FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204693953> ?p ?o ?g. }

• W3204693953 abstract "Dysregulation of complement activation causes a number of diseases, including paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. These conditions can be treated with monoclonal antibodies (mAbs) that bind to the complement component C5 and prevent formation of the membrane attack complex (MAC). While MAC is involved in uncontrolled lysis of erythrocytes in these patients, it is also required for serum bactericidal activity (SBA), i.e. clearance of encapsulated bacteria. Therefore, terminal complement blockage in these patients increases the risk of invasive disease by Neisseria meningitidis more than 1000-fold compared to the general population, despite obligatory vaccination. It is assumed that alternative instead of terminal pathway inhibition reduces the risk of meningococcal disease in vaccinated individuals. To address this, we investigated the SBA with alternative pathway inhibitors. Serum was collected from adults before and after vaccination with a meningococcal serogroup A, C, W, Y capsule conjugate vaccine and tested for meningococcal killing in the presence of factor B and D, C3, C5 and MASP-2 inhibitors. B meningococci were not included in this study since the immune response against protein-based vaccines is more complex. Unsurprisingly, inhibition of C5 abrogated killing of meningococci by all sera. In contrast, both factor B and D inhibitors affected meningococcal killing in sera from individuals with low, but not with high bactericidal anti-capsular titers. While the anti-MASP-2 mAb did not impair SBA, inhibition of C3 impeded meningococcal killing in most, but not in all sera. These data provide evidence that vaccination can provide protection against invasive meningococcal disease in patients treated with alternative pathway inhibitors." @default.
• W3204693953 created "2021-10-11" @default.
• W3204693953 creator A5025421898 @default.
• W3204693953 creator A5026314935 @default.
• W3204693953 creator A5039533464 @default.
• W3204693953 creator A5041557391 @default.
• W3204693953 creator A5057439774 @default.
• W3204693953 creator A5064977458 @default.
• W3204693953 creator A5065156283 @default.
• W3204693953 creator A5072849750 @default.
• W3204693953 date "2021-10-08" @default.
• W3204693953 modified "2023-10-17" @default.
• W3204693953 title "Alternative Complement Pathway Inhibition Does Not Abrogate Meningococcal Killing by Serum of Vaccinated Individuals" @default.
• W3204693953 cites W1221126392 @default.
• W3204693953 cites W1807003203 @default.
• W3204693953 cites W1979443248 @default.
• W3204693953 cites W1980248442 @default.
• W3204693953 cites W1989011168 @default.
• W3204693953 cites W1997897807 @default.
• W3204693953 cites W2010038769 @default.
• W3204693953 cites W2019124488 @default.
• W3204693953 cites W2031215908 @default.
• W3204693953 cites W2041559281 @default.
• W3204693953 cites W2075176915 @default.
• W3204693953 cites W2084508230 @default.
• W3204693953 cites W2092326939 @default.
• W3204693953 cites W2097222143 @default.
• W3204693953 cites W2106151409 @default.
• W3204693953 cites W2115236824 @default.
• W3204693953 cites W2115350923 @default.
• W3204693953 cites W2119999990 @default.
• W3204693953 cites W2129655108 @default.
• W3204693953 cites W2130460485 @default.
• W3204693953 cites W2134778321 @default.
• W3204693953 cites W2148938842 @default.
• W3204693953 cites W2155291295 @default.
• W3204693953 cites W2162781391 @default.
• W3204693953 cites W2167803041 @default.
• W3204693953 cites W2171498887 @default.
• W3204693953 cites W2171902734 @default.
• W3204693953 cites W2195602154 @default.
• W3204693953 cites W2269583392 @default.
• W3204693953 cites W2276272428 @default.
• W3204693953 cites W2423078538 @default.
• W3204693953 cites W2434040811 @default.
• W3204693953 cites W2548090658 @default.
• W3204693953 cites W2705109811 @default.
• W3204693953 cites W2730107276 @default.
• W3204693953 cites W2775288206 @default.
• W3204693953 cites W2827929011 @default.
• W3204693953 cites W2889232296 @default.
• W3204693953 cites W2897698160 @default.
• W3204693953 cites W2909312389 @default.
• W3204693953 cites W2914487156 @default.
• W3204693953 cites W2927939151 @default.
• W3204693953 cites W2964012416 @default.
• W3204693953 cites W2965750608 @default.
• W3204693953 cites W2971051222 @default.
• W3204693953 cites W2985982704 @default.
• W3204693953 cites W3005860032 @default.
• W3204693953 cites W3042589753 @default.
• W3204693953 cites W3046126914 @default.
• W3204693953 cites W3048507351 @default.
• W3204693953 cites W3049300697 @default.
• W3204693953 cites W3084100353 @default.
• W3204693953 cites W3101364403 @default.
• W3204693953 cites W3138200627 @default.
• W3204693953 cites W3177156232 @default.
• W3204693953 cites W3195932425 @default.
• W3204693953 cites W4241342138 @default.
• W3204693953 cites W4249066710 @default.
• W3204693953 cites W867251615 @default.
• W3204693953 doi "https://doi.org/10.3389/fimmu.2021.747594" @default.
• W3204693953 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8531814" @default.
• W3204693953 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34691058" @default.
• W3204693953 hasPublicationYear "2021" @default.
• W3204693953 type Work @default.
• W3204693953 sameAs 3204693953 @default.
• W3204693953 citedByCount "12" @default.
• W3204693953 countsByYear W32046939532022 @default.
• W3204693953 countsByYear W32046939532023 @default.
• W3204693953 crossrefType "journal-article" @default.
• W3204693953 hasAuthorship W3204693953A5025421898 @default.
• W3204693953 hasAuthorship W3204693953A5026314935 @default.
• W3204693953 hasAuthorship W3204693953A5039533464 @default.
• W3204693953 hasAuthorship W3204693953A5041557391 @default.
• W3204693953 hasAuthorship W3204693953A5057439774 @default.
• W3204693953 hasAuthorship W3204693953A5064977458 @default.
• W3204693953 hasAuthorship W3204693953A5065156283 @default.
• W3204693953 hasAuthorship W3204693953A5072849750 @default.
• W3204693953 hasBestOaLocation W32046939531 @default.
• W3204693953 hasConcept C111684460 @default.
• W3204693953 hasConcept C159047783 @default.
• W3204693953 hasConcept C159654299 @default.
• W3204693953 hasConcept C182629451 @default.
• W3204693953 hasConcept C189446657 @default.
• W3204693953 hasConcept C203014093 @default.
• W3204693953 hasConcept C22070199 @default.
• W3204693953 hasConcept C2776645655 @default.
• W3204693953 hasConcept C2777346216 @default.

• next