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- W3204694510 abstract "For decades, the pathological definition of the vulnerable plaque led to invaluable insights into the mechanisms that underlie myocardial infarction and stroke. Beyond plaque rupture, other mechanisms, such as erosion, may elicit thrombotic events underlining the complexity and diversity of the atherosclerotic disease. Novel insights, based on single-cell transcriptomics and other omics methods, provide tremendous opportunities in the ongoing search for cell-specific determinants that will fine-tune the description of the thrombosis prone lesion. It coincides with an increasing awareness that knowledge on lesion characteristics, cell plasticity and clinical presentation of ischemic cardiovascular events have shifted over the past decades. This shift correlates with an observed changes of cell composition towards phenotypical stabilizing of human plaques. These stabilization features and mechanisms are directly mediated by the cells present in plaques and can be mimicked in vitro via primary plaque cells derived from human atherosclerotic tissues. In addition, the rapidly evolving of sequencing technologies identify many candidate genes and molecular mechanisms that may influence the risk of developing an atherosclerotic thrombotic event - which bring the next challenge in sharp focus: how to translate these cell-specific insights into tangible functional and translational discoveries?" @default.
- W3204694510 created "2021-10-11" @default.
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- W3204694510 date "2021-10-01" @default.
- W3204694510 modified "2023-09-23" @default.
- W3204694510 title "The changing landscape of the vulnerable plaque: a call for fine-tuning of preclinical models" @default.
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- W3204694510 cites W2039068212 @default.
- W3204694510 cites W2044406870 @default.
- W3204694510 cites W2048656545 @default.
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- W3204694510 cites W2077548365 @default.
- W3204694510 cites W2081527966 @default.
- W3204694510 cites W2092430017 @default.
- W3204694510 cites W2102161788 @default.
- W3204694510 cites W2103680698 @default.
- W3204694510 cites W2106203321 @default.
- W3204694510 cites W2109286340 @default.
- W3204694510 cites W2114092046 @default.
- W3204694510 cites W2118233199 @default.
- W3204694510 cites W2120272302 @default.
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- W3204694510 cites W2130458932 @default.
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- W3204694510 cites W2979167769 @default.
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- W3204694510 cites W3034882951 @default.
- W3204694510 cites W3042705713 @default.
- W3204694510 cites W3089136059 @default.
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- W3204694510 doi "https://doi.org/10.1016/j.vph.2021.106924" @default.
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