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- W3204708194 endingPage "290" @default.
- W3204708194 startingPage "279" @default.
- W3204708194 abstract "NOTCH signaling is a highly conserved pathway mediated by four receptors (NOTCH 1-4) playing critical functions in proliferation, differentiation, and cell death. Under physiologic circumstances, NOTCH2 is a key regulator in marginal zone differentiation and development. Over the last decade, growing data demonstrated frequent NOTCH2 mutations in splenic marginal zone lymphoma (SMZL) underscoring its critical role in the pathogenesis of this disease. Moreover, NOTCH2 specificity across studies supports the rationale to assess its value as a diagnosis biomarker in a disease without pathognomonic features. These data make NOTCH signaling an appealing target for drug discovery in SMZL; however, prior efforts attempting to manipulate this pathway failed to demonstrate meaningful clinical benefit, or their safety profile prevented further development. In this review, we discuss the current knowledge of NOTCH implications in the pathogenesis and as a potential druggable target in SMZL." @default.
- W3204708194 created "2021-10-11" @default.
- W3204708194 creator A5049069261 @default.
- W3204708194 creator A5079899240 @default.
- W3204708194 date "2021-09-29" @default.
- W3204708194 modified "2023-10-17" @default.
- W3204708194 title "NOTCH signaling in the pathogenesis of splenic marginal zone lymphoma—opportunities for therapy" @default.
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