FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204685435> ?p ?o ?g. }

• W3204685435 endingPage "554" @default.
• W3204685435 startingPage "554" @default.
• W3204685435 abstract "Marine macroalgae are efficient producers of sulfated polysaccharides. The algal sulfated polysaccharides possess diverse bioactivities and peculiar chemical structures, and represent a great potential source to be explored. In the present study, a heparinoid-active sulfated polysaccharide was isolated from the green alga Cladophora oligoclada. Results of chemical and spectroscopic analyses indicated that the sulfated polysaccharide was composed of →6)-β-d-Galp-(1→, β-d-Galp-(1→, →6)-α-d-Glcp-(1→ and →3)-β-d-Galp-(1→ units with sulfate esters at C-2/C-4 of →6)-β-d-Galp-(1→, C-6 of →3)-β-d-Galp-(1→ and C-3 of →6)-α-d-Glcp-(1→ units. The branches consisting of β-d-Galp-(1→ and →6)-β-d-Galp-(1→ units were located in C-3 of →6)-β-d-Galp-(1→ units. The sulfated polysaccharide exhibited potent anticoagulant activity in vitro and in vivo as evaluated by activated partial thromboplastin time (APTT), thrombin time, and the fibrinogen level. For the APTT, the signal for clotting time was more than 200 s at 100 μg/mL in vitro and at 15 mg/kg in vivo. The obvious thrombolytic activity of the sulfated polysaccharide in vitro was also found. The mechanism analysis of anticoagulant action demonstrated that the sulfated polysaccharide significantly inhibited the activities of all intrinsic coagulation factors, which were less than 1.0% at 50 μg/mL, but selectively inhibited common coagulation factors. Furthermore, the sulfated polysaccharide strongly stimulated the inhibition of thrombin by potentiating antithrombin-III (AT-III) or heparin cofactor-II, and it also largely promoted the inhibition of factor Xa mediated by AT-III. These results revealed that the sulfated polysaccharide from C. oligoclada had potential to become an anticoagulant agent for prevention and therapy of thrombotic diseases." @default.
• W3204685435 created "2021-10-11" @default.
• W3204685435 creator A5003590800 @default.
• W3204685435 creator A5005890634 @default.
• W3204685435 creator A5028516523 @default.
• W3204685435 creator A5029250577 @default.
• W3204685435 creator A5071136049 @default.
• W3204685435 creator A5073216396 @default.
• W3204685435 creator A5082579987 @default.
• W3204685435 date "2021-09-29" @default.
• W3204685435 modified "2023-10-15" @default.
• W3204685435 title "Chemical Structure and Anticoagulant Property of a Novel Sulfated Polysaccharide from the Green Alga Cladophora oligoclada" @default.
• W3204685435 cites W1902995545 @default.
• W3204685435 cites W1959659843 @default.
• W3204685435 cites W1968834637 @default.
• W3204685435 cites W1970445147 @default.
• W3204685435 cites W1971434385 @default.
• W3204685435 cites W1973469796 @default.
• W3204685435 cites W1981510555 @default.
• W3204685435 cites W1987999118 @default.
• W3204685435 cites W1989519809 @default.
• W3204685435 cites W1994340802 @default.
• W3204685435 cites W1999652145 @default.
• W3204685435 cites W2021800696 @default.
• W3204685435 cites W2024791658 @default.
• W3204685435 cites W2025801569 @default.
• W3204685435 cites W2032690069 @default.
• W3204685435 cites W2037549569 @default.
• W3204685435 cites W2038946558 @default.
• W3204685435 cites W2050877942 @default.
• W3204685435 cites W2068314090 @default.
• W3204685435 cites W2080127961 @default.
• W3204685435 cites W2083671584 @default.
• W3204685435 cites W2084153421 @default.
• W3204685435 cites W2099749140 @default.
• W3204685435 cites W2111454395 @default.
• W3204685435 cites W2133080983 @default.
• W3204685435 cites W2154634442 @default.
• W3204685435 cites W2211881415 @default.
• W3204685435 cites W2269711959 @default.
• W3204685435 cites W2313028407 @default.
• W3204685435 cites W2340630159 @default.
• W3204685435 cites W2496473539 @default.
• W3204685435 cites W2526695847 @default.
• W3204685435 cites W2528514175 @default.
• W3204685435 cites W2560730412 @default.
• W3204685435 cites W2590746963 @default.
• W3204685435 cites W2625817708 @default.
• W3204685435 cites W2802732421 @default.
• W3204685435 cites W2891772158 @default.
• W3204685435 cites W2901968410 @default.
• W3204685435 cites W2903880242 @default.
• W3204685435 cites W2935197778 @default.
• W3204685435 cites W2940452299 @default.
• W3204685435 cites W2946706542 @default.
• W3204685435 cites W3026787770 @default.
• W3204685435 cites W3026919861 @default.
• W3204685435 cites W3034550285 @default.
• W3204685435 cites W3073655622 @default.
• W3204685435 cites W3090507028 @default.
• W3204685435 cites W3144109163 @default.
• W3204685435 cites W4293247451 @default.
• W3204685435 doi "https://doi.org/10.3390/md19100554" @default.
• W3204685435 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8540071" @default.
• W3204685435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34677453" @default.
• W3204685435 hasPublicationYear "2021" @default.
• W3204685435 type Work @default.
• W3204685435 sameAs 3204685435 @default.
• W3204685435 citedByCount "5" @default.
• W3204685435 countsByYear W32046854352022 @default.
• W3204685435 countsByYear W32046854352023 @default.
• W3204685435 crossrefType "journal-article" @default.
• W3204685435 hasAuthorship W3204685435A5003590800 @default.
• W3204685435 hasAuthorship W3204685435A5005890634 @default.
• W3204685435 hasAuthorship W3204685435A5028516523 @default.
• W3204685435 hasAuthorship W3204685435A5029250577 @default.
• W3204685435 hasAuthorship W3204685435A5071136049 @default.
• W3204685435 hasAuthorship W3204685435A5073216396 @default.
• W3204685435 hasAuthorship W3204685435A5082579987 @default.
• W3204685435 hasBestOaLocation W32046854351 @default.
• W3204685435 hasConcept C100817775 @default.
• W3204685435 hasConcept C118552586 @default.
• W3204685435 hasConcept C150903083 @default.
• W3204685435 hasConcept C153074725 @default.
• W3204685435 hasConcept C155138218 @default.
• W3204685435 hasConcept C185592680 @default.
• W3204685435 hasConcept C202751555 @default.
• W3204685435 hasConcept C203014093 @default.
• W3204685435 hasConcept C207001950 @default.
• W3204685435 hasConcept C2777292125 @default.
• W3204685435 hasConcept C2777557582 @default.
• W3204685435 hasConcept C2778162025 @default.
• W3204685435 hasConcept C2778261982 @default.
• W3204685435 hasConcept C2778382381 @default.
• W3204685435 hasConcept C2779026020 @default.
• W3204685435 hasConcept C2779863229 @default.
• W3204685435 hasConcept C2780077467 @default.
• W3204685435 hasConcept C55493867 @default.

• next