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• W3204676616 endingPage "4779" @default.
• W3204676616 startingPage "4779" @default.
• W3204676616 abstract "Breast cancer remains one of the most important health problems worldwide. The family of steroid receptors (SRs), which comprise estrogen (ER), progesterone (PR), androgen (AR), glucocorticoid (GR) and mineralocorticoid (MR) receptors, along with a receptor for a secosteroid-vitamin D, play a crucial role in the pathogenesis of the disease. They function predominantly as nuclear receptors to regulate gene expression, however, their full spectrum of action reaches far beyond this basic mechanism. SRs are involved in a vast variety of interactions with other proteins, including extensive crosstalk with each other. How they affect the biology of a breast cell depends on such factors as post-translational modifications, expression of coregulators, or which SR isoform is predominantly synthesized in a given cellular context. Although ER has been successfully utilized as a breast cancer therapy target for years, research on therapeutic application of other SRs is still ongoing. Designing effective hormone therapies requires thorough understanding of the molecular function of the SRs. Over the past decades, huge amount of data was obtained in multiple studies exploring this field, therefore in this review we attempt to summarize the current knowledge in a comprehensive way." @default.
• W3204676616 created "2021-10-11" @default.
• W3204676616 creator A5024499950 @default.
• W3204676616 creator A5033160003 @default.
• W3204676616 creator A5063395947 @default.
• W3204676616 creator A5083978970 @default.
• W3204676616 date "2021-09-24" @default.
• W3204676616 modified "2023-10-06" @default.
• W3204676616 title "Steroid Receptors in Breast Cancer: Understanding of Molecular Function as a Basis for Effective Therapy Development" @default.
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