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- W3204757481 abstract "Abstract Background Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) is believed to play an important role in the development of acne vulgaris. Aim of the Work To investigate the presence of GM‐CSF 3928C/T and GM‐CSF 3606 T/C promoter gene polymorphisms in Egyptian acne patients. Methods To examine whether GM‐CSF single nucleotide polymorphisms (SNPs) are associated with susceptibility to acne vulgaris (AV), we investigated the genotype and allele frequencies of the SNP 3928C/T and 3606T⁄C of the GM‐CSF gene in 100 Egyptian acne patients (29 with mild acne, 38 with moderate acne, and 33 with severe acne) and 100 controls, using a PCR restriction fragment length polymorphism (RFLP) method. Results There was a highly significant difference in genotype and allele frequencies of the 3928C/T group between patients with acne vulgaris and controls for the SNP site. Regarding the 3606 T/C subgroup only a marginal significant difference was found between cases and controls in TC pattern ( p = 0.039); with the TC genotype appearing more in cases (53% of patients) than controls (35% of healthy controls). Conclusion We report a novel GM‐CSF 3928C/T promoter gene polymorphism contributing to the pathogenesis of acne in Egyptian population." @default.
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- W3204757481 date "2021-10-03" @default.
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- W3204757481 title "Association of a novel Granulocyte‐Macrophage Colony‐Stimulating Factor (GM‐CSF)‐3928C/T and GM‐CSF(3606T⁄C) Promoter gene polymorphisms with the pathogenesis and severity of acne vulgaris: A case‐controlled study" @default.
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- W3204757481 doi "https://doi.org/10.1111/jocd.14481" @default.
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