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- W3204754750 abstract "Abstract Determining the forces that shape diversity in host-associated bacterial communities is critical to understanding the evolution and maintenance of metaorganisms. To gain deeper understanding of the role of host genetics in shaping gut microbial traits, we employed a powerful genetic mapping approach using inbred lines derived from the hybrid zone of two incipient house mouse species. Further, we uniquely performed our analysis on microbial traits measured at the gut mucosal interface, which is in more direct contact with host cells and the immune system. A high number of mucosa-associated bacterial taxa have significant heritability estimates; heritabilities are greater for 16S rRNA transcript-compared to gene copy-based traits, and interestingly, are positively correlated with cospeciation rate estimates. Genomewide association mapping identifies 443 loci influencing 123 taxa, with narrow genomic intervals pinpointing promising candidate genes and pathways. Importantly, we identified an enrichment of candidate genes associated with several human diseases, including inflammatory bowel disease, and functional categories including innate immunity and G-protein-coupled receptors. These results highlight key features of the genetic architecture of mammalian host-microbe interactions and how they diverge as new species form." @default.
- W3204754750 created "2021-10-11" @default.
- W3204754750 creator A5001261668 @default.
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- W3204754750 date "2021-09-28" @default.
- W3204754750 modified "2023-10-06" @default.
- W3204754750 title "Key features of the genetic architecture and evolution of host-microbe interactions revealed by high-resolution genetic mapping of the mucosa-associated gut microbiome in hybrid mice" @default.
- W3204754750 cites W1487723577 @default.
- W3204754750 cites W1625842445 @default.
- W3204754750 cites W1731374897 @default.
- W3204754750 cites W1816362081 @default.
- W3204754750 cites W1905645331 @default.
- W3204754750 cites W1965027165 @default.
- W3204754750 cites W1967453563 @default.
- W3204754750 cites W1975102735 @default.
- W3204754750 cites W1975202380 @default.
- W3204754750 cites W1977328678 @default.
- W3204754750 cites W1980168725 @default.
- W3204754750 cites W1985662139 @default.
- W3204754750 cites W2001648811 @default.
- W3204754750 cites W2012490955 @default.
- W3204754750 cites W2013358186 @default.
- W3204754750 cites W2021208119 @default.
- W3204754750 cites W2024330772 @default.
- W3204754750 cites W2030714357 @default.
- W3204754750 cites W2035618305 @default.
- W3204754750 cites W2038217946 @default.
- W3204754750 cites W2039337032 @default.
- W3204754750 cites W2041199473 @default.
- W3204754750 cites W2045949302 @default.
- W3204754750 cites W2049317326 @default.
- W3204754750 cites W2056279562 @default.
- W3204754750 cites W2058529034 @default.
- W3204754750 cites W2060485250 @default.
- W3204754750 cites W2062809207 @default.
- W3204754750 cites W2064063991 @default.
- W3204754750 cites W2071841602 @default.
- W3204754750 cites W2073332363 @default.
- W3204754750 cites W2074177270 @default.
- W3204754750 cites W2075522667 @default.
- W3204754750 cites W2081019639 @default.
- W3204754750 cites W2085284704 @default.
- W3204754750 cites W2086288240 @default.
- W3204754750 cites W2092484115 @default.
- W3204754750 cites W2095900004 @default.
- W3204754750 cites W2098619944 @default.
- W3204754750 cites W2099085143 @default.
- W3204754750 cites W2100894521 @default.
- W3204754750 cites W2104890139 @default.
- W3204754750 cites W2107199606 @default.
- W3204754750 cites W2107755054 @default.
- W3204754750 cites W2112577424 @default.
- W3204754750 cites W2113842526 @default.
- W3204754750 cites W2115947337 @default.
- W3204754750 cites W2121187468 @default.
- W3204754750 cites W2122553823 @default.
- W3204754750 cites W2123914286 @default.
- W3204754750 cites W2124673802 @default.
- W3204754750 cites W2125784987 @default.
- W3204754750 cites W2126370509 @default.
- W3204754750 cites W2128173694 @default.
- W3204754750 cites W2129917444 @default.
- W3204754750 cites W2135537964 @default.
- W3204754750 cites W2136850043 @default.
- W3204754750 cites W2136939537 @default.
- W3204754750 cites W2139129413 @default.
- W3204754750 cites W2140233939 @default.
- W3204754750 cites W2142379521 @default.
- W3204754750 cites W2147244516 @default.
- W3204754750 cites W2147697802 @default.
- W3204754750 cites W2149573313 @default.
- W3204754750 cites W2151350595 @default.
- W3204754750 cites W2161332823 @default.
- W3204754750 cites W2162088497 @default.
- W3204754750 cites W2162612026 @default.
- W3204754750 cites W2163120110 @default.
- W3204754750 cites W2178895998 @default.
- W3204754750 cites W2191298871 @default.
- W3204754750 cites W2195959072 @default.
- W3204754750 cites W2213391733 @default.
- W3204754750 cites W2297247152 @default.
- W3204754750 cites W2301371409 @default.
- W3204754750 cites W2305971353 @default.
- W3204754750 cites W2360231252 @default.
- W3204754750 cites W2401404581 @default.
- W3204754750 cites W2504233374 @default.
- W3204754750 cites W2528524934 @default.
- W3204754750 cites W2529032957 @default.
- W3204754750 cites W2531570974 @default.
- W3204754750 cites W2545964391 @default.
- W3204754750 cites W2553365624 @default.
- W3204754750 cites W2558504599 @default.
- W3204754750 cites W2559454592 @default.