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- W3204690042 endingPage "9635" @default.
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- W3204690042 abstract "Limited studies measure extensional rheology in protein solutions due to volume constraints and measurement challenges. We developed a small-volume, dripping-onto-substrate (DoS) extensional rheology device to measure the capillary thinning of protein and protein-excipient solutions via DoS for the first time. Ovalbumin (OVA) was used as a model system, examined via DoS both with and without excipient poloxamer 188 (P188). Water and dilute OVA break apart rapidly and demonstrate inertiocapillary (IC) thinning behavior, where longer breakup times in OVA can be attributed to lower surface tension. Further increasing OVA content leads to longer breakup times and deviations from IC thinning at the start of thinning, however, no evidence of elastic behavior is observed. P188 more effectively lowers the droplet surface tension than OVA, transitioning from IC behavior in dilute solution to weakly elastic behavior at higher concentrations. Combined protein/excipient formulations act synergistically at low concentrations, where breakup times are identical to those of the individual components despite the higher total concentration. However concentrated protein/excipient formulations exhibit elasticity, where extensional rheology parameters depend on P188 content and total concentration. These findings imply that excipients intended to stabilize proteins in shear flow can cause undesirable behavior in extensional flows like injection." @default.
- W3204690042 created "2021-10-11" @default.
- W3204690042 creator A5061096456 @default.
- W3204690042 creator A5065579584 @default.
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- W3204690042 date "2021-01-01" @default.
- W3204690042 modified "2023-10-17" @default.
- W3204690042 title "Small-volume extensional rheology of concentrated protein and protein-excipient solutions" @default.
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- W3204690042 doi "https://doi.org/10.1039/d1sm01253c" @default.
- W3204690042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34622265" @default.
- W3204690042 hasPublicationYear "2021" @default.
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