FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204735144> ?p ?o ?g. }

• W3204735144 endingPage "7974" @default.
• W3204735144 startingPage "7964" @default.
• W3204735144 abstract "Long non-coding RNAs (lncRNAs) play important regulatory roles in hepatocellular carcinoma (HCC). However, the function of LOC107985656 in HCC progression remains unclear. The lncRNA, mRNA and miRNA levels in HCC tissues or cells were measured using real-time quantitative polymerase chain reaction (RT-qPCR). The proliferation of cancer cells was evaluated using 3-(4, 5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) viability and colony formation assays. Bioinformatics prediction, dual luciferase assay and RNA pull-down assay were performed to analyze the relationships between LOC107985656 and miR-106b-5p, or miR-106b-5p and large tumor suppressor 1 (LATS1). The protein expression levels were detected using Western blot. Results showed that LncRNA LOC107985656 was downregulated in HCC tissues and cells. Upregulation of LOC107985656 inhibited the proliferation of HCC cells, whereas its knockdown promoted this phenomenon. LOC107985656 could activate the tumor-suppressive Hippo pathway by repressing yes association protein (YAP) and WW domain-containing transcription regulator protein 1 (WWTR1, also known as TAZ) (two homologs of Yki) protein expression in HCC. Further investigation suggested that LOC107985656 regulated the expression of LATS1 by acting as a sponge for absorbing miR-106b-5p in HCC cells. In conclusion, this study unraveled the role of LOC107985656 following a ceRNA (competing endogenous RNAs) mechanism for the miR-106b-5p/LATS1 axis in HCC. The results indicate potential diagnostic and therapeutic applications of LOC107985656 in HCC.Abbreviations:HCC: hepatocellular carcinoma; LncRNA: long non-coding RNA; LATS1: large tumor suppressor 1; MTT: 3-(4, 5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide; YAP: yes association protein; WWTR1: WW domain-containing transcription regulator protein 1; cDNA: single-stranded complementary DNA; RT-qPCR: real-time quantitative polymerase chain reaction; Radio-Immunoprecipitation Assay (RIPA); BCA: bicinchoninic acid; ASO: antisense oligonucleotide; MST1/2: Ste20-like kinases 1/2; TEAD: TEA domain transcription factor; ceRNA: competing endogenous RNAs." @default.
• W3204735144 created "2021-10-11" @default.
• W3204735144 creator A5018324533 @default.
• W3204735144 creator A5044772105 @default.
• W3204735144 creator A5086754965 @default.
• W3204735144 date "2021-01-01" @default.
• W3204735144 modified "2023-09-29" @default.
• W3204735144 title "Long non-coding RNA LOC107985656 represses the proliferation of hepatocellular carcinoma cells through activation of the tumor-suppressive Hippo pathway" @default.
• W3204735144 cites W1967480655 @default.
• W3204735144 cites W1995149018 @default.
• W3204735144 cites W2021181675 @default.
• W3204735144 cites W2060070915 @default.
• W3204735144 cites W2111003795 @default.
• W3204735144 cites W2132264180 @default.
• W3204735144 cites W2310964761 @default.
• W3204735144 cites W2366242921 @default.
• W3204735144 cites W2395187393 @default.
• W3204735144 cites W2606915080 @default.
• W3204735144 cites W2620140547 @default.
• W3204735144 cites W2625600561 @default.
• W3204735144 cites W2782227398 @default.
• W3204735144 cites W2790212419 @default.
• W3204735144 cites W2800944585 @default.
• W3204735144 cites W2901259002 @default.
• W3204735144 cites W2917222676 @default.
• W3204735144 cites W2945535500 @default.
• W3204735144 cites W2946065961 @default.
• W3204735144 cites W2960552578 @default.
• W3204735144 cites W2963553420 @default.
• W3204735144 cites W2972782324 @default.
• W3204735144 cites W2979907092 @default.
• W3204735144 cites W2999417355 @default.
• W3204735144 cites W3016711957 @default.
• W3204735144 cites W3121456752 @default.
• W3204735144 cites W3135267215 @default.
• W3204735144 cites W3147142721 @default.
• W3204735144 cites W3162540285 @default.
• W3204735144 cites W3169841722 @default.
• W3204735144 cites W3171861447 @default.
• W3204735144 cites W3174371922 @default.
• W3204735144 cites W3182006654 @default.
• W3204735144 cites W3190167812 @default.
• W3204735144 doi "https://doi.org/10.1080/21655979.2021.1984005" @default.
• W3204735144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34565286" @default.
• W3204735144 hasPublicationYear "2021" @default.
• W3204735144 type Work @default.
• W3204735144 sameAs 3204735144 @default.
• W3204735144 citedByCount "7" @default.
• W3204735144 countsByYear W32047351442022 @default.
• W3204735144 countsByYear W32047351442023 @default.
• W3204735144 crossrefType "journal-article" @default.
• W3204735144 hasAuthorship W3204735144A5018324533 @default.
• W3204735144 hasAuthorship W3204735144A5044772105 @default.
• W3204735144 hasAuthorship W3204735144A5086754965 @default.
• W3204735144 hasBestOaLocation W32047351441 @default.
• W3204735144 hasConcept C104317684 @default.
• W3204735144 hasConcept C105580179 @default.
• W3204735144 hasConcept C121608353 @default.
• W3204735144 hasConcept C127561419 @default.
• W3204735144 hasConcept C145059251 @default.
• W3204735144 hasConcept C153911025 @default.
• W3204735144 hasConcept C172512520 @default.
• W3204735144 hasConcept C173396325 @default.
• W3204735144 hasConcept C179185449 @default.
• W3204735144 hasConcept C185592680 @default.
• W3204735144 hasConcept C2778019345 @default.
• W3204735144 hasConcept C2780783641 @default.
• W3204735144 hasConcept C502942594 @default.
• W3204735144 hasConcept C54355233 @default.
• W3204735144 hasConcept C55493867 @default.
• W3204735144 hasConcept C60365752 @default.
• W3204735144 hasConcept C62112901 @default.
• W3204735144 hasConcept C62203573 @default.
• W3204735144 hasConcept C62478195 @default.
• W3204735144 hasConcept C67705224 @default.
• W3204735144 hasConcept C81885089 @default.
• W3204735144 hasConcept C86803240 @default.
• W3204735144 hasConcept C95444343 @default.
• W3204735144 hasConceptScore W3204735144C104317684 @default.
• W3204735144 hasConceptScore W3204735144C105580179 @default.
• W3204735144 hasConceptScore W3204735144C121608353 @default.
• W3204735144 hasConceptScore W3204735144C127561419 @default.
• W3204735144 hasConceptScore W3204735144C145059251 @default.
• W3204735144 hasConceptScore W3204735144C153911025 @default.
• W3204735144 hasConceptScore W3204735144C172512520 @default.
• W3204735144 hasConceptScore W3204735144C173396325 @default.
• W3204735144 hasConceptScore W3204735144C179185449 @default.
• W3204735144 hasConceptScore W3204735144C185592680 @default.
• W3204735144 hasConceptScore W3204735144C2778019345 @default.
• W3204735144 hasConceptScore W3204735144C2780783641 @default.
• W3204735144 hasConceptScore W3204735144C502942594 @default.
• W3204735144 hasConceptScore W3204735144C54355233 @default.
• W3204735144 hasConceptScore W3204735144C55493867 @default.
• W3204735144 hasConceptScore W3204735144C60365752 @default.
• W3204735144 hasConceptScore W3204735144C62112901 @default.
• W3204735144 hasConceptScore W3204735144C62203573 @default.
• W3204735144 hasConceptScore W3204735144C62478195 @default.
• W3204735144 hasConceptScore W3204735144C67705224 @default.

• next