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- W3204756907 endingPage "3458" @default.
- W3204756907 startingPage "3458" @default.
- W3204756907 abstract "There is an ongoing need for new therapeutic modalities against SARS-CoV-2 infection. Mast cell histamine has been implicated in the pathophysiology of COVID-19 as a regulator of proinflammatory, fibrotic, and thrombogenic processes. Consequently, mast cell histamine and its receptors represent promising pharmacological targets. At the same time, nutritional modulation of immune system function has been proposed and is being investigated for the prevention of COVID-19 or as an adjunctive strategy combined with conventional therapy. Several studies indicate that several immunonutrients can regulate mast cell activity to reduce the de novo synthesis and/or release of histamine and other mediators that are considered to mediate, at least in part, the complex pathophysiology present in COVID-19. This review summarizes the effects on mast cell histamine of common immunonutrients that have been investigated for use in COVID-19." @default.
- W3204756907 created "2021-10-11" @default.
- W3204756907 creator A5036954180 @default.
- W3204756907 creator A5043196208 @default.
- W3204756907 creator A5087427573 @default.
- W3204756907 date "2021-09-29" @default.
- W3204756907 modified "2023-10-01" @default.
- W3204756907 title "The Complex Interplay between Immunonutrition, Mast Cells, and Histamine Signaling in COVID-19" @default.
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