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• W3204671235 endingPage "4834" @default.
• W3204671235 startingPage "4834" @default.
• W3204671235 abstract "Pancreatic ductal adenocarcinoma (PDAC) is a type of cancer that is strongly associated with poor prognosis and short median survival times. In stark contrast to the progress seen in other cancer types in recent decades, discoveries of new treatments in PDAC have been few and far between and there has been little improvement in overall survival (OS). The difficulty in treating this disease is multifactorial, contributed to by late presentation, difficult access to primary tumour sites, an 'immunologically cold' phenotype, and a strong tendency of recurrence likely driven by cancer stem cell (CSC) populations. Furthermore, apparently contrasting roles of tumour components (such as fibrotic stroma) and intracellular pathways (such as autophagy and TGFβ) have made it difficult to distinguish beneficial from detrimental drug targets. Despite this, progress has been made in the field, including the determination of mFOLFIRINOX as the standard-of-care adjuvant therapy and the discovery of KRASG12C mutant inhibitors. Moreover, new research, as outlined in this review, has highlighted promising new approaches including the targeting of the tumour microenvironment, enhancement of immunotherapies, epigenetic modulation, and destruction of CSCs." @default.
• W3204671235 created "2021-10-11" @default.
• W3204671235 creator A5000749022 @default.
• W3204671235 creator A5083991151 @default.
• W3204671235 date "2021-09-28" @default.
• W3204671235 modified "2023-09-27" @default.
• W3204671235 title "Mechanisms of Cancer Cell Death: Therapeutic Implications for Pancreatic Ductal Adenocarcinoma" @default.
• W3204671235 cites W1497915798 @default.
• W3204671235 cites W1539621112 @default.
• W3204671235 cites W1704193871 @default.
• W3204671235 cites W1898150109 @default.
• W3204671235 cites W1939365747 @default.
• W3204671235 cites W1940824108 @default.
• W3204671235 cites W1963878229 @default.
• W3204671235 cites W1972149587 @default.
• W3204671235 cites W1972625598 @default.
• W3204671235 cites W1984564310 @default.
• W3204671235 cites W1988783376 @default.
• W3204671235 cites W1996912024 @default.
• W3204671235 cites W2009886857 @default.
• W3204671235 cites W2011649365 @default.
• W3204671235 cites W2019264784 @default.
• W3204671235 cites W2025915231 @default.
• W3204671235 cites W2029443168 @default.
• W3204671235 cites W2031505107 @default.
• W3204671235 cites W2044363258 @default.
• W3204671235 cites W2044423100 @default.
• W3204671235 cites W2055091294 @default.
• W3204671235 cites W2059641782 @default.
• W3204671235 cites W2061197983 @default.
• W3204671235 cites W2067851902 @default.
• W3204671235 cites W2083761512 @default.
• W3204671235 cites W2092100136 @default.
• W3204671235 cites W2095569714 @default.
• W3204671235 cites W2102690338 @default.
• W3204671235 cites W2107216996 @default.
• W3204671235 cites W2116495352 @default.
• W3204671235 cites W2118263555 @default.
• W3204671235 cites W2118448242 @default.
• W3204671235 cites W2131170195 @default.
• W3204671235 cites W2132445818 @default.
• W3204671235 cites W2137967850 @default.
• W3204671235 cites W2146177965 @default.
• W3204671235 cites W2150048477 @default.
• W3204671235 cites W2151253787 @default.
• W3204671235 cites W2152061559 @default.
• W3204671235 cites W2154790710 @default.
• W3204671235 cites W2157223841 @default.
• W3204671235 cites W2158134441 @default.
• W3204671235 cites W2163032348 @default.
• W3204671235 cites W2165480504 @default.
• W3204671235 cites W2261461400 @default.
• W3204671235 cites W2267406903 @default.
• W3204671235 cites W2285093314 @default.
• W3204671235 cites W2293645537 @default.
• W3204671235 cites W2336583997 @default.
• W3204671235 cites W2416038770 @default.
• W3204671235 cites W2469223980 @default.
• W3204671235 cites W2498212369 @default.
• W3204671235 cites W2514594194 @default.
• W3204671235 cites W2562790498 @default.
• W3204671235 cites W2568414132 @default.
• W3204671235 cites W2593764076 @default.
• W3204671235 cites W2594738913 @default.
• W3204671235 cites W2596919450 @default.
• W3204671235 cites W2597062310 @default.
• W3204671235 cites W2606436364 @default.
• W3204671235 cites W2612422316 @default.
• W3204671235 cites W2746266812 @default.
• W3204671235 cites W2748710555 @default.
• W3204671235 cites W2771729549 @default.
• W3204671235 cites W2772923107 @default.
• W3204671235 cites W2773849850 @default.
• W3204671235 cites W2783164910 @default.
• W3204671235 cites W2785187242 @default.
• W3204671235 cites W2790254562 @default.
• W3204671235 cites W2791027362 @default.
• W3204671235 cites W2792595617 @default.
• W3204671235 cites W2794160747 @default.
• W3204671235 cites W2800976990 @default.
• W3204671235 cites W2803724995 @default.
• W3204671235 cites W2806944854 @default.
• W3204671235 cites W2807122763 @default.
• W3204671235 cites W2835158150 @default.
• W3204671235 cites W2885492789 @default.
• W3204671235 cites W2886595753 @default.
• W3204671235 cites W2891918458 @default.
• W3204671235 cites W2891989464 @default.
• W3204671235 cites W2896417295 @default.
• W3204671235 cites W2896652675 @default.
• W3204671235 cites W2897660975 @default.
• W3204671235 cites W2900349978 @default.
• W3204671235 cites W2903623792 @default.
• W3204671235 cites W2909786746 @default.
• W3204671235 cites W2917919815 @default.
• W3204671235 cites W2919645054 @default.
• W3204671235 cites W2921824094 @default.
• W3204671235 cites W2937076225 @default.

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