- W3204654219 cites W2010957046 @default.
- W3204654219 cites W2013556191 @default.
- W3204654219 cites W2015504883 @default.
- W3204654219 cites W2021115043 @default.
- W3204654219 cites W2023019116 @default.
- W3204654219 cites W2023471672 @default.
- W3204654219 cites W2031389689 @default.
- W3204654219 cites W2032077862 @default.
- W3204654219 cites W2040271965 @default.
- W3204654219 cites W2041544510 @default.
- W3204654219 cites W2042545521 @default.
- W3204654219 cites W2045180319 @default.
- W3204654219 cites W2046551442 @default.
- W3204654219 cites W2054736916 @default.
- W3204654219 cites W2058362425 @default.
- W3204654219 cites W2059571803 @default.
- W3204654219 cites W2061071534 @default.
- W3204654219 cites W2061755142 @default.
- W3204654219 cites W2062350961 @default.
- W3204654219 cites W2071041688 @default.
- W3204654219 cites W2073578030 @default.
- W3204654219 cites W2073807083 @default.
- W3204654219 cites W2078633109 @default.
- W3204654219 cites W2083272335 @default.
- W3204654219 cites W2093794516 @default.
- W3204654219 cites W2101328621 @default.
- W3204654219 cites W2118133237 @default.
- W3204654219 cites W2119394245 @default.
- W3204654219 cites W2122061305 @default.
- W3204654219 cites W2128256085 @default.
- W3204654219 cites W2128455103 @default.
- W3204654219 cites W2128627731 @default.
- W3204654219 cites W2130197051 @default.
- W3204654219 cites W2136909149 @default.
- W3204654219 cites W2142528162 @default.
- W3204654219 cites W2144353950 @default.
- W3204654219 cites W2146358032 @default.
- W3204654219 cites W2147263332 @default.
- W3204654219 cites W2149913162 @default.
- W3204654219 cites W2151689458 @default.
- W3204654219 cites W2151776178 @default.
- W3204654219 cites W2151948277 @default.
- W3204654219 cites W2153150595 @default.
- W3204654219 cites W2153389047 @default.
- W3204654219 cites W2169929180 @default.
- W3204654219 cites W2180071684 @default.
- W3204654219 cites W2274924551 @default.
- W3204654219 cites W2320001394 @default.
- W3204654219 cites W2324375795 @default.
- W3204654219 cites W2324841714 @default.
- W3204654219 cites W2337955270 @default.
- W3204654219 cites W2424801367 @default.
- W3204654219 cites W2466594727 @default.
- W3204654219 cites W2484862915 @default.
- W3204654219 cites W2496744775 @default.
- W3204654219 cites W2514448694 @default.
- W3204654219 cites W2552281563 @default.
- W3204654219 cites W2559233139 @default.
- W3204654219 cites W2562578755 @default.
- W3204654219 cites W2608971349 @default.
- W3204654219 cites W2609834329 @default.
- W3204654219 cites W2744859578 @default.
- W3204654219 cites W2746228454 @default.
- W3204654219 cites W2765767647 @default.
- W3204654219 cites W2782685575 @default.
- W3204654219 cites W2783981715 @default.
- W3204654219 cites W2797499614 @default.
- W3204654219 cites W2800172676 @default.