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• W3204675064 abstract "Abstract Numerous brain regions have been identified as contributing to addiction-like behaviors, but unclear is the way in which these brain regions as a whole lead to addiction. The search for a final common brain pathway that is involved in addiction remains elusive. To address this question, we used male C57BL/6J mice and performed single-cell whole-brain imaging of neural activity during withdrawal from cocaine, methamphetamine, and nicotine. We used hierarchical clustering and graph theory to identify similarities and differences in brain functional architecture. Although methamphetamine and cocaine shared some network similarities, the main common neuroadaptation between these psychostimulant drugs was a dramatic decrease in modularity, with a shift from a cortical- to subcortical-driven network, including a decrease in total hub brain regions. These results demonstrate that psychostimulant withdrawal produces the drug-dependent remodeling of functional architecture of the brain and suggest that the decreased modularity of brain functional networks and not a specific set of brain regions may represent the final common pathway that leads to addiction. Significance Statement A key aspect of treating drug abuse is understanding similarities and differences of how drugs of abuse affect the brain. In the present study we examined how the brain is altered during withdrawal from psychostimulants. We found that each drug produced a unique pattern of activity in the brain, but that brains in withdrawal from cocaine and methamphetamine shared similar features. Interestingly, we found the major common link between withdrawal from all psychostimulants, when compared to controls, was a shift in the broad organization of the brain in the form of reduced modularity. Reduced modularity has been shown in several brain disorders, including traumatic brain injury, and dementia, and may be the common link between drugs of abuse." @default.
• W3204675064 created "2021-10-11" @default.
• W3204675064 creator A5016969995 @default.
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• W3204675064 creator A5080399787 @default.
• W3204675064 creator A5084558282 @default.
• W3204675064 date "2019-08-22" @default.
• W3204675064 modified "2023-09-23" @default.
• W3204675064 title "Characterization of the brain functional architecture of psychostimulant withdrawal using single-cell whole brain imaging" @default.
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• W3204675064 doi "https://doi.org/10.1101/743799" @default.
• W3204675064 hasPublicationYear "2019" @default.
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