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- W3204686483 abstract "Abstract Background Care management of Parkinson’s disease (PD) patients currently remains symptomatic, especially because diagnosis relying on the expression of the cardinal motor symptoms is made too late. Detecting PD earlier therefore represents a key step for developing therapies able to delay or slow down its progression. Methods We investigated metabolic markers in three different animal models of PD, mimicking different phases of the disease assessed by behavioral and histological evaluation, and in 2 cohorts of de novo PD patients (n = 95). Serum and brain tissue samples were analyzed by nuclear magnetic resonance spectroscopy and data submitted to advanced multivariate statistics. Results Our translational strategy reveals common metabolic dysregulations in serum of the different animal models and PD patients. Some of them were mirrored in the tissue samples, possibly reflecting pathophysiological mechanisms associated with PD development. Interestingly, some metabolic dysregulations appeared before motor symptom emergence, and could represent early biomarkers of PD. Finally, we built a composite biomarker with a combination of 6 metabolites. This biomarker discriminated animals mimicking PD from controls, even from the first, non-motor signs and very interestingly, also discriminated PD patients from healthy subjects. Conclusion From our translational study which included three animal models and two PD patient cohorts, we propose a promising composite biomarker exhibiting a high level of predictivity for PD diagnosis in its early phase, before motor symptoms appearance. Fundings ANR, DOPALCOMP, Institut National de la Santé et de la Recherche Médicale, Grenoble Alpes University." @default.
- W3204686483 created "2021-10-11" @default.
- W3204686483 creator A5000394064 @default.
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- W3204686483 date "2021-10-05" @default.
- W3204686483 modified "2023-10-18" @default.
- W3204686483 title "Early diagnosis of Parkinson’s disease: A cross-species biomarker" @default.
- W3204686483 cites W1937880349 @default.
- W3204686483 cites W1957569525 @default.
- W3204686483 cites W1965605044 @default.
- W3204686483 cites W1972991508 @default.
- W3204686483 cites W1975770944 @default.
- W3204686483 cites W1986350121 @default.
- W3204686483 cites W1986674928 @default.
- W3204686483 cites W1988236146 @default.
- W3204686483 cites W1997208805 @default.
- W3204686483 cites W2000206334 @default.
- W3204686483 cites W2005795271 @default.
- W3204686483 cites W2008560062 @default.
- W3204686483 cites W2011025189 @default.
- W3204686483 cites W2013264191 @default.
- W3204686483 cites W2015828489 @default.
- W3204686483 cites W2021602283 @default.
- W3204686483 cites W2021787243 @default.
- W3204686483 cites W2022153650 @default.
- W3204686483 cites W2023122194 @default.
- W3204686483 cites W2024748283 @default.
- W3204686483 cites W2025360676 @default.
- W3204686483 cites W2033474606 @default.
- W3204686483 cites W2038811384 @default.
- W3204686483 cites W2044047532 @default.
- W3204686483 cites W2051366884 @default.
- W3204686483 cites W2051783722 @default.
- W3204686483 cites W2056145524 @default.
- W3204686483 cites W2061729937 @default.
- W3204686483 cites W2062833196 @default.
- W3204686483 cites W2072436084 @default.
- W3204686483 cites W2079930410 @default.
- W3204686483 cites W2081576194 @default.
- W3204686483 cites W2087129770 @default.
- W3204686483 cites W2087915468 @default.
- W3204686483 cites W2092635505 @default.
- W3204686483 cites W2095527991 @default.
- W3204686483 cites W2102440831 @default.
- W3204686483 cites W2104702563 @default.
- W3204686483 cites W2111171093 @default.
- W3204686483 cites W2112455323 @default.
- W3204686483 cites W2117232426 @default.
- W3204686483 cites W2117524242 @default.
- W3204686483 cites W2118357770 @default.
- W3204686483 cites W2123882607 @default.
- W3204686483 cites W2125269329 @default.
- W3204686483 cites W2131694758 @default.
- W3204686483 cites W2140978740 @default.
- W3204686483 cites W2145954079 @default.
- W3204686483 cites W2147177009 @default.
- W3204686483 cites W2149559973 @default.
- W3204686483 cites W2156451975 @default.
- W3204686483 cites W2166496419 @default.
- W3204686483 cites W2178280384 @default.
- W3204686483 cites W2192090354 @default.
- W3204686483 cites W2202641067 @default.
- W3204686483 cites W2214531950 @default.
- W3204686483 cites W2222505591 @default.
- W3204686483 cites W2228108424 @default.
- W3204686483 cites W2295182096 @default.
- W3204686483 cites W2296450808 @default.
- W3204686483 cites W2492769849 @default.
- W3204686483 cites W2558704843 @default.
- W3204686483 cites W2560669064 @default.
- W3204686483 cites W2561489434 @default.
- W3204686483 cites W2587271278 @default.
- W3204686483 cites W2591756301 @default.
- W3204686483 cites W2738754972 @default.
- W3204686483 cites W2793894570 @default.
- W3204686483 cites W2795013773 @default.
- W3204686483 cites W2804277227 @default.
- W3204686483 cites W2806031622 @default.
- W3204686483 cites W2892711299 @default.
- W3204686483 cites W2899188579 @default.
- W3204686483 cites W2913268077 @default.
- W3204686483 cites W2916480254 @default.
- W3204686483 cites W2944986477 @default.
- W3204686483 cites W2951652068 @default.
- W3204686483 cites W2973064436 @default.
- W3204686483 cites W2996376268 @default.
- W3204686483 cites W4211151576 @default.
- W3204686483 doi "https://doi.org/10.1101/2021.10.04.462993" @default.