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- W3204694158 abstract "Infection with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) can result in arterial thrombosis and acute limb ischemia (ALI) with devastating consequences. We compared the outcomes of ALI in the lower extremities in patients with and without coronavirus disease 2019 (COVID-19) in the United States. Queries were created on TriNetX, a federated network of healthcare organizations across the United States that provides de-identified patient data. International Classification of Diseases, 10th revision, diagnostic codes were used to identify patients with ALI of the lower extremities and COVID-19. The study period was defined as January 20, 2020 to March 1, 2021. Statistical analyses, including propensity score matching, were performed using TriNetX's internal software. The outcomes included mortality, stroke, myocardial infarction, major adverse limb events, reintervention, and acute renal failure rates. The baseline cohort characteristics were also collected. ALI patients with COVID-19 (ALI C19+; n = 313) were significantly less likely than ALI patients without COVID-19 (ALI; n = 9300) to have baseline comorbidities, including nicotine dependence (18% vs 33%; P < .0001). The ALI C19+ patients had significantly higher 30-day rates of mortality (15.974% vs 3.774%; P < .0001), major adverse limb events (4.153% vs 1.806%; P = .0027), reintervention (4.181% vs 1.680%; P = .0015), and acute renal failure (19.808% vs 8.032%; P < .0027). After propensity matching, ALI C19+ patients still had significantly higher rates of mortality (16.026% vs 3.846%; P < .0001) and acute renal failure (19.872% vs 8.013%; P < .0001). Despite a lower prevalence of comorbidities, ALI C19+ patients had significantly higher rates of mortality, major adverse limb events, reintervention, and acute renal failure compared with the patients with ALI without COVID-19. After controlling for age, sex, ethnicity, and comorbidities, only the rates of mortality and acute renal failure were significant. This suggests that COVID-19 might be directly responsible for some of the adverse outcomes for ALI C19+ patients, and the prevalence of comorbidities before SARS-CoV-2 infection might significantly worsen their outcomes." @default.
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- W3204694158 date "2021-10-01" @default.
- W3204694158 modified "2023-10-09" @default.
- W3204694158 title "Early Outcomes of Acute Limb Ischemia in Coronavirus Disease 2019: A Multicenter, Retrospective Cohort Study" @default.
- W3204694158 doi "https://doi.org/10.1016/j.jvs.2021.07.079" @default.
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