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- W3204681112 abstract "Autoimmune hepatitis (AIH) is a chronic inflammatory disorder characterized by hypergammaglobulinemia, presence of serum autoantibodies and histological features of interface hepatitis. AIH therapeutic management still relies on the administration of corticosteroids, azathioprine and other immunosuppressants like calcineurin inhibitors and mycophenolate mofetil. Withdrawal of immunosuppression often results in disease relapse, and, in some cases, therapy is ineffective or associated with serious side effects. Understanding the mechanisms underlying AIH pathogenesis is therefore of paramount importance to develop more effective and well tolerated agents capable of restoring immunotolerance to liver autoantigens. Imbalance between effector and regulatory cells permits liver damage perpetuation and progression in AIH. Impaired expression and regulation of CD39, an ectoenzyme key to immunotolerance maintenance, have been reported in Tregs and effector Th17-cells derived from AIH patients. Interference with these altered immunoregulatory pathways may open new therapeutic avenues that, in addition to limiting aberrant inflammatory responses, would also reconstitute immune homeostasis. In this review, we highlight the most recent findings in AIH immunopathogenesis and discuss how these could inform and direct the development of novel therapeutic tools." @default.
- W3204681112 created "2021-10-11" @default.
- W3204681112 creator A5003504779 @default.
- W3204681112 creator A5046370886 @default.
- W3204681112 creator A5047109448 @default.
- W3204681112 creator A5055337229 @default.
- W3204681112 creator A5090728786 @default.
- W3204681112 date "2021-09-28" @default.
- W3204681112 modified "2023-10-10" @default.
- W3204681112 title "Dysfunctional Immune Regulation in Autoimmune Hepatitis: From Pathogenesis to Novel Therapies" @default.
- W3204681112 cites W1506816544 @default.
- W3204681112 cites W1518082296 @default.
- W3204681112 cites W1530782041 @default.
- W3204681112 cites W1585589080 @default.
- W3204681112 cites W1608307860 @default.
- W3204681112 cites W1914199395 @default.
- W3204681112 cites W1927327477 @default.
- W3204681112 cites W1940126516 @default.
- W3204681112 cites W1957184790 @default.
- W3204681112 cites W1964062013 @default.
- W3204681112 cites W1966490902 @default.
- W3204681112 cites W1966919402 @default.
- W3204681112 cites W1970034835 @default.
- W3204681112 cites W1971320064 @default.
- W3204681112 cites W1971668390 @default.
- W3204681112 cites W1977743910 @default.
- W3204681112 cites W1978949756 @default.
- W3204681112 cites W1980921578 @default.
- W3204681112 cites W1982288970 @default.
- W3204681112 cites W1986455032 @default.
- W3204681112 cites W1987144168 @default.
- W3204681112 cites W1988238713 @default.
- W3204681112 cites W1994160001 @default.
- W3204681112 cites W1997982558 @default.
- W3204681112 cites W1998949806 @default.
- W3204681112 cites W2000959749 @default.
- W3204681112 cites W2001123056 @default.
- W3204681112 cites W2004522121 @default.
- W3204681112 cites W2006454795 @default.
- W3204681112 cites W2008811593 @default.
- W3204681112 cites W2009009216 @default.
- W3204681112 cites W2009415077 @default.
- W3204681112 cites W2012090583 @default.
- W3204681112 cites W2017729523 @default.
- W3204681112 cites W2021234462 @default.
- W3204681112 cites W2022552699 @default.
- W3204681112 cites W2024490058 @default.
- W3204681112 cites W2026784146 @default.
- W3204681112 cites W2029733235 @default.
- W3204681112 cites W2030973449 @default.
- W3204681112 cites W2034288342 @default.
- W3204681112 cites W2042844150 @default.
- W3204681112 cites W2043474597 @default.
- W3204681112 cites W2052074405 @default.
- W3204681112 cites W2060172645 @default.
- W3204681112 cites W2065938775 @default.
- W3204681112 cites W2066751213 @default.
- W3204681112 cites W2068373868 @default.
- W3204681112 cites W2071553791 @default.
- W3204681112 cites W2076839204 @default.
- W3204681112 cites W2079439641 @default.
- W3204681112 cites W2083826829 @default.
- W3204681112 cites W2086809028 @default.
- W3204681112 cites W2090185072 @default.
- W3204681112 cites W2092696659 @default.
- W3204681112 cites W2095937258 @default.
- W3204681112 cites W2098858453 @default.
- W3204681112 cites W2099766343 @default.
- W3204681112 cites W2100474263 @default.
- W3204681112 cites W2114097867 @default.
- W3204681112 cites W2118202213 @default.
- W3204681112 cites W2118268169 @default.
- W3204681112 cites W2124621398 @default.
- W3204681112 cites W2126072190 @default.
- W3204681112 cites W2128221678 @default.
- W3204681112 cites W2128802519 @default.
- W3204681112 cites W2132205159 @default.
- W3204681112 cites W2134122465 @default.
- W3204681112 cites W2137212819 @default.
- W3204681112 cites W2138105454 @default.
- W3204681112 cites W2140038579 @default.
- W3204681112 cites W2149742106 @default.
- W3204681112 cites W2150747144 @default.
- W3204681112 cites W2151434633 @default.
- W3204681112 cites W2152406167 @default.
- W3204681112 cites W2158200061 @default.
- W3204681112 cites W2159843982 @default.
- W3204681112 cites W2159954692 @default.
- W3204681112 cites W2160126419 @default.
- W3204681112 cites W2162768252 @default.
- W3204681112 cites W2166438464 @default.
- W3204681112 cites W2170705556 @default.
- W3204681112 cites W2316067769 @default.
- W3204681112 cites W2318366705 @default.
- W3204681112 cites W2339748828 @default.
- W3204681112 cites W2395579671 @default.
- W3204681112 cites W2426297731 @default.
- W3204681112 cites W2528859136 @default.
- W3204681112 cites W2577105811 @default.
- W3204681112 cites W2587006481 @default.