FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204674641> ?p ?o ?g. }

• W3204674641 abstract "Abstract Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2)/ coronavirus disease 2019 (COVID-19) infection is the leading cause of respiratory tract infection associated mortality worldwide. The aim of the current investigation was to identify the differentially expressed genes (DEGs) and enriched pathways in COVID-19 infection and its associated complications by bioinformatics analysis, and to provide potential targets for diagnosis and treatment. Valid next-generation sequencing (NGS) data of 93 COVID 19 samples and 100 non COVID 19 samples (GSE156063) were obtained from the Gene Expression Omnibus database. Gene ontology (GO) and REACTOME pathway enrichment analysis was conducted to identify the biological role of DEGs. In addition, a protein-protein interaction network, modules, miRNA-hub gene regulatory network, TF-hub gene regulatory network and receiver operating characteristic curve (ROC) analysis were used to identify the key genes. A total of 738 DEGs were identified, including 415 up regulated genes and 323 down regulated genes. Most of the DEGs were significantly enriched in immune system process, cell communication, immune system and signaling by NTRK1 (TRKA). Through PPI, modules, miRNA-hub gene regulatory network, TF-hub gene regulatory network analysis, ESR1, UBD, FYN, STAT1, ISG15, EGR1, ARRB2, UBE2D1, PRKDC and FOS were selected as hub genes, which were expressed in COVID-19 samples relative to those in non COVID-19 samples, respectively. Among them, ESR1, UBD, FYN, STAT1, ISG15, EGR1, ARRB2, UBE2D1, PRKDC and FOS were suggested to be diagonstic factors for COVID-19. The findings from this bioinformatics analysis study identified molecular mechanisms and the key hub genes that might contribute to COVID-19 infection and its associated complications." @default.
• W3204674641 created "2021-10-11" @default.
• W3204674641 creator A5007122462 @default.
• W3204674641 creator A5059976576 @default.
• W3204674641 date "2021-09-25" @default.
• W3204674641 modified "2023-09-26" @default.
• W3204674641 title "Screening key genes and signaling pathways in COVID-19 infection and its associated complications by integrated bioinformatics analysis" @default.
• W3204674641 cites W1493008883 @default.
• W3204674641 cites W1495362663 @default.
• W3204674641 cites W1525994023 @default.
• W3204674641 cites W1536101230 @default.
• W3204674641 cites W1547908284 @default.
• W3204674641 cites W1835994994 @default.
• W3204674641 cites W1850846169 @default.
• W3204674641 cites W1855616383 @default.
• W3204674641 cites W189857981 @default.
• W3204674641 cites W1900314770 @default.
• W3204674641 cites W1911106125 @default.
• W3204674641 cites W1934008305 @default.
• W3204674641 cites W1964536962 @default.
• W3204674641 cites W1964755688 @default.
• W3204674641 cites W1965734538 @default.
• W3204674641 cites W1969040512 @default.
• W3204674641 cites W1970043144 @default.
• W3204674641 cites W1970077536 @default.
• W3204674641 cites W1971604855 @default.
• W3204674641 cites W1972958690 @default.
• W3204674641 cites W1981035635 @default.
• W3204674641 cites W1984836036 @default.
• W3204674641 cites W1987840126 @default.
• W3204674641 cites W1991719590 @default.
• W3204674641 cites W1992508539 @default.
• W3204674641 cites W1995683190 @default.
• W3204674641 cites W1997292668 @default.
• W3204674641 cites W1998460673 @default.
• W3204674641 cites W1999178719 @default.
• W3204674641 cites W1999492084 @default.
• W3204674641 cites W2001216873 @default.
• W3204674641 cites W2003605610 @default.
• W3204674641 cites W2006617902 @default.
• W3204674641 cites W2006684649 @default.
• W3204674641 cites W2009143592 @default.
• W3204674641 cites W2016111105 @default.
• W3204674641 cites W2018576492 @default.
• W3204674641 cites W2019811642 @default.
• W3204674641 cites W2020233018 @default.
• W3204674641 cites W2022955753 @default.
• W3204674641 cites W2027638825 @default.
• W3204674641 cites W2028072333 @default.
• W3204674641 cites W2031094596 @default.
• W3204674641 cites W2031205327 @default.
• W3204674641 cites W2031254105 @default.
• W3204674641 cites W2035100890 @default.
• W3204674641 cites W2036168232 @default.
• W3204674641 cites W2040633094 @default.
• W3204674641 cites W2041083435 @default.
• W3204674641 cites W2042447013 @default.
• W3204674641 cites W2043296492 @default.
• W3204674641 cites W2043638916 @default.
• W3204674641 cites W2043681485 @default.
• W3204674641 cites W2044037509 @default.
• W3204674641 cites W2045430076 @default.
• W3204674641 cites W2046889140 @default.
• W3204674641 cites W2048651746 @default.
• W3204674641 cites W2049832313 @default.
• W3204674641 cites W2050034843 @default.
• W3204674641 cites W2051314090 @default.
• W3204674641 cites W2057562851 @default.
• W3204674641 cites W2059569484 @default.
• W3204674641 cites W2059787313 @default.
• W3204674641 cites W2061262615 @default.
• W3204674641 cites W2061801570 @default.
• W3204674641 cites W2064397364 @default.
• W3204674641 cites W2064790354 @default.
• W3204674641 cites W2066529599 @default.
• W3204674641 cites W2067036337 @default.
• W3204674641 cites W2068513765 @default.
• W3204674641 cites W2071874620 @default.
• W3204674641 cites W2072450611 @default.
• W3204674641 cites W2072471702 @default.
• W3204674641 cites W2073191781 @default.
• W3204674641 cites W2074706032 @default.
• W3204674641 cites W2079039502 @default.
• W3204674641 cites W2080453657 @default.
• W3204674641 cites W2082813091 @default.
• W3204674641 cites W2084530852 @default.
• W3204674641 cites W2084561266 @default.
• W3204674641 cites W2084981187 @default.
• W3204674641 cites W2087801463 @default.
• W3204674641 cites W2091328820 @default.
• W3204674641 cites W2093596177 @default.
• W3204674641 cites W2094051620 @default.
• W3204674641 cites W2095501545 @default.
• W3204674641 cites W2098474645 @default.
• W3204674641 cites W2105734096 @default.
• W3204674641 cites W2106777868 @default.
• W3204674641 cites W2107556163 @default.
• W3204674641 cites W2108819945 @default.
• W3204674641 cites W2109388699 @default.
• W3204674641 cites W2110169118 @default.

• next