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• W3204687391 abstract "Abstract Purpose Neoadjuvant chemotherapy(NACT) in gastroesophageal junction(GEJ) and gastric cancer(GC) was shown to improve survival in recent studies. We aimed to share our real-life experience of patients who received NACT in order to compare the efficacy and toxicity profile of different chemotherapy regimens in our country. Methods This retrospective multicenter study included locally advanced GC and GEJ cancer patients who received NACT, and had pathological response evaluation between 2007 and 2021. Relation between CT regimens and pathological evaluation were analyzed. Results A total of 728 patients from 45 oncology centers in Turkey were included. Median age at the time of diagnosis was 60 (range: 18-68). Most frequent NACT regimens used were FLOT (65%), DCF (18%) and ECF (8.1%), respectively. In the total study group pCR rate was 8.2%, R0 resection rate 88.5%, and D2 dissection rate was 66.8%. Rate of pCR and near-CR (26.4%), and R0 resection (92.6%) were higher in FLOT arm (p= 0.005 and <0.001). Patients who received FLOT had significantly higher chemotherapy-related toxicity rate compared to patients who received other regimens (p=0.02).Median follow-up time was 17 months (range: 3-106 months). Estimated median overall survival (OS) was 59.4 months (95% CI: 32.9-86.0) and disease-free survival (DFS) was 47.6 months (95% CI: 24.4-70.8). The highest 5-year estimated OS rate was also shown in FLOT arm (58%). Conclusion In our real-life study, FLOT regimen has superior survival outcome despite worse toxicity profile. Clinicians should tailor treatment regimens according to patients’ multifactorial status and comorbidities for to obtain best outcomes." @default.
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• W3204687391 date "2021-09-27" @default.
• W3204687391 modified "2023-10-16" @default.
• W3204687391 title "Real Life Experience of Patients With Locally Advanced Gastric and Gastroesophageal Junction Adenocarcinoma Treated With Neoadjuvant Chemotherapy: a Turkish Oncology Group Study" @default.
• W3204687391 doi "https://doi.org/10.21203/rs.3.rs-884239/v1" @default.
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