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- W3204667296 abstract "<h3>Introduction</h3> Stent under-expansion has been known to be associated with worse outcomes. We sought to define optical coherence tomography (OCT) assessed optimal stent expansion index (SEI) which associates with lower incidence of major adverse cardiac events (MACE) during follow-up. <h3>Methods</h3> We included 370 lesions who underwent PCI during 2012-2018 at five high volume European centers, with their final procedural results imaged using OCT. Stent expansion index (SEI) was calculated separately for both stent halves by dividing minimum stent area by the mean reference lumen area [(proximal reference area + distal reference area)/2]. (Figure 1, Panel A) Follow-up MACE was defined as a composite of all-cause death, myocardial infarction, stent thrombosis and target lesion revascularization. <h3>Results</h3> A total of 316 cases (370 lesions) were analysed. Minimal stent area (MSA) of the whole cohort was 6.02 (4.65, 7.93) mm<sup>2</sup>, while SEI was 0.79 (0.71, 0.86). During a median follow-up duration of 557 (326, 1,096) days, we recoded 47 (12.7%) incidences of MACE. Receiver operating characteristic (ROC) curve analysis identified 0.85 as SEI cut-off powered to predict MACE during follow-up (AUC= 0.60, sensitivity= 0.85, specificity= 0.34). (Figure 1, Panel B) MACE was observed in 38/249 (15.3%) of lesions with SEI<0.85 and in 9/121 (7.4%) of lesions with SEI≥0.85 (p=0.03). Adaptive Lasso regression identified SEI<0.85 (OR=4.76, 95% CI=1.70-13.30, p=0.0029) and coronary calcification at baseline (OR=2.70, 95% CI=1.11-6.58, p=0.0292) as independent predictors of MACE during follow-up. (Figure 1, Panel C). <h3>Conclusions</h3> The present study identified SEI≥0.85, associated with lower incidence of MACE as optimal cut-off in daily practice. Along with SEI of <0.85, coronary calcification was also found to be significantly associated with MACE during post-PCI follow-up." @default.
- W3204667296 created "2021-10-11" @default.
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- W3204667296 date "2021-10-01" @default.
- W3204667296 modified "2023-10-16" @default.
- W3204667296 title "8 Stent optimization using optical coherence tomography and its prognostic implications after percutaneous coronary intervention" @default.
- W3204667296 doi "https://doi.org/10.1136/heartjnl-2021-ics.8" @default.
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