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- W3204689056 abstract "Rupture of aortic aneurysm and dissection (AAD) remains a leading cause of death. Progressive smooth muscle cell (SMC) loss is a crucial feature of AAD that contributes to aortic dysfunction and degeneration, leading to aortic aneurysm, dissection, and, ultimately, rupture. Understanding the molecular mechanisms of SMC loss and identifying pathways that promote SMC death in AAD are critical for developing an effective pharmacologic therapy to prevent aortic destruction and disease progression. Cell death is controlled by programmed cell death pathways, including apoptosis, necroptosis, pyroptosis, and ferroptosis. Although these pathways share common stimuli and triggers, each type of programmed cell death has unique features and activation pathways. A growing body of evidence supports a critical role for programmed cell death in the pathogenesis of AAD, and inhibitors of various types of programmed cell death represent a promising therapeutic strategy. This review discusses the different types of programmed cell death pathways and their features, induction, contributions to AAD development, and therapeutic potential. We also highlight the clinical significance of programmed cell death for further studies." @default.
- W3204689056 created "2021-10-11" @default.
- W3204689056 creator A5004020956 @default.
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- W3204689056 creator A5028693685 @default.
- W3204689056 creator A5034855502 @default.
- W3204689056 creator A5047160347 @default.
- W3204689056 date "2022-02-01" @default.
- W3204689056 modified "2023-10-15" @default.
- W3204689056 title "Programmed cell death in aortic aneurysm and dissection: A potential therapeutic target" @default.
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