Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204659482> ?p ?o ?g. }
- W3204659482 endingPage "10839" @default.
- W3204659482 startingPage "10839" @default.
- W3204659482 abstract "Glucocorticoids are the final products of the neuroendocrine hypothalamic-pituitary-adrenal axis, and play an important role in the stress response to re-establish homeostasis when it is threatened, or perceived as threatened. These steroid hormones have pleiotropic actions through binding to their cognate receptor, the human glucocorticoid receptor, which functions as a ligand-bound transcription factor inducing or repressing the expression of a large number of target genes. To achieve homeostasis, glucocorticoid signaling should have an optimal effect on all tissues. Indeed, any inappropriate glucocorticoid effect in terms of quantity or quality has been associated with pathologic conditions, which are characterized by short-term or long-lasting detrimental effects. Two such conditions, the primary generalized glucocorticoid resistance and hypersensitivity syndromes, are discussed in this review article. Undoubtedly, the tremendous progress of structural, molecular, and cellular biology, in association with the continued progress of biotechnology, has led to a better and more in-depth understanding of these rare endocrinologic conditions, as well as more effective therapeutic management." @default.
- W3204659482 created "2021-10-11" @default.
- W3204659482 creator A5027573695 @default.
- W3204659482 creator A5075213795 @default.
- W3204659482 date "2021-10-07" @default.
- W3204659482 modified "2023-09-29" @default.
- W3204659482 title "Primary Generalized Glucocorticoid Resistance and Hypersensitivity Syndromes: A 2021 Update" @default.
- W3204659482 cites W1508804129 @default.
- W3204659482 cites W1775014724 @default.
- W3204659482 cites W1836013023 @default.
- W3204659482 cites W1959492836 @default.
- W3204659482 cites W1966453802 @default.
- W3204659482 cites W1968680063 @default.
- W3204659482 cites W1969747128 @default.
- W3204659482 cites W1974791065 @default.
- W3204659482 cites W1981742600 @default.
- W3204659482 cites W1989365606 @default.
- W3204659482 cites W1991727114 @default.
- W3204659482 cites W1995754480 @default.
- W3204659482 cites W2009432353 @default.
- W3204659482 cites W2010142538 @default.
- W3204659482 cites W2010184268 @default.
- W3204659482 cites W2015263374 @default.
- W3204659482 cites W2020896282 @default.
- W3204659482 cites W2021335702 @default.
- W3204659482 cites W2021404645 @default.
- W3204659482 cites W2021964084 @default.
- W3204659482 cites W2025646443 @default.
- W3204659482 cites W2029637415 @default.
- W3204659482 cites W2036845348 @default.
- W3204659482 cites W2038573597 @default.
- W3204659482 cites W2040214881 @default.
- W3204659482 cites W2044587574 @default.
- W3204659482 cites W2047490631 @default.
- W3204659482 cites W2056655687 @default.
- W3204659482 cites W2065890957 @default.
- W3204659482 cites W2076507733 @default.
- W3204659482 cites W2077716901 @default.
- W3204659482 cites W2082354784 @default.
- W3204659482 cites W2082853307 @default.
- W3204659482 cites W2083853317 @default.
- W3204659482 cites W2083938806 @default.
- W3204659482 cites W2085617928 @default.
- W3204659482 cites W2097525953 @default.
- W3204659482 cites W2101754579 @default.
- W3204659482 cites W2103331727 @default.
- W3204659482 cites W2106370522 @default.
- W3204659482 cites W2106470286 @default.
- W3204659482 cites W2111153065 @default.
- W3204659482 cites W2118442033 @default.
- W3204659482 cites W2121078836 @default.
- W3204659482 cites W2124848705 @default.
- W3204659482 cites W2127464622 @default.
- W3204659482 cites W2134266632 @default.
- W3204659482 cites W2137899652 @default.
- W3204659482 cites W2146636800 @default.
- W3204659482 cites W2152123169 @default.
- W3204659482 cites W2152833835 @default.
- W3204659482 cites W2155539407 @default.
- W3204659482 cites W2164108954 @default.
- W3204659482 cites W2164942621 @default.
- W3204659482 cites W2168894358 @default.
- W3204659482 cites W2221785436 @default.
- W3204659482 cites W2331176038 @default.
- W3204659482 cites W2331953902 @default.
- W3204659482 cites W2343055462 @default.
- W3204659482 cites W2407632512 @default.
- W3204659482 cites W2573516633 @default.
- W3204659482 cites W2606520198 @default.
- W3204659482 cites W2606919344 @default.
- W3204659482 cites W2744459261 @default.
- W3204659482 cites W2785991766 @default.
- W3204659482 cites W2800731591 @default.
- W3204659482 cites W2883166613 @default.
- W3204659482 cites W2886982145 @default.
- W3204659482 cites W2889289357 @default.
- W3204659482 cites W2902671349 @default.
- W3204659482 cites W2911829707 @default.
- W3204659482 cites W2937150174 @default.
- W3204659482 cites W2946292514 @default.
- W3204659482 cites W2949742345 @default.
- W3204659482 cites W2950063350 @default.
- W3204659482 cites W2964367526 @default.
- W3204659482 cites W2967027447 @default.
- W3204659482 cites W2983610013 @default.
- W3204659482 cites W2987000003 @default.
- W3204659482 cites W3003996692 @default.
- W3204659482 cites W3004999718 @default.
- W3204659482 cites W3006334961 @default.
- W3204659482 cites W3012871840 @default.
- W3204659482 cites W3024561096 @default.
- W3204659482 cites W3038383902 @default.
- W3204659482 cites W3092137466 @default.
- W3204659482 cites W3125598118 @default.
- W3204659482 cites W3140707757 @default.
- W3204659482 cites W3156706697 @default.
- W3204659482 cites W3170772438 @default.
- W3204659482 cites W3173562740 @default.