Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204689409> ?p ?o ?g. }
- W3204689409 endingPage "113850" @default.
- W3204689409 startingPage "113850" @default.
- W3204689409 abstract "The human tyrosinase is the most prominent therapeutic target for pigmentary skin disorders. However, the overwhelming majority efforts have been devoted to search mushroom tyrosinase inhibitors, which show poor inhibitory activity on human tyrosinase and certain side effects that cause skin damage in practical application. Herein, a series of degraders that directly targeted human tyrosinase was firstly designed and synthesized based on newly developed PROTAC technology. The best PROTAC TD9 induced human tyrosinase degradation obviously in dose and time-dependent manner, and its mechanism of inducing tyrosinase degradation has also been clearly demonstrated. Besides, encouraging results that low-toxicity PROTAC TD9 was applied to reduce zebrafish melanin synthesis have been obtained, highlighting the potential to treatment of tyrosinase-related disorders. Moreover, this work has innovatively expanded the application scope of PROTAC technology and laid a solid foundation for further development of novel drugs treating pigmentary skin disorders." @default.
- W3204689409 created "2021-10-11" @default.
- W3204689409 creator A5005017909 @default.
- W3204689409 creator A5007870500 @default.
- W3204689409 creator A5024356456 @default.
- W3204689409 creator A5037135703 @default.
- W3204689409 creator A5038560939 @default.
- W3204689409 creator A5043748613 @default.
- W3204689409 creator A5054778343 @default.
- W3204689409 creator A5055398648 @default.
- W3204689409 creator A5082769654 @default.
- W3204689409 date "2021-12-01" @default.
- W3204689409 modified "2023-10-16" @default.
- W3204689409 title "Design, synthesis and biological evaluation of tyrosinase-targeting PROTACs" @default.
- W3204689409 cites W1523735757 @default.
- W3204689409 cites W1966995323 @default.
- W3204689409 cites W1968887194 @default.
- W3204689409 cites W1975732260 @default.
- W3204689409 cites W1980752944 @default.
- W3204689409 cites W1990005278 @default.
- W3204689409 cites W1992083471 @default.
- W3204689409 cites W2015123436 @default.
- W3204689409 cites W2019751519 @default.
- W3204689409 cites W2051232917 @default.
- W3204689409 cites W2068437674 @default.
- W3204689409 cites W2077821753 @default.
- W3204689409 cites W2080426025 @default.
- W3204689409 cites W2083722030 @default.
- W3204689409 cites W2083911918 @default.
- W3204689409 cites W2085610844 @default.
- W3204689409 cites W2085929900 @default.
- W3204689409 cites W2087635974 @default.
- W3204689409 cites W2123707963 @default.
- W3204689409 cites W2133230336 @default.
- W3204689409 cites W2134643552 @default.
- W3204689409 cites W2137233414 @default.
- W3204689409 cites W2138667048 @default.
- W3204689409 cites W2140424083 @default.
- W3204689409 cites W2159954905 @default.
- W3204689409 cites W2161413435 @default.
- W3204689409 cites W2224624053 @default.
- W3204689409 cites W2531874273 @default.
- W3204689409 cites W2550850403 @default.
- W3204689409 cites W2566399670 @default.
- W3204689409 cites W2577030492 @default.
- W3204689409 cites W2589026097 @default.
- W3204689409 cites W2615057371 @default.
- W3204689409 cites W2770911117 @default.
- W3204689409 cites W2776177399 @default.
- W3204689409 cites W2786693416 @default.
- W3204689409 cites W2804238759 @default.
- W3204689409 cites W2805296794 @default.
- W3204689409 cites W2806694687 @default.
- W3204689409 cites W2883024539 @default.
- W3204689409 cites W2912114516 @default.
- W3204689409 cites W2968014120 @default.
- W3204689409 cites W2982554531 @default.
- W3204689409 cites W2982643808 @default.
- W3204689409 cites W2991640675 @default.
- W3204689409 cites W2998416999 @default.
- W3204689409 cites W3009333975 @default.
- W3204689409 cites W3015034914 @default.
- W3204689409 cites W3021988369 @default.
- W3204689409 cites W3046866315 @default.
- W3204689409 cites W3083638322 @default.
- W3204689409 cites W3093920247 @default.
- W3204689409 doi "https://doi.org/10.1016/j.ejmech.2021.113850" @default.
- W3204689409 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34628235" @default.
- W3204689409 hasPublicationYear "2021" @default.
- W3204689409 type Work @default.
- W3204689409 sameAs 3204689409 @default.
- W3204689409 citedByCount "10" @default.
- W3204689409 countsByYear W32046894092022 @default.
- W3204689409 countsByYear W32046894092023 @default.
- W3204689409 crossrefType "journal-article" @default.
- W3204689409 hasAuthorship W3204689409A5005017909 @default.
- W3204689409 hasAuthorship W3204689409A5007870500 @default.
- W3204689409 hasAuthorship W3204689409A5024356456 @default.
- W3204689409 hasAuthorship W3204689409A5037135703 @default.
- W3204689409 hasAuthorship W3204689409A5038560939 @default.
- W3204689409 hasAuthorship W3204689409A5043748613 @default.
- W3204689409 hasAuthorship W3204689409A5054778343 @default.
- W3204689409 hasAuthorship W3204689409A5055398648 @default.
- W3204689409 hasAuthorship W3204689409A5082769654 @default.
- W3204689409 hasConcept C104317684 @default.
- W3204689409 hasConcept C107538193 @default.
- W3204689409 hasConcept C181199279 @default.
- W3204689409 hasConcept C185592680 @default.
- W3204689409 hasConcept C2776878037 @default.
- W3204689409 hasConcept C55493867 @default.
- W3204689409 hasConcept C86803240 @default.
- W3204689409 hasConcept C87554066 @default.
- W3204689409 hasConcept C98274493 @default.
- W3204689409 hasConceptScore W3204689409C104317684 @default.
- W3204689409 hasConceptScore W3204689409C107538193 @default.
- W3204689409 hasConceptScore W3204689409C181199279 @default.
- W3204689409 hasConceptScore W3204689409C185592680 @default.
- W3204689409 hasConceptScore W3204689409C2776878037 @default.