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- W3204694139 abstract "Repetitive transcranial magnetic stimulation (rTMS) is used to alter cerebral neuroplasticity and treat various neurological disorders. However, the mechanisms of action and the effect of different stimulation parameters on the outcome, remain uncertain. To address these deficits, this thesis explored rTMS in preclinical models of depression and Alzheimer’s disease (AD) examining behavioural and biological outcomes. We showed that medium and high intensity rTMS to the frontal cortex improved behavioural deficits in the olfactory bulbectomy model of depression; however they had differing effects on the underlying neuropathology. In a genetic mouse model of AD, we investigated different excitatory or inhibitory frequencies of low intensity rTMS delivered to the hippocampus. In this model excitatory frequencies improved memory and altered synaptic morphology in hippocampal pyramidal cells. These two studies suggest that rTMS can be tailored to specific neurological conditions by altering the location, intensity and frequency of stimulation. For a disorder such as depression where changes in limbic connectivity underlie the disorder, higher intensity stimulation focused over the frontal cortex proved most effective. Whereas, in AD where maintaining synaptic connections is impaired, synaptic maintenance was improved by low intensity rTMS focused to the area of deficit." @default.
- W3204694139 created "2021-10-11" @default.
- W3204694139 creator A5066954737 @default.
- W3204694139 date "2018-11-16" @default.
- W3204694139 modified "2023-09-25" @default.
- W3204694139 title "Investigation of brain stimulation in animal models of depression and Alzheimer’s disease : feasibility of tailored treatments" @default.
- W3204694139 hasPublicationYear "2018" @default.
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