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• W3204657993 startingPage "118229" @default.
• W3204657993 abstract "Polychlorinated biphenyls (PCBs) are persistent organic pollutants in environments, and they can negatively affect aquatic animal health. After 7 days of PCBs exposure, the activities of catalase, phenoloxidase, and superoxide dismutase and the total hemocyte count in the haemolymph were significantly decreased and the reactive oxygen species (ROS) content and phagocytic rate of hemocytes were significantly increased in mud crab Scylla paramamosain. Additionally, serum lysozyme, glutathione, glutathione-S-transferase, and glutathione peroxidase activities were significantly down-regulated in mud crab after PCBs exposure. The survival rate of crab hemocytes significantly declined as the PCBs concentration increased, indicating that PCBs had a cytotoxic effect on hemocytes. Exposure to increasing concentrations of PCBs also increased the degree of DNA damage in crab hemocytes. After PCBs exposure, the expression levels of P53 and caspase-3 in hemocytes were significantly up-regulated, which suggests that apoptosis was occurring. The apoptosis rate of hemocytes was up-regulated as the PCBs concentration increased, indicating that apoptosis was induced by the PCBs-activated caspase-3 pathway. These data suggest that exposure to PCBs hampered the immune response of mud crabs, most likely by (1) inducing ROS, causing DNA damage, and reducing the viability of hemocytes, (2) reducing the activities of antioxidant enzymes, and (3) inducing phagocytosis and apoptosis of hemocytes. And the final result of PCBs-induced immunotoxicity to mud crabs is the reduced bacterial disease resistance and survival rate of crabs under Vibrio alginolyticus challenge." @default.
• W3204657993 created "2021-10-11" @default.
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• W3204657993 date "2021-12-01" @default.
• W3204657993 modified "2023-10-16" @default.
• W3204657993 title "Immunotoxicity of polychlorinated biphenyls (PCBs) to the marine crustacean species, Scylla paramamosain" @default.
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• W3204657993 doi "https://doi.org/10.1016/j.envpol.2021.118229" @default.
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• W3204657993 hasPublicationYear "2021" @default.
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