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- W3204751963 endingPage "824" @default.
- W3204751963 startingPage "811" @default.
- W3204751963 abstract "The Polycomb repressive system plays a fundamental role in controlling gene expression during mammalian development. To achieve this, Polycomb repressive complexes 1 and 2 (PRC1 and PRC2) bind target genes and use histone modification-dependent feedback mechanisms to form Polycomb chromatin domains and repress transcription. The inter-relatedness of PRC1 and PRC2 activity at these sites has made it difficult to discover the specific components of Polycomb chromatin domains that drive gene repression and to understand mechanistically how this is achieved. Here, by exploiting rapid degron-based approaches and time-resolved genomics, we kinetically dissect Polycomb-mediated repression and discover that PRC1 functions independently of PRC2 to counteract RNA polymerase II binding and transcription initiation. Using single-cell gene expression analysis, we reveal that PRC1 acts uniformly within the cell population and that repression is achieved by controlling transcriptional burst frequency. These important new discoveries provide a mechanistic and conceptual framework for Polycomb-dependent transcriptional control." @default.
- W3204751963 created "2021-10-11" @default.
- W3204751963 creator A5038636863 @default.
- W3204751963 creator A5073071237 @default.
- W3204751963 creator A5076136267 @default.
- W3204751963 date "2021-10-01" @default.
- W3204751963 modified "2023-10-14" @default.
- W3204751963 title "PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency" @default.
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