FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204753780> ?p ?o ?g. }

• W3204753780 endingPage "228" @default.
• W3204753780 startingPage "227" @default.
• W3204753780 abstract "Predicting portal thrombosis in cirrhosis: A prospective study of clinical, ultrasonographic and hemostatic factorsJournal of HepatologyVol. 75Issue 6PreviewPortal vein thrombosis (PVT) is a relatively frequent event in patients with cirrhosis. While different risk factors for PVT have been reported, such as decreased portal blood flow velocity (PBFV) and parameters related with severity of portal hypertension, these are based on retrospective studies assessing only a discrete number of parameters. The aim of the current study was to evaluate the incidence and risks factors for non-tumoral PVT development in a large prospective cohort of patients with cirrhosis. Full-Text PDF Open AccessMinor role of hemostatic alternation in portal vein thrombosis pathogenesis revealed by global measurementJournal of HepatologyVol. 76Issue 1PreviewWe read with great interest the article by Turon et al. recently published in Journal of Hepatology.1 The authors comprehensively evaluated the risk factors for portal vein thrombosis (PVT) in patients with cirrhosis, including clinical and ultrasonographic parameters, hemostatic alterations and inflammatory markers. Data indicated that only those factors related to the severity of portal hypertension were associated with PVT development. Full-Text PDF Predicting portal thrombosis in cirrhosis: Some issuesJournal of HepatologyVol. 76Issue 1PreviewWe read with great interest the excellent manuscript based on a prospective study recently published by Turon F et al.1 In the 369 patients with cirrhosis without portal vein thrombosis (PVT), 29 patients developed non-tumoral PVT with reported incidences of 1.6%, 6.0% and 8.4% at 1, 3 and 5 years, respectively. In evaluating the incidence and risk factors for PVT development, the authors have concluded that platelet count, decreased portal blood flow velocity (PBFV) (<15 cm/sec) and history of variceal bleeding, rather than acquired or inherited hemostatic disorders and inflammatory status, were factors independently associated with a high PVT risk. Full-Text PDF We thank Li et al.[1]Li B. He Q. Lu G. Hong C. Chen J. Minor role of hemostatic alternation in portal vein thrombosis pathogenesis revealed by global measurement.J Hepatol. 2022; 76: 225-227Abstract Full Text Full Text PDF Scopus (1) Google Scholar and Dai et al.[2]Dai C.-Y. Chuang W.-L. Yu M.-L. Predicting portal thrombosis in cirrhosis: some issues.J Hepatol. 2022; 76: 224-225Abstract Full Text Full Text PDF Scopus (1) Google Scholar for their interest in our recent publication in the Journal of Hepatology.[3]Turon F. Driever E.G. Baiges A. Cerda E. García-Criado Á. Gilabert R. et al.Predicting portal thrombosis in cirrhosis: a prospective study of clinical, ultrasonographic and hemostatic factors.J Hepatol. 2021; 75: 1367-1376Abstract Full Text Full Text PDF Scopus (50) Google Scholar Li et al. reported the results of a thromboelastography assay in 58 patients with cirrhosis undergoing transjugular intrahepatic portosystemic shunt, 12 of whom had portal vein thrombosis (PVT). No differences in thromboelastography were found between the 12 patients with PVT and the 46 without. Despite this being a different scenario from ours, their results reinforced our finding that hemostatic alterations are not the main risk factors for PVT. In addition, the authors report decreased platelet responses and propose that antiplatelet therapy would likely be ineffective in prevention or treatment of PVT. It has to be noted, however, that platelet function tests in thrombocytopenic blood likely underestimate true platelet reactivity, and that normal to enhanced platelet responses in patients with cirrhosis have been reported using different methodology.[4]Caldwell S. Lisman T. The cirrhotic platelet: shedding light on an enigma.Hepatology. 2017; 65: 407-410Crossref PubMed Scopus (16) Google Scholar We agree that mechanisms underlying PVT development require further exploration. Of note, we have recently demonstrated that the portal vein thrombus frequently does not consist of typical thrombus components such as platelets and fibrin. Rather, we showed the thrombus to consist, at least partly, of collagenous thickening of the portal vein intima. These results also suggest that the role of coagulation activation in PVT is more minor than previously thought.[5]Driever E.G. von Meijenfeldt F.A. Adelmeijer J. de Haas R.J. van den Heuvel M.C. Nagasami C. et al.Non-malignant portal vein thrombi in patients with cirrhosis consist of intimal fibrosis with or without a fibrin-rich thrombus.Hepatology. 2021; https://doi.org/10.1002/hep.32169Crossref Scopus (21) Google Scholar Dai et al. highlighted the relevance of plasma levels of Factor X as an independent significant factor for PVT. However, we would like to point out that the higher risk of PVT was in patients with lower levels of pro-coagulant Factor X, suggesting that this is a further sign of severity of liver disfunction more than a reflection of increased hypercoagulability. That is why we did not consider it appropriate to further explore Factor X in stratified groups as they suggested. Additionally, patients undergoing surgical procedures, such as splenectomy or devascularization for the treatment of portal hypertension were excluded from our study because these are extremely rare procedures in the setting of cirrhosis in western countries; these special sub-populations fall beyond the objective our study. The occurrence of PVT in these surgical settings is also frequently acute, whereas the development of ‘non-provoked’ PVT is usually more chronic. The pathogenesis of surgery-associated PVT in patients with cirrhosis may therefore be different from that of non-provoked PVT. The role of anticoagulant therapy in prevention of surgery-associated PVT remains to be established. Importantly, it has been demonstrated that surgery-associated PVT in patients without cirrhosis is efficiently reduced by anticoagulant therapy.[6]Yamashita Y.I. Bekki Y. Imai D. Ikegami T. Yoshizumi T. Ikeda T. et al.Efficacy of postoperative anticoagulation therapy with enoxaparin for portal vein thrombosis after hepatic resection in patients with liver cancer.Thromb Res. 2014; 134: 826-831Abstract Full Text Full Text PDF PubMed Scopus (32) Google Scholar The authors received no financial support to produce this manuscript. All authors drafted and approved the final manuscript. JCGP is a consultant for GORE and research grants from NOVARTIS. Please refer to the accompanying ICMJE disclosure forms for further details. The following is the supplementary data to this article: Download .pdf (.17 MB) Help with pdf files Multimedia component 1" @default.
• W3204753780 created "2021-10-11" @default.
• W3204753780 creator A5048400223 @default.
• W3204753780 creator A5072599627 @default.
• W3204753780 creator A5074302578 @default.
• W3204753780 date "2022-01-01" @default.
• W3204753780 modified "2023-10-06" @default.
• W3204753780 title "Reply to: Correspondence on “Predicting portal thrombosis in cirrosis: A prospective study of clinical, ultrasonographic and hemostatic factors”" @default.
• W3204753780 cites W2049078086 @default.
• W3204753780 cites W2554571643 @default.
• W3204753780 cites W3183672024 @default.
• W3204753780 cites W3197386728 @default.
• W3204753780 cites W3200281329 @default.
• W3204753780 cites W3201551928 @default.
• W3204753780 doi "https://doi.org/10.1016/j.jhep.2021.09.015" @default.
• W3204753780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34597749" @default.
• W3204753780 hasPublicationYear "2022" @default.
• W3204753780 type Work @default.
• W3204753780 sameAs 3204753780 @default.
• W3204753780 citedByCount "0" @default.
• W3204753780 crossrefType "journal-article" @default.
• W3204753780 hasAuthorship W3204753780A5048400223 @default.
• W3204753780 hasAuthorship W3204753780A5072599627 @default.
• W3204753780 hasAuthorship W3204753780A5074302578 @default.
• W3204753780 hasBestOaLocation W32047537801 @default.
• W3204753780 hasConcept C120665830 @default.
• W3204753780 hasConcept C121332964 @default.
• W3204753780 hasConcept C126322002 @default.
• W3204753780 hasConcept C126838900 @default.
• W3204753780 hasConcept C188816634 @default.
• W3204753780 hasConcept C2777214474 @default.
• W3204753780 hasConcept C2778800853 @default.
• W3204753780 hasConcept C2778808290 @default.
• W3204753780 hasConcept C2780868729 @default.
• W3204753780 hasConcept C41260117 @default.
• W3204753780 hasConcept C56900294 @default.
• W3204753780 hasConcept C61511704 @default.
• W3204753780 hasConcept C71924100 @default.
• W3204753780 hasConcept C90924648 @default.
• W3204753780 hasConceptScore W3204753780C120665830 @default.
• W3204753780 hasConceptScore W3204753780C121332964 @default.
• W3204753780 hasConceptScore W3204753780C126322002 @default.
• W3204753780 hasConceptScore W3204753780C126838900 @default.
• W3204753780 hasConceptScore W3204753780C188816634 @default.
• W3204753780 hasConceptScore W3204753780C2777214474 @default.
• W3204753780 hasConceptScore W3204753780C2778800853 @default.
• W3204753780 hasConceptScore W3204753780C2778808290 @default.
• W3204753780 hasConceptScore W3204753780C2780868729 @default.
• W3204753780 hasConceptScore W3204753780C41260117 @default.
• W3204753780 hasConceptScore W3204753780C56900294 @default.
• W3204753780 hasConceptScore W3204753780C61511704 @default.
• W3204753780 hasConceptScore W3204753780C71924100 @default.
• W3204753780 hasConceptScore W3204753780C90924648 @default.
• W3204753780 hasFunder F4320307778 @default.
• W3204753780 hasIssue "1" @default.
• W3204753780 hasLocation W32047537801 @default.
• W3204753780 hasLocation W32047537802 @default.
• W3204753780 hasLocation W32047537803 @default.
• W3204753780 hasLocation W32047537804 @default.
• W3204753780 hasOpenAccess W3204753780 @default.
• W3204753780 hasPrimaryLocation W32047537801 @default.
• W3204753780 hasRelatedWork W1994310571 @default.
• W3204753780 hasRelatedWork W2021368482 @default.
• W3204753780 hasRelatedWork W2041144771 @default.
• W3204753780 hasRelatedWork W2087451492 @default.
• W3204753780 hasRelatedWork W2122644956 @default.
• W3204753780 hasRelatedWork W2135139975 @default.
• W3204753780 hasRelatedWork W2347486323 @default.
• W3204753780 hasRelatedWork W3030235046 @default.
• W3204753780 hasRelatedWork W4231683837 @default.
• W3204753780 hasRelatedWork W4249146795 @default.
• W3204753780 hasVolume "76" @default.
• W3204753780 isParatext "false" @default.
• W3204753780 isRetracted "false" @default.
• W3204753780 magId "3204753780" @default.
• W3204753780 workType "article" @default.