Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204669066> ?p ?o ?g. }
- W3204669066 endingPage "22489" @default.
- W3204669066 startingPage "22474" @default.
- W3204669066 abstract "Melanoma causes the highest mortality rate among all skin cancers. However, the underlying molecular mechanisms leading to metastasis and poor prognosis in melanoma have not been fully elucidated. In this study, the differentially expressed genes (DEGs) related to metastasis in melanoma were screened out. The results of gene annotation was combined with The Cancer Genome Atlas (TCGA) database. The microRNA (miRNA) network that regulates key genes and their correlation with BRAFV600E was preliminarily analyzed. Cell and molecular biology experiments were conducted to verify the results of bioinformatics analysis. Results showed that the PI3K-Akt signaling pathway contained the key genes CDK2, CDK4, KIT, and Von Willebrand factor. Survival analysis showed that high expression of the four key genes significantly reduced the survival rate of patients with melanoma. Correlation analysis showed that BRAFV600E may regulate the expression of the four key genes, and a total of 240 miRNAs may regulate this expression. Experiments showed that the inactivation of key genes inhibits the proliferation, migration, and invasion of melanoma. In conclusion, the PI3K-Akt signaling pathway and the four key genes promoted the proliferation, migration, and invasion of melanoma, and related to poor prognosis of patients with melanoma." @default.
- W3204669066 created "2021-10-11" @default.
- W3204669066 creator A5006651636 @default.
- W3204669066 creator A5037015805 @default.
- W3204669066 creator A5061975741 @default.
- W3204669066 creator A5071981644 @default.
- W3204669066 date "2021-09-28" @default.
- W3204669066 modified "2023-09-27" @default.
- W3204669066 title "Identification of genes and pathways leading to metastasis and poor prognosis in melanoma" @default.
- W3204669066 cites W1763578156 @default.
- W3204669066 cites W1950829641 @default.
- W3204669066 cites W1971947883 @default.
- W3204669066 cites W1985139403 @default.
- W3204669066 cites W1985821753 @default.
- W3204669066 cites W1992109206 @default.
- W3204669066 cites W1992318779 @default.
- W3204669066 cites W2006262026 @default.
- W3204669066 cites W2008205044 @default.
- W3204669066 cites W2015583071 @default.
- W3204669066 cites W2016518678 @default.
- W3204669066 cites W2035618305 @default.
- W3204669066 cites W2039425268 @default.
- W3204669066 cites W2051400717 @default.
- W3204669066 cites W2058990434 @default.
- W3204669066 cites W2062406657 @default.
- W3204669066 cites W2063239613 @default.
- W3204669066 cites W2073947187 @default.
- W3204669066 cites W2086969829 @default.
- W3204669066 cites W2092992156 @default.
- W3204669066 cites W2099044540 @default.
- W3204669066 cites W2110838720 @default.
- W3204669066 cites W2126194784 @default.
- W3204669066 cites W2129679153 @default.
- W3204669066 cites W2146512944 @default.
- W3204669066 cites W2146875866 @default.
- W3204669066 cites W2148855188 @default.
- W3204669066 cites W2166262263 @default.
- W3204669066 cites W2254594392 @default.
- W3204669066 cites W2285196165 @default.
- W3204669066 cites W2347065665 @default.
- W3204669066 cites W2399166025 @default.
- W3204669066 cites W2506963569 @default.
- W3204669066 cites W2590266293 @default.
- W3204669066 cites W2604271042 @default.
- W3204669066 cites W2605233023 @default.
- W3204669066 cites W2747570594 @default.
- W3204669066 cites W2773203439 @default.
- W3204669066 cites W2783121990 @default.
- W3204669066 cites W2788573148 @default.
- W3204669066 cites W2790351808 @default.
- W3204669066 cites W2800512087 @default.
- W3204669066 cites W2892060206 @default.
- W3204669066 cites W2896937787 @default.
- W3204669066 cites W2902263717 @default.
- W3204669066 cites W2904157729 @default.
- W3204669066 cites W2904320752 @default.
- W3204669066 cites W2959920052 @default.
- W3204669066 cites W2969491369 @default.
- W3204669066 cites W2976758067 @default.
- W3204669066 cites W2996266550 @default.
- W3204669066 cites W3004493255 @default.
- W3204669066 cites W3010560689 @default.
- W3204669066 cites W3012778031 @default.
- W3204669066 cites W3019361809 @default.
- W3204669066 cites W3024751572 @default.
- W3204669066 cites W3091776144 @default.
- W3204669066 cites W393883301 @default.
- W3204669066 cites W4246941535 @default.
- W3204669066 cites W4254687493 @default.
- W3204669066 cites W4294214970 @default.
- W3204669066 doi "https://doi.org/10.18632/aging.203554" @default.
- W3204669066 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8507267" @default.
- W3204669066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34582363" @default.
- W3204669066 hasPublicationYear "2021" @default.
- W3204669066 type Work @default.
- W3204669066 sameAs 3204669066 @default.
- W3204669066 citedByCount "3" @default.
- W3204669066 countsByYear W32046690662022 @default.
- W3204669066 countsByYear W32046690662023 @default.
- W3204669066 crossrefType "journal-article" @default.
- W3204669066 hasAuthorship W3204669066A5006651636 @default.
- W3204669066 hasAuthorship W3204669066A5037015805 @default.
- W3204669066 hasAuthorship W3204669066A5061975741 @default.
- W3204669066 hasAuthorship W3204669066A5071981644 @default.
- W3204669066 hasBestOaLocation W32046690661 @default.
- W3204669066 hasConcept C104317684 @default.
- W3204669066 hasConcept C121608353 @default.
- W3204669066 hasConcept C145059251 @default.
- W3204669066 hasConcept C2777658100 @default.
- W3204669066 hasConcept C2779013556 @default.
- W3204669066 hasConcept C502942594 @default.
- W3204669066 hasConcept C54355233 @default.
- W3204669066 hasConcept C62478195 @default.
- W3204669066 hasConcept C75217442 @default.
- W3204669066 hasConcept C86554907 @default.
- W3204669066 hasConcept C86803240 @default.
- W3204669066 hasConceptScore W3204669066C104317684 @default.
- W3204669066 hasConceptScore W3204669066C121608353 @default.