Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204687645> ?p ?o ?g. }
- W3204687645 endingPage "165" @default.
- W3204687645 startingPage "158" @default.
- W3204687645 abstract "The Apolipoprotein E ε4 (APOE ε4) haplotype is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). The Translocase of Outer Mitochondrial Membrane-40 (TOMM40) gene maintains cellular bioenergetics, which is disrupted in AD. TOMM40 rs2075650 ('650) G versus A carriage is consistently related to neural and cognitive outcomes, but it is unclear if and how it interacts with APOE. We examined 21 orthogonal neural networks among 8,222 middle-aged to aged participants in the UK Biobank cohort. ANOVA and multiple linear regression tested main effects and interactions with APOE and TOMM40 '650 genotypes, and if age and sex acted as moderators. APOE ε4 was associated with less strength in multiple networks, while '650 G versus A carriage was related to more language comprehension network strength. In APOE ε4 carriers, '650 G-carriage led to less network strength with increasing age, while in non-G-carriers this was only seen in women but not men. TOMM40 may shift what happens to network activity in aging APOE ε4 carriers depending on sex." @default.
- W3204687645 created "2021-10-11" @default.
- W3204687645 creator A5017678527 @default.
- W3204687645 creator A5046225712 @default.
- W3204687645 creator A5048893803 @default.
- W3204687645 creator A5050249978 @default.
- W3204687645 creator A5052668077 @default.
- W3204687645 creator A5066238062 @default.
- W3204687645 creator A5067362049 @default.
- W3204687645 creator A5073909692 @default.
- W3204687645 creator A5082869062 @default.
- W3204687645 creator A5083257758 @default.
- W3204687645 creator A5083556401 @default.
- W3204687645 creator A5087302585 @default.
- W3204687645 creator A5087372065 @default.
- W3204687645 date "2022-01-01" @default.
- W3204687645 modified "2023-10-13" @default.
- W3204687645 title "APOE, TOMM40, and sex interactions on neural network connectivity" @default.
- W3204687645 cites W1781319707 @default.
- W3204687645 cites W1783430292 @default.
- W3204687645 cites W1928148042 @default.
- W3204687645 cites W1965085108 @default.
- W3204687645 cites W1971032414 @default.
- W3204687645 cites W1976946296 @default.
- W3204687645 cites W1983911383 @default.
- W3204687645 cites W1984737558 @default.
- W3204687645 cites W2002923643 @default.
- W3204687645 cites W2007572953 @default.
- W3204687645 cites W2013955107 @default.
- W3204687645 cites W2018880103 @default.
- W3204687645 cites W2025267739 @default.
- W3204687645 cites W2036362108 @default.
- W3204687645 cites W2039003482 @default.
- W3204687645 cites W2040281060 @default.
- W3204687645 cites W2055186021 @default.
- W3204687645 cites W2072500831 @default.
- W3204687645 cites W2074109912 @default.
- W3204687645 cites W2074829442 @default.
- W3204687645 cites W2075605386 @default.
- W3204687645 cites W2082704080 @default.
- W3204687645 cites W2083110718 @default.
- W3204687645 cites W2090271811 @default.
- W3204687645 cites W2104173495 @default.
- W3204687645 cites W2115182824 @default.
- W3204687645 cites W2126650951 @default.
- W3204687645 cites W2134858198 @default.
- W3204687645 cites W2136404471 @default.
- W3204687645 cites W2143285014 @default.
- W3204687645 cites W2150125870 @default.
- W3204687645 cites W2155063811 @default.
- W3204687645 cites W2158592797 @default.
- W3204687645 cites W2162988145 @default.
- W3204687645 cites W2170765166 @default.
- W3204687645 cites W2439833924 @default.
- W3204687645 cites W2522628945 @default.
- W3204687645 cites W2566652232 @default.
- W3204687645 cites W2573640914 @default.
- W3204687645 cites W2605664024 @default.
- W3204687645 cites W2607804943 @default.
- W3204687645 cites W2763781586 @default.
- W3204687645 cites W2770349518 @default.
- W3204687645 cites W2836582965 @default.
- W3204687645 cites W2895486342 @default.
- W3204687645 cites W2902531485 @default.
- W3204687645 cites W2911331420 @default.
- W3204687645 cites W2952574438 @default.
- W3204687645 cites W2954019805 @default.
- W3204687645 cites W2973372456 @default.
- W3204687645 cites W3005159421 @default.
- W3204687645 cites W3032005411 @default.
- W3204687645 cites W3084232510 @default.
- W3204687645 cites W3102410473 @default.
- W3204687645 cites W3111203418 @default.
- W3204687645 cites W4210821588 @default.
- W3204687645 doi "https://doi.org/10.1016/j.neurobiolaging.2021.09.020" @default.
- W3204687645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34740077" @default.
- W3204687645 hasPublicationYear "2022" @default.
- W3204687645 type Work @default.
- W3204687645 sameAs 3204687645 @default.
- W3204687645 citedByCount "7" @default.
- W3204687645 countsByYear W32046876452022 @default.
- W3204687645 countsByYear W32046876452023 @default.
- W3204687645 crossrefType "journal-article" @default.
- W3204687645 hasAuthorship W3204687645A5017678527 @default.
- W3204687645 hasAuthorship W3204687645A5046225712 @default.
- W3204687645 hasAuthorship W3204687645A5048893803 @default.
- W3204687645 hasAuthorship W3204687645A5050249978 @default.
- W3204687645 hasAuthorship W3204687645A5052668077 @default.
- W3204687645 hasAuthorship W3204687645A5066238062 @default.
- W3204687645 hasAuthorship W3204687645A5067362049 @default.
- W3204687645 hasAuthorship W3204687645A5073909692 @default.
- W3204687645 hasAuthorship W3204687645A5082869062 @default.
- W3204687645 hasAuthorship W3204687645A5083257758 @default.
- W3204687645 hasAuthorship W3204687645A5083556401 @default.
- W3204687645 hasAuthorship W3204687645A5087302585 @default.
- W3204687645 hasAuthorship W3204687645A5087372065 @default.
- W3204687645 hasBestOaLocation W32046876452 @default.
- W3204687645 hasConcept C126322002 @default.