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- W3204702144 abstract "# PurposeSecondary endothelial keratoplasty (EK) represents an increasingly prominent indication for EK. In particular, Descemet membrane endothelial keratoplasty (DMEK) is emerging as a feasible technique in eyes with failed Descemet stripping endothelial keratoplasty (DSEK) grafts. Our aim was to analyse the anatomical and visual outcomes and safety of secondary DMEK in complex eyes with failed DSEK grafts.# MethodsThis study was a retrospective case series of complex eyes undergoing secondary DMEK for failed previous DSEK grafts. Four eyes of four patients were analysed, with a mean patient age of 61.8 ± 20.1 years. Best-corrected visual acuity (BCVA, logMAR) before DMEK ranged from 1.30 logMAR to 1.85 logMAR. We analysed the indication of primary and secondary EK, BCVA before and at the final follow-up observation after secondary DMEK (logMAR), corneal thickness, endothelial cell loss rate (%ECL) and complications.# ResultsIn eyes with functioning DMEK grafts, BCVA improved from 1.60 logMAR (range 1.30-1.60 logMAR) to 0.12 logMAR (range 0.12-0.40 logMAR) at the last postoperative observation (median follow-up time = 33 months (range 18-78 months)). The final corneal thickness in successful grafts was 520.7 ± 40.4 µm. The mean %ECL was 46.6% ± 10.1%. One eye required rebubbling for graft detachment and ended in graft failure requiring tertiary keratoplasty, and no eyes experienced allograft rejection episodes.# ConclusionSecondary DMEK is surgically feasible and provides visual improvement after a previous failed DSEK, even in complex eyes with severe comorbidities." @default.
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- W3204702144 date "2021-09-11" @default.
- W3204702144 modified "2023-10-17" @default.
- W3204702144 title "Secondary DMEK after failed DSEK graft in complex eyes – retrospective case series" @default.
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