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- W3204671004 abstract "In chronic hepatitis B and C virus infections persistently elevated antigen levels drive CD8+ T cells toward a peculiar differentiation state known as T cell exhaustion, which poses crucial constraints to antiviral immunity. Available evidence indicates that T cell exhaustion is associated with a series of metabolic and signaling deregulations and with a very peculiar epigenetic status which all together lead to reduced effector functions. A clear mechanistic network explaining how intracellular metabolic derangements, transcriptional and signaling alterations so far described are interconnected in a comprehensive and unified view of the T cell exhaustion differentiation profile is still lacking. Addressing this issue is of key importance for the development of innovative strategies to boost host immunity in order to achieve viral clearance. This review will discuss the current knowledge in HBV and HCV infections, addressing how innate immunity, metabolic derangements, extensive stress responses and altered epigenetic programs may be targeted to restore functionality and responsiveness of virus-specific CD8 T cells in the context of chronic virus infections." @default.
- W3204671004 created "2021-10-11" @default.
- W3204671004 creator A5028847995 @default.
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- W3204671004 date "2021-09-28" @default.
- W3204671004 modified "2023-10-16" @default.
- W3204671004 title "Unraveling the Multifaceted Nature of CD8 T Cell Exhaustion Provides the Molecular Basis for Therapeutic T Cell Reconstitution in Chronic Hepatitis B and C" @default.
- W3204671004 cites W1617786219 @default.
- W3204671004 cites W1623473717 @default.
- W3204671004 cites W171019159 @default.
- W3204671004 cites W1890766043 @default.
- W3204671004 cites W1907974286 @default.
- W3204671004 cites W1910012553 @default.
- W3204671004 cites W1944753949 @default.
- W3204671004 cites W1957522192 @default.
- W3204671004 cites W1966644185 @default.
- W3204671004 cites W1975566288 @default.
- W3204671004 cites W1976355501 @default.
- W3204671004 cites W1976682189 @default.
- W3204671004 cites W1978918363 @default.
- W3204671004 cites W1983251878 @default.
- W3204671004 cites W1985293294 @default.
- W3204671004 cites W1987337968 @default.
- W3204671004 cites W1989674299 @default.
- W3204671004 cites W1990555844 @default.
- W3204671004 cites W1992581811 @default.
- W3204671004 cites W1993686673 @default.
- W3204671004 cites W1999770898 @default.
- W3204671004 cites W2011020699 @default.
- W3204671004 cites W2012025617 @default.
- W3204671004 cites W2015035059 @default.
- W3204671004 cites W2018599533 @default.
- W3204671004 cites W2018775174 @default.
- W3204671004 cites W2018792466 @default.
- W3204671004 cites W2019135290 @default.
- W3204671004 cites W2019799131 @default.
- W3204671004 cites W2021764678 @default.
- W3204671004 cites W2024876727 @default.
- W3204671004 cites W2025714915 @default.
- W3204671004 cites W2027555120 @default.
- W3204671004 cites W2030150321 @default.
- W3204671004 cites W2030342863 @default.
- W3204671004 cites W2033239466 @default.
- W3204671004 cites W2033748513 @default.
- W3204671004 cites W2037610638 @default.
- W3204671004 cites W2037856116 @default.
- W3204671004 cites W2046828081 @default.
- W3204671004 cites W2046959528 @default.
- W3204671004 cites W2053029118 @default.
- W3204671004 cites W2060608189 @default.
- W3204671004 cites W2077116159 @default.
- W3204671004 cites W2079999658 @default.
- W3204671004 cites W2082959814 @default.
- W3204671004 cites W2084377803 @default.
- W3204671004 cites W2084885369 @default.
- W3204671004 cites W2089574530 @default.
- W3204671004 cites W2089760439 @default.
- W3204671004 cites W2090407934 @default.
- W3204671004 cites W2091172564 @default.
- W3204671004 cites W2096077301 @default.
- W3204671004 cites W2096083625 @default.
- W3204671004 cites W2097855813 @default.
- W3204671004 cites W2104966044 @default.
- W3204671004 cites W2105697998 @default.
- W3204671004 cites W2116676186 @default.
- W3204671004 cites W2124898423 @default.
- W3204671004 cites W2127483170 @default.
- W3204671004 cites W2132205831 @default.
- W3204671004 cites W2135144687 @default.
- W3204671004 cites W2144575277 @default.
- W3204671004 cites W2145200068 @default.
- W3204671004 cites W2150551502 @default.
- W3204671004 cites W2152095262 @default.
- W3204671004 cites W2163001100 @default.
- W3204671004 cites W2164164239 @default.
- W3204671004 cites W2166840738 @default.
- W3204671004 cites W2167869412 @default.
- W3204671004 cites W2200678142 @default.
- W3204671004 cites W2225639217 @default.
- W3204671004 cites W2346441562 @default.
- W3204671004 cites W2406555542 @default.
- W3204671004 cites W2424031828 @default.
- W3204671004 cites W2470982690 @default.
- W3204671004 cites W2478467838 @default.
- W3204671004 cites W2481773770 @default.
- W3204671004 cites W2506616866 @default.
- W3204671004 cites W2513922839 @default.
- W3204671004 cites W2521733471 @default.
- W3204671004 cites W2523989131 @default.
- W3204671004 cites W2527179423 @default.